Is pregnancy in diabetic women associated with folate deficiency?

Abstract:

OBJECTIVE:To determine whether folate metabolism in pregnant diabetic women is significantly different from that in pregnant nondiabetic women, thus predisposing them to having offspring with major congenital anomalies. RESEARCH DESIGN AND METHODS:A total of 31 pregnant diabetic women and 54 pregnant nondiabetic control subjects were studied at their first prenatal visits. Dietary folate intake, serum folate, red blood cell folate, urinary folate, and homocysteine were measured and compared after controlling for folate supplementation. Among diabetic women the relationships among parameters of folate metabolism and glycemic control were also assessed. RESULTS:There were no significant differences between the pregnant diabetic and non-diabetic women for any measures of folate metabolism after accounting for folate supplementation. In addition, among diabetic women, there were no associations among parameters of folate metabolism and glycemic control. CONCLUSIONS:Abnormal folate metabolism does not appear to occur in pregnant diabetic women. It is unlikely that deranged folate metabolism explains the higher incidence of major anomalies in infants of diabetic mothers. These results do not diminish the importance of periconception folate supplementation or preclude other possible scenarios that could restrict folate use by the embryo, leading to congenital anomalies.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Kaplan JS,Iqbal S,England BG,Zawacki CM,Herman WH

doi

10.2337/diacare.22.7.1017

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

1017-21

issue

7

eissn

0149-5992

issn

1935-5548

journal_volume

22

pub_type

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