Differences in Regional Brain Responses to Food Ingestion After Roux-en-Y Gastric Bypass and the Role of Gut Peptides: A Neuroimaging Study.


OBJECTIVE:Improved appetite control, possibly mediated by exaggerated gut peptide responses to eating, may contribute to weight loss after Roux-en-Y gastric bypass (RYGB). This study compared brain responses to food ingestion between post-RYGB (RYGB), normal weight (NW), and obese (Ob) unoperated subjects and explored the role of gut peptide responses in RYGB. RESEARCH DESIGN AND METHODS:Neuroimaging with [(18)F]-fluorodeoxyglucose (FDG) positron emission tomography was performed in 12 NW, 21 Ob, and 9 RYGB (18 ± 13 months postsurgery) subjects after an overnight fast, once FED (400 kcal mixed meal), and once FASTED, in random order. RYGB subjects repeated the studies with somatostatin infusion and basal insulin replacement. Fullness, sickness, and postscan ad libitum meal consumption were measured. Regional brain FDG uptake was compared using statistical parametric mapping. RESULTS:RYGB subjects had higher overall fullness and food-induced sickness and lower ad libitum consumption. Brain responses to eating differed in the hypothalamus and pituitary (exaggerated activation in RYGB), left medial orbital cortex (OC) (activation in RYGB, deactivation in NW), right dorsolateral frontal cortex (deactivation in RYGB and NW, absent in Ob), and regions mapping to the default mode network (exaggerated deactivation in RYGB). Somatostatin in RYGB reduced postprandial gut peptide responses, sickness, and medial OC activation. CONCLUSIONS:RYGB induces weight loss by augmenting normal brain responses to eating in energy balance regions, restoring lost inhibitory control, and altering hedonic responses. Altered postprandial gut peptide responses primarily mediate changes in food-induced sickness and OC responses, likely to associate with food avoidance.


Diabetes Care


Diabetes care


Hunt KF,Dunn JT,le Roux CW,Reed LJ,Marsden PK,Patel AG,Amiel SA




Has Abstract


2016-10-01 00:00:00














  • Temporal variation in incidence of IDDM in Canterbury, New Zealand.

    abstract:OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Scott RS,Brown LJ,Darlow BA,Forbes LV,Moore MP

    更新日期:1992-07-01 00:00:00

  • The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration.

    abstract:OBJECTIVE:To promote foot screening of inpatients with diabetes, we simplified sensory testing to lightly touching the tips of the first, third, and fifth toes (the Ipswich Touch Test [IpTT]). RESEARCH DESIGN AND METHODS:Respective performances of the IpTT and 10-g monofilament (MF) were compared with a vibration perc...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Rayman G,Vas PR,Baker N,Taylor CG Jr,Gooday C,Alder AI,Donohoe M

    更新日期:2011-07-01 00:00:00

  • Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study.

    abstract:OBJECTIVE:HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explore...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Muhammad IF,Borné Y,Bao X,Melander O,Orho-Melander M,Nilsson PM,Nilsson J,Engström G

    更新日期:2019-08-01 00:00:00

  • Treatment of osteomyelitis in the diabetic foot. Contribution of conservative surgery.

    abstract:OBJECTIVE:To compare the duration of healing of foot ulcers with osteomyelitis in diabetic patients treated by medical treatment versus medical treatment associated with conservative orthopedic surgery. RESEARCH DESIGN AND METHODS:We entered into the study 67 diabetic patients who had a foot ulcer with osteomyelitis w...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Ha Van G,Siney H,Danan JP,Sachon C,Grimaldi A

    更新日期:1996-11-01 00:00:00

  • Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients.

    abstract:OBJECTIVE:The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients. RESEARCH DESIGN AND METHODS:There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurem...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Freccero C,Svensson H,Bornmyr S,Wollmer P,Sundkvist G

    更新日期:2004-12-01 00:00:00

  • Initiating exercise programs for patients with non-insulin-dependent diabetes.

    abstract::Considerable attention has been focused on the importance of physical activity in improving the diabetic state in obese, non-insulin-dependent diabetic patients. Because this patient population tends to be sedentary, this challenge requires an active effort involving the patient and health-care providers. The latter m...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Beeken RK

    更新日期:1980-09-01 00:00:00

  • Reduced albuminuria during early and aggressive antihypertensive treatment of insulin-dependent diabetic patients with diabetic nephropathy.

    abstract::Urinary albumin excretion rate (radial immunodiffusion), glomerular filtration rate (GFR) (single-shot 51Cr-EDTA technique), and arterial blood pressure (BP) were measured in 12 juvenile-onset, insulin-dependent diabetic patients with persistent proteinuria (greater than 0.5 g/day) due to diabetic nephropathy. Mean ag...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Parving HH,Andersen AR,Smidt UM,Friisberg B,Svendsen PA

    更新日期:1981-07-01 00:00:00

  • Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy.

    abstract:OBJECTIVE:To assess the dose-ranging efficacy and safety of LX4211, a dual inhibitor of sodium-glucose cotransporter (SGLT) 1 and SGLT2, in type 2 diabetes. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients inadequately controlled on metformin were randomly assigned to 75 mg once daily, 200 mg once daily, 200 mg tw...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rosenstock J,Cefalu WT,Lapuerta P,Zambrowicz B,Ogbaa I,Banks P,Sands A

    更新日期:2015-03-01 00:00:00

  • The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes.

    abstract:OBJECTIVE:To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Tansey MJ,Tsalikian E,Beck RW,Mauras N,Buckingham BA,Weinzimer SA,Janz KF,Kollman C,Xing D,Ruedy KJ,Steffes MW,Borland TM,Singh RJ,Tamborlane WV,Diabetes Research in Children Network (DirecNet) Study Group.

    更新日期:2006-01-01 00:00:00

  • Survey of physician practice behaviors related to diabetes mellitus in the U.S. Physician adherence to consensus recommendations.

    abstract:OBJECTIVE:To summarize the frequency of physician adherence to consensus recommendations for prevention of diabetic complications. RESEARCH DESIGN AND METHODS:Survey data from a nationwide stratified probability sample of primary-care physicians were analyzed. Adherence to recommendations were reported by physician sp...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kenny SJ,Smith PJ,Goldschmid MG,Newman JM,Herman WH

    更新日期:1993-11-01 00:00:00

  • ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population.

    abstract:OBJECTIVE:Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes i...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schou J,Tybjærg-Hansen A,Møller HJ,Nordestgaard BG,Frikke-Schmidt R

    更新日期:2012-12-01 00:00:00

  • Maternal serum triglyceride, glucose tolerance, and neonatal birth weight ratio in pregnancy.

    abstract:OBJECTIVE:To determine the value of measuring serum triglyceride (TG) levels early in pregnancy for predicting late-gestation glucose tolerance and neonatal birth weight ratio (BWR) (birth weight corrected for gestational age). RESEARCH DESIGN AND METHODS:The relationships between morning nonfasting TG measured early ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Nolan CJ,Riley SF,Sheedy MT,Walstab JE,Beischer NA

    更新日期:1995-12-01 00:00:00

  • Acute metabolic response to high-carbohydrate, high-starch meals compared with moderate-carbohydrate, low-starch meals in subjects with type 2 diabetes.

    abstract:OBJECTIVE:The monosaccharides resulting from the digestion of ingested carbohydrates are glucose, fructose, and galactose. Of these three monosaccharides, only ingested glucose resulted in a large increase in the plasma glucose concentration. Fructose (Metabolism 41:510-517, 1992) and galactose (Metabolism 42:1560-1567...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gannon MC,Nuttall FQ,Westphal SA,Fang S,Ercan-Fang N

    更新日期:1998-10-01 00:00:00

  • Repaglinide/troglitazone combination therapy: improved glycemic control in type 2 diabetes.

    abstract:OBJECTIVE:This multicenter open-label clinical trial compared the efficacy and safety of repaglinide/troglitazone combination therapy, repaglinide monotherapy, and troglitazone monotherapy in type 2 diabetes that had been inadequately controlled by sulfonylureas, acarbose, or metformin alone. RESEARCH DESIGN AND METHO...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Raskin P,Jovanovic L,Berger S,Schwartz S,Woo V,Ratner R

    更新日期:2000-07-01 00:00:00

  • Acute hypoglycemia impairs executive cognitive function in adults with and without type 1 diabetes.

    abstract:OBJECTIVE:Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management. This study examined the effect of acute hypoglycemia on executive function in adults with and without diabetes. RESEARCH DESIGN AND ME...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Graveling AJ,Deary IJ,Frier BM

    更新日期:2013-10-01 00:00:00

  • The effects of fenofibric acid alone and with statins on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia.

    abstract:OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dos...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Bays HE,Roth EM,McKenney JM,Kelly MT,Thakker KM,Setze CM,Obermeyer K,Sleep DJ

    更新日期:2010-09-01 00:00:00

  • Assessment of glycosylated hemoglobin measurement with sample collection papers.

    abstract::It would be advantageous to be able to measure glycosylated hemoglobin (GHb) from a sample of blood dried on paper and sent to the physician by the patient. Indeed, such a technique has been introduced by Isolab (Akron, OH). We tested the validity of the method to determine whether applying the blood to paper and imme...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Broussolle C,Saudek CD

    更新日期:1987-05-01 00:00:00

  • Impact of specific glucose-control strategies on microvascular and macrovascular outcomes in 58,000 adults with type 2 diabetes.

    abstract:OBJECTIVE:Comparative effectiveness research methods are used to compare the effect of four distinct glucose-control strategies on subsequent myocardial infarction and nephropathy in type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 58,000 adults with type 2 diabetes and A1C <7% (53 mmol/mol) while taking two or...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Neugebauer R,Fireman B,Roy JA,O'Connor PJ

    更新日期:2013-11-01 00:00:00

  • The effects of health beliefs on weight loss in individuals at high risk for NIDDM.

    abstract:OBJECTIVE:To determine whether perceived risk and other health beliefs held by individuals at high risk for developing NIDDM predict weight loss and behavior change during a behavioral weight loss program to reduce the risk of NIDDM. RESEARCH DESIGN AND METHODS:Health beliefs and objective risk factors for diabetes we...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Polley BA,Jakicic JM,Venditti EM,Barr S,Wing RR

    更新日期:1997-10-01 00:00:00

  • Affinity sensor: a new technique for developing implantable sensors for glucose and other metabolites.

    abstract::We describe affinity sensors for monitoring various metabolites in blood plasma by optical means. The principle of detection is similar to that used in radioimmunoassays and is based on the competitive binding of a particular metabolite and a fluorescein-labeled analogue with receptor sites specific for the metabolite...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schultz JS,Mansouri S,Goldstein IJ

    更新日期:1982-05-01 00:00:00

  • Assessment of the psychological factors and responses in self-managed patients.

    abstract::In past studies on the psychological aspects of diabetes mellitus, symptoms of depression have been identified as the most common manifestation among diabetic patients. Other psychological manifestations have been anxiety, hypochondriasis, increased dependence and passivity, and poor self-image. Ten insulin-dependent ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Dupuis A

    更新日期:1980-01-01 00:00:00

  • The validation of a diabetes patient knowledge test.

    abstract::Diabetes knowledge tests, used in conjunction with measures of patient attitudes and behaviors, can provide a useful basis for assessing educational needs and designing appropriate instructional experiences. Accurate decisions require instruments that measure patient knowledge of diabetes and its management with high ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Hess GE,Davis WK

    更新日期:1983-11-01 00:00:00

  • Quantitative estimation of insulin sensitivity in type 1 diabetic subjects wearing a sensor-augmented insulin pump.

    abstract:OBJECTIVE:The goal was to develop a new index of insulin sensitivity in patients with type 1 diabetes estimated from continuous glucose monitoring (CGM) and subcutaneous insulin delivery data under carefully controlled conditions. RESEARCH DESIGN AND METHODS:The database consists of 12 subjects with type 1 diabetes, s...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Schiavon M,Dalla Man C,Kudva YC,Basu A,Cobelli C

    更新日期:2014-01-01 00:00:00

  • An analysis of dynamic forces transmitted through the foot in diabetic neuropathy.

    abstract:OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Shaw JE,van Schie CH,Carrington AL,Abbott CA,Boulton AJ

    更新日期:1998-11-01 00:00:00

  • Beneficial effects of a Dietary Approaches to Stop Hypertension eating plan on features of the metabolic syndrome.

    abstract:OBJECTIVE:To determine the effects of a Dietary Approaches to Stop Hypertension (DASH) eating plan on metabolic risks in patients with the metabolic syndrome. RESEARCH DESIGN AND METHODS:This was a randomized controlled outpatient trial conducted on 116 patients with the metabolic syndrome. Three diets were prescribed...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Azadbakht L,Mirmiran P,Esmaillzadeh A,Azizi T,Azizi F

    更新日期:2005-12-01 00:00:00

  • Total sialic acid and associated elements of the metabolic syndrome in women with and without previous gestational diabetes.

    abstract:OBJECTIVE:Inflammatory markers predict type 2 diabetes and relate to the metabolic syndrome. Gestational diabetes mellitus (GDM) predicts type 2 diabetes and may be part of this syndrome. To examine the association of inflammatory markers with GDM, we investigated total sialic acid (TSA) in women with and without previ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Sriharan M,Reichelt AJ,Opperman ML,Duncan BB,Mengue SS,Crook MA,Schmidt MI

    更新日期:2002-08-01 00:00:00

  • Carotid atherosclerosis and serum lipoprotein(a) concentrations in patients with NIDDM.

    abstract:OBJECTIVE:To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS:We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT v...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Yamamoto M,Egusa G,Yamakido M

    更新日期:1997-05-01 00:00:00

  • Changes in BMI, duration of overweight and obesity, and glucose metabolism: 45 years of follow-up of a birth cohort.

    abstract:OBJECTIVE:Long-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity. RESEARCH DESIGN...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Power C,Thomas C

    更新日期:2011-09-01 00:00:00

  • Signs of beta-cell autoimmunity in nondiabetic schoolchildren: a comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate.

    abstract:OBJECTIVE:We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes. RESEARCH DESIGN AND METHODS:Serum samples were obtained from 3,652 nondiabetic schoolchildren in Finland ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Kondrashova A,Viskari H,Kulmala P,Romanov A,Ilonen J,Hyöty H,Knip M

    更新日期:2007-01-01 00:00:00

  • A meta-analysis of the association between childhood type 1 diabetes and atopic disease.

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    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Cardwell CR,Shields MD,Carson DJ,Patterson CC

    更新日期:2003-09-01 00:00:00