当前位置： SCI文献检索 > DIABETES CARE期刊下所有文献 > Receiver operating characteristic analysis of HLA, CTLA4, and insulin genotypes for type 1 diabetes.

Receiver operating characteristic analysis of HLA, CTLA4, and insulin genotypes for type 1 diabetes.

Abstract：

OBJECTIVE:This study assessed the ability to distinguish between type 1 diabetes-affected individuals and their unaffected relatives using HLA and single nucleotide polymorphism (SNP) genotypes. RESEARCH DESIGN AND METHODS:Eight models, ranging from only the high-risk DR3/DR4 genotype to all significantly associated HLA genotypes and two SNPs mapping to the cytotoxic T-cell-associated antigen-4 gene (CTLA4) and insulin (INS) genes, were fitted to high-resolution class I and class II HLA genotyping data for patients from the Type 1 Diabetes Genetics Consortium collection. Pairs of affected individuals and their unaffected siblings were divided into a "discovery" (n = 1,015 pairs) and a "validation" set (n = 318 pairs). The discriminating performance of various combinations of genetic information was estimated using receiver operating characteristic (ROC) curve analysis. RESULTS:The use of only the presence or absence of the high-risk DR3/DR4 genotype achieved very modest discriminating ability, yielding an area under the curve (AUC) of 0.62 in the discovery set and 0.59 in the validation set. The full model-which included HLA information from the class II loci DPB1, DRB1, and DQB1; selected alleles from HLA class I loci A and B; and SNPs from the CTLA4 and INS genes-increased the AUC to 0.74 in the discovery set and to 0.71 in the validation set. A cost-effective alternative is proposed, using genotype information equivalent to typing four SNPs (DR3, DR4-DQB1*03:02, CTLA-4, and INS), which achieved an AUC of 0.72 in the discovery set and 0.69 in the validation set. CONCLUSIONS:Genotyping data sufficient to tag DR3, DR4-DQB1*03:02, CTLA4, and INS were shown to distinguish between subjects with type 1 diabetes and their unaffected siblings adequately to achieve clinically utility to identify children in multiplex families to be considered for early intervention.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Valdes AM,Varney MD,Erlich HA,Noble JA

doi

10.2337/dc12-2284

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2504-7

issue

eissn

0149-5992

issn

1935-5548

pii

dc12-2284

journal_volume

pub_type

杂志文章,随机对照试验

在线工具

Receiver operating characteristic analysis of HLA, CTLA4, and insulin genotypes for type 1 diabetes.