Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.

Abstract:

OBJECTIVE:The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS:Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-based random sample of men aged 40-70. Of the 1,709 men enrolled in 1987-1989 (T1), 1,156 were followed up 7-10 years later (T2). Testosterone and SHBG levels at T1 were used to predict new cases of diabetes between T1 and T2. RESULTS:After controlling for potential confounders, diabetes at follow-up was predicted jointly and independently by lower baseline levels of free testosterone and SHBG. The odds ratio for future diabetes was 1.58 for a decrease of 1SD in free testosterone (4 ng/dl) and 1.89 for a 1SD decrease in SHBG (16 nmol/l), both significant at P < 0.02. CONCLUSIONS:Our prospective findings are consistent with previous, mainly cross-sectional reports, suggesting that low levels of testosterone and SHBG play some role in the development of insulin resistance and subsequent type 2 diabetes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Stellato RK,Feldman HA,Hamdy O,Horton ES,McKinlay JB

doi

10.2337/diacare.23.4.490

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

490-4

issue

4

eissn

0149-5992

issn

1935-5548

journal_volume

23

pub_type

杂志文章
  • Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion.

    abstract:OBJECTIVE:N-acetylglucosamine/galactosamine (GlycA) and sialic acid (GlycB) moieties of glycosylated serum proteins are nonspecific measures of inflammation, but conclusive data on their relationship with insulin resistance or insulin secretion are missing. Therefore, we aimed to examine the relation of GlycA, GlycB, a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-1569

    authors: Lorenzo C,Festa A,Hanley AJ,Rewers MJ,Escalante A,Haffner SM

    更新日期:2017-03-01 00:00:00

  • Quality of care and outcomes in type 2 diabetic patients: a comparison between general practice and diabetes clinics.

    abstract:OBJECTIVE:The role of general practice and diabetes clinics in the management of diabetes is still a matter of debate. Methodological flaws in previous studies may have led to inaccurate conclusions when comparing the care provided in these different settings. We compared the care provided to type 2 diabetic patients a...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.27.2.398

    authors: De Berardis G,Pellegrini F,Franciosi M,Belfiglio M,Di Nardo B,Greenfield S,Kaplan SH,Rossi MC,Sacco M,Tognoni G,Valentini M,Nicolucci A,QuED Study.

    更新日期:2004-02-01 00:00:00

  • Conduction slowing in diabetic sensorimotor polyneuropathy.

    abstract:OBJECTIVE:Mild demyelination may contribute more to the pathophysiology of nerve fiber injury in diabetic sensorimotor polyneuropathy (DSP) than previously thought. We investigated the clinical and electrodiagnostic classifications of nerve injury in diabetic patients to detect evidence of conduction slowing in DSP. R...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0746

    authors: Dunnigan SK,Ebadi H,Breiner A,Katzberg HD,Lovblom LE,Perkins BA,Bril V

    更新日期:2013-11-01 00:00:00

  • Diabetes care in health maintenance organizations.

    abstract::An increasing amount of health care today is directed to the amelioration of chronic diseases for which there are no cures. Technological advances and the aging of the population have increased the costs of that care. In an attempt to control costs and increase the efficiency of health care, it is being increasingly d...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.15.1.s44

    authors: Geffner DL

    更新日期:1992-03-01 00:00:00

  • Collaborative care management of major depression among low-income, predominantly Hispanic subjects with diabetes: a randomized controlled trial.

    abstract:OBJECTIVE:To determine whether evidence-based socioculturally adapted collaborative depression care improves receipt of depression care and depression and diabetes outcomes in low-income Hispanic subjects. RESEARCH DESIGN AND METHODS:This was a randomized controlled trial of 387 diabetic patients (96.5% Hispanic) with...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1711

    authors: Ell K,Katon W,Xie B,Lee PJ,Kapetanovic S,Guterman J,Chou CP

    更新日期:2010-04-01 00:00:00

  • Challenges to healthy eating for people with diabetes in a low-income, minority neighborhood.

    abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1632

    authors: Breland JY,McAndrew LM,Gross RL,Leventhal H,Horowitz CR

    更新日期:2013-10-01 00:00:00

  • 9. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2018.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc18-S009

    authors: American Diabetes Association.

    更新日期:2018-01-01 00:00:00

  • Impact of diabetes among revascularized patients in Japan and the U.S.

    abstract:OBJECTIVE:Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetes may differ according to ethnicit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1547

    authors: Kohsaka S,Goto M,Nagai T,Lee VV,Elayda M,Furukawa Y,Fukushima M,Komeda M,Sakata R,Ohsugi M,Fukuda K,Wilson JM,Kita T,Kimura T

    更新日期:2012-03-01 00:00:00

  • In patients with acute myocardial infarction, the impact of hyperglycemia as a risk factor for mortality is not homogeneous across age-groups.

    abstract:OBJECTIVE:To assess the impact of hyperglycemia in different age-groups of patients with acute myocardial infarction (AMI). RESEARCH DESIGN AND METHODS:A total of 2,027 patients with AMI were categorized into one of five age-groups: <50 years (n = 301), ≥50 and <60 (n = 477), ≥60 and <70 (n = 545), ≥70 and <80 (n = 49...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1170

    authors: Nicolau JC,Serrano CV Jr,Giraldez RR,Baracioli LM,Moreira HG,Lima F,Franken M,Kalil R,Ramires JA,Giugliano RP

    更新日期:2012-01-01 00:00:00

  • Prognostic value of resting heart rate on cardiovascular and renal outcomes in type 2 diabetic patients: a competing risk analysis in a prospective cohort.

    abstract:OBJECTIVE:Epidemiological studies and randomized clinical trials have demonstrated in various populations that resting heart rate (RHR) was an independent predictor of cardiovascular (CV) risk and all-cause mortality. However, few data specifically evaluated the relationship between RHR and long-term CV and renal compl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2468

    authors: Miot A,Ragot S,Hammi W,Saulnier PJ,Sosner P,Piguel X,Torremocha F,Marechaud R,Hadjadj S

    更新日期:2012-10-01 00:00:00

  • Relationship of blood thromboxane-B2 (TxB2) with lipid peroxides and effect of vitamin E and placebo supplementation on TxB2 and lipid peroxide levels in type 1 diabetic patients.

    abstract:OBJECTIVE:To study the effect of vitamin E supplementation on platelet hyperaggregability in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:Written informed consent according to the Institutional Review Board on Human Experimentation guidelines was obtained from diabetic patients (n = 29) and their age-matched ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.21.9.1511

    authors: Jain SK,Krueger KS,McVie R,Jaramillo JJ,Palmer M,Smith T

    更新日期:1998-09-01 00:00:00

  • The prevalence and predictors of an abnormal ankle-brachial index in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

    abstract:OBJECTIVE:To examine ankle-brachial index (ABI) abnormalities in patients with type 2 diabetes and coronary artery disease (CAD). RESEARCH DESIGN AND METHODS:An ABI was obtained in 2,240 patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. ABIs were classified as: normal, 0.91...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1734

    authors: Singh PP,Abbott JD,Lombardero MS,Sutton-Tyrrell K,Woodhead G,Venkitachalam L,Tsapatsaris NP,Piemonte TC,Lago RM,Rutter MK,Nesto RW,Bypass Angioplasty Revascularization Investigation 2 Diabetes Study Group.

    更新日期:2011-02-01 00:00:00

  • Correlation of fingerstick blood glucose measurements with GlucoWatch biographer glucose results in young subjects with type 1 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.22.10.1708

    authors: Garg SK,Potts RO,Ackerman NR,Fermi SJ,Tamada JA,Chase HP

    更新日期:1999-10-01 00:00:00

  • Remissions of diabetes mellitus after weight reduction by jejunoileal bypass.

    abstract::Limited weight loss following jejunoileal bypass in 24 diabetic persons who were still distinctly overweight five to ten months after a mean weight decrease of 78 lbs. was accompanied by a return of normal fasting glucose and insulin levels, normal insulin responses, and a decrease in glucose intolerance. The glucose ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.1.3.158

    authors: Ahmad U,Danowski TS,Nolan S,Stephan T,Sunder JH,Bahl VK

    更新日期:1978-05-01 00:00:00

  • The efficacy and safety of human insulin (Novo) in insulin-dependent diabetic patients.

    abstract::Fifty-one insulin-dependent diabetic patients, 26 children and 25 adults, participated in an open uncontrolled study of the safety and efficacy of human insulin (Novo). The patients, who had previously been treated exclusively with porcine insulin, were followed in two outpatient clinics during a 3-mo study period. Du...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:

    authors: Lyngsøe J,Vestermark S

    更新日期:1983-03-01 00:00:00

  • The community ecology of diabetes patient classification and practice characteristics.

    abstract::We examined the clinical and epidemiologic characteristics of diabetic subjects ascertained from five different sources (hospital, private practice, specialist practice, nursing home, and prevalence survey) in a medium-sized upstate New York community. Patients were categorized using the National Diabetes Data Group c...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.1.s87

    authors: Rothenberg RB,Olsen CL,Schnure JJ,Gerber TM,Cohen J,Curtis GB,Jesserer J,Roach J,Wirth C

    更新日期:1985-09-01 00:00:00

  • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

    abstract:OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.9.1462

    authors: Matsuda M,DeFronzo RA

    更新日期:1999-09-01 00:00:00

  • Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66.

    abstract:OBJECTIVE:Patients with diabetes have a higher case fatality rate in myocardial infarction (MI) or stroke than those without diabetes: that is, MI and stroke are more often fatal if diabetes is present. We investigated whether the risk of MI or stroke being fatal in type 2 diabetes can be estimated using information av...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.27.1.201

    authors: Stevens RJ,Coleman RL,Adler AI,Stratton IM,Matthews DR,Holman RR

    更新日期:2004-01-01 00:00:00

  • Diastolic function is reduced in adolescents with type 1 diabetes in response to exercise.

    abstract:OBJECTIVE:To determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration. RESEARCH DESIGN AND METHODS:The study evaluated 53 adolescents with type 1 diabetes and 22 contro...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2331

    authors: Gusso S,Pinto TE,Baldi JC,Robinson E,Cutfield WS,Hofman PL

    更新日期:2012-10-01 00:00:00

  • Random blood glucose measurement at antenatal booking to screen for overt diabetes in pregnancy: a retrospective study.

    abstract:OBJECTIVE:To assess random venous blood glucose (RBG) measurement at antenatal booking to detect "overt diabetes in pregnancy" (ODIP). RESEARCH DESIGN AND METHODS:A retrospective analysis of regional hospital obstetric data from 2004-2008 was performed. Universal RBG screening was included at booking. Oral glucose tol...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0533

    authors: Church D,Halsall D,Meek C,Parker RA,Murphy HR,Simmons D

    更新日期:2011-10-01 00:00:00

  • The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients.

    abstract:OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, al...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.11.1200

    authors: Juntti-Berggren L,Pigon J,Karpe F,Hamsten A,Gutniak M,Vignati L,Efendic S

    更新日期:1996-11-01 00:00:00

  • Can adoption of regular exercise later in life prevent metabolic risk for cardiovascular disease?

    abstract:OBJECTIVE:To determine the impact of chronic exercise training initiated later in life upon development of metabolic markers of cardiovascular disease risk. RESEARCH DESIGN AND METHODS:Two inception cohorts of previously sedentary healthy adults aged 55-75 years at baseline (1989), one initiating regular supervised ph...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.28.3.694

    authors: Petrella RJ,Lattanzio CN,Demeray A,Varallo V,Blore R

    更新日期:2005-03-01 00:00:00

  • High calorie intake is associated with worsening insulin resistance and β-cell function in Hispanic women after gestational diabetes mellitus.

    abstract:OBJECTIVE:To assess associations between dietary intake and rates of change in insulin resistance and β-cell function in Hispanic women with prior gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Sixty-two nondiabetic Hispanic women with pregnancies complicated by GDM completed oral and intravenous glu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1433

    authors: Chen Z,Watanabe RM,Stram DO,Buchanan TA,Xiang AH

    更新日期:2014-12-01 00:00:00

  • Association of lipoprotein(a) with puberty in IDDM.

    abstract:OBJECTIVE:To determine serum lipoprotein(a) in a large sample of IDDM and control children and to examine a possible association with puberty. RESEARCH DESIGN AND METHODS:Serum lipoprotein(a), apoB-100, and apoA-I were measured under identical conditions in 170 Caucasian children with IDDM aged 12.3 +/- 3.59 yr and 23...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.6.869

    authors: Couper JJ,Bates DJ,Cocciolone R,Magarey AM,Boulton TJ,Penfold JL,Ryall RG

    更新日期:1993-06-01 00:00:00

  • Electron microscopy of insulin precipitates.

    abstract::Morphologic characteristics of insulin precipitates were examined by both scanning and transmission electron microscopy. Insulin precipitate obtained after 1 wk of in vivo storage in an implanted dog reservoir was compared with insulin precipitate produced in vitro by isoelectric precipitation, acid-freeze-heat precip...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.1.25

    authors: Schade DS,Eaton RP,DeLongo J,Saland LC,Ladman AJ,Carlson GA

    更新日期:1982-01-01 00:00:00

  • Stroke in the diabetic patient.

    abstract::A higher prevalence of stroke is found in the patient with both diagnosed and undiagnosed diabetes and glucose intolerance. Because of local cerebral acidosis caused by ischemia and hyperglycemia, morbidity and mortality from a stroke are increased. Most studies show that individuals with admission serum glucose > 120...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.17.3.213

    authors: Bell DS

    更新日期:1994-03-01 00:00:00

  • Evaluation of Factors Related to Glycemic Management in Professional Cyclists With Type 1 Diabetes Over a 7-Day Stage Race.

    abstract:OBJECTIVE:To investigate factors related to glycemic management among members of a professional cycling team with type 1 diabetes over a 7-day Union Cycliste Internationale World Tour stage race. RESEARCH DESIGN AND METHODS:An observational evaluation of possible factors related to glycemic management and performance ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2302

    authors: Scott SN,Christiansen MP,Fontana FY,Stettler C,Bracken RM,Hayes CA,Fisher M,Bode B,Lagrou PH,Southerland P,Riddell MC

    更新日期:2020-05-01 00:00:00

  • Intensive insulin therapy for treatment of type I diabetes.

    abstract::Intensive insulin therapy is best defined as a comprehensive system of diabetes management with the patient and management team as partners. The system is directed at improvement of glycemia and patient well-being. Glycemic targets should be individually defined. Frequent self-monitoring of blood glucose, probably at ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.13.12.1265

    authors: Hirsch IB,Farkas-Hirsch R,Skyler JS

    更新日期:1990-12-01 00:00:00

  • Prospective evaluation of HDL cholesterol changes after diet and physical conditioning programs for patients with type II diabetes mellitus.

    abstract::High-density lipoprotein (HDL) cholesterol is known to be low in patients with diabetes mellitus. Low HDL levels are correlated with premature cardiovascular mortality in several major epidemiologic studies and many investigators believe increases in HDL cholesterol may reduce the risk of coronary heart disease. We ev...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.8.4.343

    authors: Kaplan RM,Wilson DK,Hartwell SL,Merino KL,Wallace JP

    更新日期:1985-07-01 00:00:00

  • Effect of weight loss with lifestyle intervention on risk of diabetes.

    abstract:OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS par...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-0560

    authors: Hamman RF,Wing RR,Edelstein SL,Lachin JM,Bray GA,Delahanty L,Hoskin M,Kriska AM,Mayer-Davis EJ,Pi-Sunyer X,Regensteiner J,Venditti B,Wylie-Rosett J

    更新日期:2006-09-01 00:00:00