Altered postprandial insulin requirement in IDDM patients with gastroparesis.

abstract：OBJECTIVE:Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We a...

journal_title：Diabetes care

authors： Campbell-Thompson ML,Filipp SL,Grajo JR,Nambam B,Beegle R,Middlebrooks EH,Gurka MJ,Atkinson MA,Schatz DA,Haller MJ

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Strict glycemic control in people with insulin-dependent diabetes mellitus (IDDM) reduces the risk of microvascular complications, but improvements in control are also associated with weight gain. Fears about the mortality risks of obesity may limit the acceptability of tight control. Therefore, we examined m...

journal_title：Diabetes care

authors： Chaturvedi N,Stevens LK,Fuller JH

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:Although initially effective, sulfonylureas are associated with poor glycemic durability, weight gain, and hypoglycemia. Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduces hyperglycemia by increasing urinary glucose excretion independent of insulin and may cause fewer of t...

journal_title：Diabetes care

authors： Nauck MA,Del Prato S,Meier JJ,Durán-García S,Rohwedder K,Elze M,Parikh SJ

更新日期：2011-09-01 00:00:00

abstract：:Morphologic characteristics of insulin precipitates were examined by both scanning and transmission electron microscopy. Insulin precipitate obtained after 1 wk of in vivo storage in an implanted dog reservoir was compared with insulin precipitate produced in vitro by isoelectric precipitation, acid-freeze-heat precip...

journal_title：Diabetes care

authors： Schade DS,Eaton RP,DeLongo J,Saland LC,Ladman AJ,Carlson GA

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics and glucodynamics of a new insulin analog, insulin lispro, and regular human insulin were compared and contrasted after subcutaneous administrations in femoral, deltoid, and abdominal injection sites. RESEARCH DESIGN AND METHODS:Single 0.2 U/kg doses of insulin lispro and regular insulin...

journal_title：Diabetes care

authors： ter Braak EW,Woodworth JR,Bianchi R,Cerimele B,Erkelens DW,Thijssen JH,Kurtz D

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:To determine the effect of diabetes on thyroid hormone and thyroxine-binding globulin (TBG) concentrations during puberty. RESEARCH DESIGN AND METHODS:Total thyroxine (TT4), free thyroxine (FT4), and TBG levels of 171 thyroid microsomal antibody-negative subjects with normal thyroid-stimulating hormone (TSH)...

journal_title：Diabetes care

authors： Connors MH,Dunger DB,Chapel H,Jefferson I,Jowett TP,Edwards PR

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To examine the association of renal function in diabetic patients with apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:Apo E genotypes, lipid and lipoprotein serum levels, creatinine clearance (CCr), and excretion of marker proteins were determined in German type 1 (IDDM; n = 162) and type 2...

journal_title：Diabetes care

authors： Werle E,Fiehn W,Hasslacher C

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Platelet hyperfunction is a typical feature of the prothrombotic state that frequently complicates the natural history of diabetes. In uremia, a bleeding diathesis is present, which principally involves the primary phase of hemostasis. Thus, in patients with uremia of diabetic origin, the infrequent coexisten...

journal_title：Diabetes care

authors： Vicari AM,Taglietti MV,Pellegatta F,Spotti D,Melandri M,Galli L,Ronchi P,Folli F

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To determine the fatty acid composition of serum phospholipid, triglyceride, and cholesterol ester fractions and to analyze the lipid profile of microalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A case-control study was conducted with 72 patients: 37 were normoalbuminuric (urinary albumi...

journal_title：Diabetes care

authors： Perassolo MS,Almeida JC,Prá RL,Mello VD,Maia AL,Moulin CC,Camargo JL,Zelmanovitz T,Azevedo MJ,Gross JL

更新日期：2003-03-01 00:00:00

abstract：:Nocturnal hypoglycemia in insulin-treated diabetic persons is often difficult to recognize clinically. It has been suggested that a useful biochemical test to demonstrate this would be the increased excretion of cortisol in the urine during the overnight period. However, of six diabetic persons who had nocturnal hypog...

journal_title：Diabetes care

authors： Scott RS,Scandrett MS

更新日期：1981-09-01 00:00:00

abstract：OBJECTIVE:To determine whether a culturally appropriate clinic- and community-based intervention for African-American women with type 2 diabetes will increase moderate-intensity physical activity (PA). RESEARCH DESIGN AND METHODS:In this randomized controlled trial conducted at seven practices in central North Carolin...

journal_title：Diabetes care

authors： Keyserling TC,Samuel-Hodge CD,Ammerman AS,Ainsworth BE,Henríquez-Roldán CF,Elasy TA,Skelly AH,Johnston LF,Bangdiwala SI

更新日期：2002-09-01 00:00:00

abstract：:The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of...

journal_title：Diabetes care

authors： Lewis GF,Steiner G

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...

journal_title：Diabetes care

authors： Rajpathak SN,Wassertheil-Smoller S,Crandall J,Liu S,Ho GY

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of ginseng on newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:In this double-blind placebo-controlled study, 36 NIDDM patients were treated for 8 weeks with ginseng (100 or 200 mg) or placebo. Efficacy was evaluated with psychoph...

journal_title：Diabetes care

authors： Sotaniemi EA,Haapakoski E,Rautio A

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:To address whether hemodynamic responses in the cerebral arteries and OAs may be altered in patients with diabetic retinopathy. We used TCD to evaluate the effects of changes in BP, posture, and exercise on MCA and OA blood flow velocities. RESEARCH DESIGN AND METHODS:We evaluated 13 patients with BDR, 19 wi...

journal_title：Diabetes care

authors： Albert SG,Gomez CR,Russell S,Chaitman BR,Bernbaum M,Kong BA

更新日期：1993-02-01 00:00:00

abstract：:Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...

journal_title：Diabetes care

authors： Rosskamp RH,Park G

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to identify predictors of the onset of disturbed eating behavior (DEB) in adolescent girls with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective study, participants completed the Children's Eating Disorder Examination interview and self-report measures at baselin...

journal_title：Diabetes care

authors： Olmsted MP,Colton PA,Daneman D,Rydall AC,Rodin GM

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Levels of AGE-LDL and oxLDL in ICs were measured i...

journal_title：Diabetes care

authors： Lopes-Virella MF,Baker NL,Hunt KJ,Lyons TJ,Jenkins AJ,Virella G,DCCT\/EDIC Study Group.

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To examine whether the association between gestational diabetes mellitus (GDM) and BMI category varies by racial/ethnic group. RESEARCH DESIGN AND METHODS:In a cohort of 123,040 women without recognized pregravid diabetes who delivered babies between 1995 and 2006 at Kaiser Permanente of Northern California,...

journal_title：Diabetes care

authors： Hedderson M,Ehrlich S,Sridhar S,Darbinian J,Moore S,Ferrara A

更新日期：2012-07-01 00:00:00

abstract：:Unexpected plasma glucose responses to different mixed meals fed to normal and diabetic volunteers have recently been reported. We have therefore examined in normal volunteers the effect of mixing carbohydrate foods of different glycemic indices (GIs) without the addition of fat and protein. The observed GI of the mix...

journal_title：Diabetes care

authors： Wolever TM,Nuttall FQ,Lee R,Wong GS,Josse RG,Csima A,Jenkins DJ

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). Obstructive sleep apnea (OSA) is common in type 2 diabetes and increases oxidative stress. Hence, OSA could promote the development and progression of DN. RESEARCH DESIGN AND METHODS:This was a cohort study in adults with type 2 ...

journal_title：Diabetes care

authors： Tahrani AA,Ali A,Raymond NT,Begum S,Dubb K,Altaf QA,Piya MK,Barnett AH,Stevens MJ

更新日期：2013-11-01 00:00:00

abstract：:Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...

journal_title：Diabetes care

authors： Rovet JF,Ehrlich RM

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To assess the costs and project the potential lifetime cost-effectiveness of the ongoing Autoimmunity Screening for Kids (ASK) program, a large-scale, presymptomatic type 1 diabetes screening program for children and adolescents in the metropolitan Denver region. RESEARCH DESIGN AND METHODS:We report the res...

journal_title：Diabetes care

authors： McQueen RB,Geno Rasmussen C,Waugh K,Frohnert BI,Steck AK,Yu L,Baxter J,Rewers M

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...

journal_title：Diabetes care

authors： Scott RS,Brown LJ,Darlow BA,Forbes LV,Moore MP

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:This study evaluated the feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS:In an open-label randomized crossover study, 12 suboptimally controlled adolescents on insulin pump the...

journal_title：Diabetes care

authors： Tauschmann M,Allen JM,Wilinska ME,Thabit H,Acerini CL,Dunger DB,Hovorka R

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in ty...

journal_title：Diabetes care

authors： Hermansen K,Søndergaard M,Høie L,Carstensen M,Brock B

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...

journal_title：Diabetes care

authors： Clarke GD,Solis-Herrera C,Molina-Wilkins M,Martinez S,Merovci A,Cersosimo E,Chilton RJ,Iozzo P,Gastaldelli A,Abdul-Ghani M,DeFronzo RA

更新日期：2017-11-01 00:00:00

abstract：:The relationship of two aspects of family life to metabolic control were examined as part of a longitudinal study of school-aged children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Glycosylated hemoglobin level was the primary index of metabolic control; weight-adjusted insulin dosage served as a...

journal_title：Diabetes care

authors： Kovacs M,Kass RE,Schnell TM,Goldston D,Marsh J

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:Diabetes has been associated with chronic neurodegeneration. We performed a systematic review and meta-analysis to assess the relationship between pre-existing diabetes and Parkinson's disease (PD). RESEARCH DESIGN AND METHODS:Original articles in English published up to 10 May 2011 were searched for in elec...

journal_title：Diabetes care

authors： Cereda E,Barichella M,Pedrolli C,Klersy C,Cassani E,Caccialanza R,Pezzoli G

更新日期：2011-12-01 00:00:00

abstract：:We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intens...

journal_title：Diabetes care

authors： Rosenstock J,Strowig S,Cercone S,Raskin P

更新日期：1987-11-01 00:00:00