Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan.


OBJECTIVE:No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study's aim was to assess this issue in Taiwan. RESEARCH DESIGN AND METHODS:A population-based cohort study was performed to analyze the database of Taiwan's National Health Insurance Program. There were 27,869 subjects aged 20-84 years with newly diagnosed diabetes from 2000 to 2012 as the group with diabetes. The group without diabetes included 111,476 sex- and age-matched subjects without diabetes. The incidence of avascular necrosis of the femoral head at the end of 2013 was measured. A multivariable Cox proportional hazards regression model was used to measure the hazard ratio (HR) and 95% CI for avascular necrosis of the femoral head associated with diabetes. RESULTS:The overall incidence of avascular necrosis of the femoral head was 1.37-fold higher in the group with diabetes than in the group without diabetes (6.53 vs. 4.76 per 1,000 person-years [95% CI 1.31-1.43]). After adjusting for confounders, the HR of avascular necrosis of the femoral head was 1.16 (95% CI 1.11-1.21) for the subjects with diabetes compared with the subjects without diabetes. CONCLUSIONS:Patients with diabetes have a 1.16-fold increased risk for developing avascular necrosis of the femoral head.


Diabetes Care


Diabetes care


Lai SW,Lin CL,Liao KF




Has Abstract


2019-01-01 00:00:00














  • Comparison of body size measurements as predictors of NIDDM in Pima Indians.

    abstract::OBJECTIVE--To determine and compare the abilities of various anthropometric measurements to predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indian men and women. RESEARCH DESIGN AND METHODS--A total of 290 male and 443 female Pima Indians were followed for up to 6 years for the devel...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Warne DK,Charles MA,Hanson RL,Jacobsson LT,McCance DR,Knowler WC,Pettitt DJ

    更新日期:1995-04-01 00:00:00

  • Secular trends in treatment and control of type 2 diabetes in an American Indian population: a 30-year longitudinal study.

    abstract:OBJECTIVE:Treatment guidelines for diabetes have become increasingly stringent as most research shows that more aggressive intervention reduces the risks for complications. Community data on the effect of these interventions are lacking. RESEARCH DESIGN AND METHODS:Changes in the pharmacologic treatment of diabetes, b...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Looker HC,Krakoff J,Andre V,Kobus K,Nelson RG,Knowler WC,Hanson RL

    更新日期:2010-11-01 00:00:00

  • Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

    abstract:OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Triplitt C,Glass L,Miyazaki Y,Wajcberg E,Gastaldelli A,De Filippis E,Cersosimo E,DeFronzo RA

    更新日期:2006-11-01 00:00:00

  • Ethnic and racial differences in diabetes care: The Insulin Resistance Atherosclerosis Study.

    abstract:OBJECTIVE:Diabetes and its complications disproportionately affect African Americans and Hispanics. Complications could be prevented with appropriate medical care. We compared five processes of care and three outcomes of care among African Americans, Hispanics, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We u...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Bonds DE,Zaccaro DJ,Karter AJ,Selby JV,Saad M,Goff DC Jr

    更新日期:2003-04-01 00:00:00

  • Management of dyslipidemia in NIDDM.

    abstract::Coronary heart disease is the leading cause of death among patients with non-insulin-dependent diabetes mellitus (NIDDM). NIDDM patients have a high frequency of dyslipidemia, which along with obesity, hypertension, and hyperglycemia may contribute significantly to accelerated coronary atherosclerosis. Because risk fa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Garg A,Grundy SM

    更新日期:1990-02-01 00:00:00

  • Effect of High-Deductible Insurance on High-Acuity Outcomes in Diabetes: A Natural Experiment for Translation in Diabetes (NEXT-D) Study.

    abstract:OBJECTIVE:High-deductible health plans (HDHPs) are now the predominant commercial health insurance benefit in the U.S. We sought to determine the effects of HDHPs on emergency department and hospital care, adverse outcomes, and total health care expenditures among patients with diabetes. RESEARCH DESIGN AND METHODS:We...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Wharam JF,Zhang F,Eggleston EM,Lu CY,Soumerai SB,Ross-Degnan D

    更新日期:2018-05-01 00:00:00

  • Insulin gene mutations as cause of diabetes in children negative for five type 1 diabetes autoantibodies.

    abstract:OBJECTIVE:Heterozygous, gain-of-function mutations of the insulin gene can cause permanent diabetes with onset ranging from the neonatal period through adulthood. The aim of our study was to screen for the insulin gene in patients who had been clinically classified as type 1 diabetic but who tested negative for type 1 ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bonfanti R,Colombo C,Nocerino V,Massa O,Lampasona V,Iafusco D,Viscardi M,Chiumello G,Meschi F,Barbetti F

    更新日期:2009-01-01 00:00:00

  • Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes.

    abstract:OBJECTIVE:It is believed that disruption of vulnerable atherosclerotic plaque and subsequent thrombus formation play critical roles in the pathogenesis of cerebral infarction. We simultaneously determined four relatively common genetic variants related to plaque rupture or subsequent local thrombus formation and evalua...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Katakami N,Takahara M,Kaneto H,Shimizu I,Ohno K,Ishibashi F,Osonoi T,Kashiwagi A,Kawamori R,Shimomura I,Matsuhisa M,Yamasaki Y

    更新日期:2010-02-01 00:00:00

  • Moderate intake of n-3 fatty acids for 2 months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Results of a controlled study.

    abstract:OBJECTIVE:To evaluate the effect of a moderate dose of fish oil on glycemic control and in vivo insulin action in type 2 diabetic men with elevated plasma triacylglycerols and to determine the effect of the same treatment on gene expression of GLUT4, lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in the a...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Luo J,Rizkalla SW,Vidal H,Oppert JM,Colas C,Boussairi A,Guerre-Millo M,Chapuis AS,Chevalier A,Durand G,Slama G

    更新日期:1998-05-01 00:00:00

  • Implementing a state-based cardiovascular disease and diabetes prevention program.

    abstract:OBJECTIVE:To evaluate weight loss and cardiometabolic risk reduction achieved through an adapted Diabetes Prevention Program intervention among adults at high risk for cardiovascular disease (CVD) and diabetes. RESEARCH DESIGN AND METHODS:Eight health care facilities implemented a group-based lifestyle intervention be...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Vanderwood KK,Hall TO,Harwell TS,Butcher MK,Helgerson SD,Montana Cardiovascular Disease and Diabetes Prevention Program Workgroup.

    更新日期:2010-12-01 00:00:00

  • Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.

    abstract:OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Beulens JW,van der A DL,Grobbee DE,Sluijs I,Spijkerman AM,van der Schouw YT

    更新日期:2010-08-01 00:00:00

  • Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study.

    abstract:OBJECTIVE:Inflammatory activity is increased in type 1 diabetes and may predispose to vascular disease. Its origin is not clear. We therefore investigated determinants of inflammation in type 1 diabetes. RESEARCH DESIGN AND METHODS:We performed a nested case-control study from the EURODIAB Prospective Complications St...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Schram MT,Chaturvedi N,Schalkwijk C,Giorgino F,Ebeling P,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study.

    更新日期:2003-07-01 00:00:00

  • Effect of rosiglitazone versus insulin on the pancreatic beta-cell function of subjects with type 2 diabetes.

    abstract:OBJECTIVE:In a previous study, we found observational evidence of improvement in beta-cell function when rosiglitazone was added to a failing oral antihyperglycemic regimen consisting of sulfonylureas and metformin. To confirm our previous observations, we designed and performed a prospective, randomized, and controlle...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ovalle F,Bell DS

    更新日期:2004-11-01 00:00:00

  • Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study.

    abstract:OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

    更新日期:2011-03-01 00:00:00

  • Asymptomatic bacteriuria and hemoglobin A1.

    abstract::We measured hemoglobin A1 (HbA1) and performed clean-catch urine cultures in 752 patients (411 men and 341 women) with non-insulin-dependent diabetes mellitus (NIDDM) attending an outpatient diabetes clinic. Prevalence of bacteriuria was significantly greater in diabetic women than in controls (9.1 vs. 5.0%, P less th...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schmitt JK,Fawcett CJ,Gullickson G

    更新日期:1986-09-01 00:00:00

  • Effect of treatment of gestational diabetes mellitus on obesity in the next generation.

    abstract:OBJECTIVE:Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS:Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mil...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Gillman MW,Oakey H,Baghurst PA,Volkmer RE,Robinson JS,Crowther CA

    更新日期:2010-05-01 00:00:00

  • Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro.

    abstract:OBJECTIVE:GLP-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs. thrice-daily prandial insulin lispro as an add-on to titrated once-daily insulin glargine. RESEARCH D...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rosenstock J,Fonseca VA,Gross JL,Ratner RE,Ahrén B,Chow FC,Yang F,Miller D,Johnson SL,Stewart MW,Leiter LA,Harmony 6 Study Group.

    更新日期:2014-08-01 00:00:00

  • Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians.

    abstract::There was a need to design a questionnaire that could accurately assess the activity patterns of Native Americans to evaluate the relationship between physical activity and diabetes. Such a questionnaire was developed and implemented into the data collection scheme of the prospective Pima Indian Study of Arizona. The ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kriska AM,Knowler WC,LaPorte RE,Drash AL,Wing RR,Blair SN,Bennett PH,Kuller LH

    更新日期:1990-04-01 00:00:00

  • Measuring diabetes self-care: a psychometric analysis of the Self-Care Inventory-Revised with adults.

    abstract:OBJECTIVE:To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS:We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometr...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Weinger K,Butler HA,Welch GW,La Greca AM

    更新日期:2005-06-01 00:00:00

  • Impaired mitochondrial function and insulin resistance of skeletal muscle in mitochondrial diabetes.

    abstract:OBJECTIVE:Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion. RESEARCH DESIGN AND METHODS:We assessed muscular mitochondrial function and li...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Szendroedi J,Schmid AI,Meyerspeer M,Cervin C,Kacerovsky M,Smekal G,Gräser-Lang S,Groop L,Roden M

    更新日期:2009-04-01 00:00:00

  • Endothelial progenitor cells are related to glycemic control in children with type 1 diabetes over time.

    abstract:OBJECTIVE:The risk of cardiovascular death before the age of 40 is 20-fold higher in patients with type 1 diabetes mellitus (T1DM). Endothelial progenitor cells (EPCs) predict cardiovascular morbidity and mortality in patients without diabetes. We hypothesized that EPCs are modified in children with T1DM and are relate...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Hörtenhuber T,Rami-Mehar B,Satler M,Nagl K,Höbaus C,Höllerl F,Koppensteiner R,Schernthaner G,Schober E,Schernthaner GH

    更新日期:2013-06-01 00:00:00

  • Peripheral Neuropathy and Nerve Dysfunction in Individuals at High Risk for Type 2 Diabetes: The PROMISE Cohort.

    abstract:OBJECTIVE:Emerging evidence suggests that peripheral neuropathy begins in the early stages of diabetes pathogenesis. Our objective was to describe the prevalence of peripheral neuropathy and nerve dysfunction according to glucose tolerance and metabolic syndrome status and examine how these conditions are associated wi...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Lee CC,Perkins BA,Kayaniyil S,Harris SB,Retnakaran R,Gerstein HC,Zinman B,Hanley AJ

    更新日期:2015-05-01 00:00:00

  • Risk factors predicting lower extremity amputations in patients with NIDDM.

    abstract:OBJECTIVE:To examine the predictors of lower extremity amputation in patients with NIDDM. RESEARCH DESIGN AND METHODS:At baseline, risk factors for amputation were determined in 1,044 NIDDM patients (571 men, 473 women) aged 45 to 64 years. These patients were followed up to 7 years with respect to amputation. RESULT...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lehto S,Rönnemaa T,Pyörälä K,Laakso M

    更新日期:1996-06-01 00:00:00

  • Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

    abstract::The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists considerable heterogeneity: disease onset spans the complete age range; genetic susceptibility is compl...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Battaglia M,Ahmed S,Anderson MS,Atkinson MA,Becker D,Bingley PJ,Bosi E,Brusko TM,DiMeglio LA,Evans-Molina C,Gitelman SE,Greenbaum CJ,Gottlieb PA,Herold KC,Hessner MJ,Knip M,Jacobsen L,Krischer JP,Long SA,Lundgren M

    更新日期:2020-01-01 00:00:00

  • Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes.

    abstract:OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Clarke GD,Solis-Herrera C,Molina-Wilkins M,Martinez S,Merovci A,Cersosimo E,Chilton RJ,Iozzo P,Gastaldelli A,Abdul-Ghani M,DeFronzo RA

    更新日期:2017-11-01 00:00:00

  • Trunk versus extremity adiposity and cardiometabolic risk factors in white and African American adults.

    abstract:OBJECTIVE:To determine contributions of trunk and extremity adiposity to cardiometabolic risk factors (blood pressure, fasting blood glucose, HDL cholesterol, and triglycerides) among white and African American adults. RESEARCH DESIGN AND METHODS:The sample consisted of 1,129 white women, 779 African American women, 1...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Hu G,Bouchard C,Bray GA,Greenway FL,Johnson WD,Newton RL Jr,Ravussin E,Ryan DH,Katzmarzyk PT

    更新日期:2011-06-01 00:00:00

  • Diabetes complications and mortality among Alaska Natives: 8 years of observation.

    abstract:OBJECTIVE:To determine the prevalence and incidence of diabetes in Alaska Natives and the incidence of cerebrovascular accidents (stroke), myocardial infarction (MI), end-stage renal disease (ESRD), lower-extremity amputations (LEA), and mortality over a 6- to 8-year period. RESEARCH DESIGN AND METHODS:The data derive...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schraer CD,Adler AI,Mayer AM,Halderson KR,Trimble BA

    更新日期:1997-03-01 00:00:00

  • Controversies for Glucose Control Targets in Type 2 Diabetes: Exposing the Common Ground.

    abstract::Glycated hemoglobin targets have been given in guidelines for the last three decades, mostly without change at around 6.5-7.0% (47-53 mmol/mol). Personalization of such targets has also long been advocated, but often with little and inappropriate guidance. More recently some have suggested higher targets might be indi...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Home P

    更新日期:2019-09-01 00:00:00

  • Metformin and exercise in type 2 diabetes: examining treatment modality interactions.

    abstract:OBJECTIVE:To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS:Ten participants with type ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Boulé NG,Robert C,Bell GJ,Johnson ST,Bell RC,Lewanczuk RZ,Gabr RQ,Brocks DR

    更新日期:2011-07-01 00:00:00

  • Impact of peripheral neuropathy on bone density in patients with type 1 diabetes.

    abstract:OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Rix M,Andreassen H,Eskildsen P

    更新日期:1999-05-01 00:00:00