Exploratory trial of intranasal administration of glucagon-like peptide-1 in Japanese patients with type 2 diabetes.

abstract：OBJECTIVE:To examine the relationship between depressive symptoms and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:In 1984, 2,764 male employees of an electrical company in Japan completed a self-administered questionnaire including the Zung Self-Rating Depression Scale (SDS). They were followed for t...

journal_title：Diabetes care

authors： Kawakami N,Takatsuka N,Shimizu H,Ishibashi H

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:To compare diabetes care and outcomes among Haitians, African Americans, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We analyzed data from 715 Haitian, 1,472 African American, and 466 non-Hispanic white adults with diabetes using χ² testing and multiple logistic regression. RESULTS:Haitians had a h...

journal_title：Diabetes care

authors： Vimalananda VG,Rosenzweig JL,Cabral HJ,David MM,Lasser KE

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:This double-blind, placebo-controlled, randomized, multicenter, parallel-group study compared the efficacy, safety, and tolerability of Technosphere insulin with Technosphere powder as placebo in insulin-naive type 2 diabetic patients whose diabetes was suboptimally controlled with oral antidiabetic agents. ...

journal_title：Diabetes care

authors： Rosenstock J,Bergenstal R,Defronzo RA,Hirsch IB,Klonoff D,Boss AH,Kramer D,Petrucci R,Yu W,Levy B,0008 Study Group.

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of morta...

journal_title：Diabetes care

authors： Shah BR,Victor JC,Chiu M,Tu JV,Anand SS,Austin PC,Manuel DG,Hux JE

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...

journal_title：Diabetes care

authors： Hunt KJ,Baker NL,Cleary PA,Klein R,Virella G,Lopes-Virella MF,DCCT\/EDIC Group of Investigators.

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:We assessed the association between early increases in albumin excretion and cardiovascular (CV) and renal markers in a large cohort of young people with type 1 diabetes. RESEARCH DESIGN AND METHODS:As part of preliminary screening for a multicenter, randomized controlled trial of statins/ACE inhibitors, we ...

journal_title：Diabetes care

authors： Marcovecchio ML,Woodside J,Jones T,Daneman D,Neil A,Prevost T,Dalton RN,Deanfield J,Dunger DB,AdDIT Investigators.

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To determine whether intensive treatment and education strategies for type 2 diabetic patients with high-risk diabetic foot disease helps in preventing foot amputations. RESEARCH DESIGN AND METHODS:Participants included 4,872 consecutive type 2 diabetic patients (male-to-female ratio 3,422:1,450, mean (+/-SD...

journal_title：Diabetes care

authors： Viswanathan V,Madhavan S,Rajasekar S,Chamukuttan S,Ambady R

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To understand the interrelationship of coronary artery disease (CAD) risk factors including hyperlipidemia, hypertension, and glucose intolerance to prevent and better manage this disease. RESEARCH DESIGN AND METHODS:We performed a 100-g oral glucose tolerance test in 2,113 subjects, and we evaluated their p...

journal_title：Diabetes care

authors： Yamada N,Yoshinaga H,Sakurai N,Shimano H,Gotoda T,Ohashi Y,Yazaki Y,Kosaka K

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Various organizations have highlighted the need to examine whether abdominal obesity cut points are appropriate for identification of cardiovascular risk among ethnic minority adults, particularly Hispanic/Latino adults living in Western societies. This study aimed 1) to establish optimal definitions for abdo...

journal_title：Diabetes care

authors： Chirinos DA,Llabre MM,Goldberg R,Gellman M,Mendez A,Cai J,Sotres-Alvarez D,Daviglus M,Gallo LC,Schneiderman N

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Numerous studies have suggested a decreased risk of cancer in patients with diabetes on metformin. Because different comparison groups were used, the effect magnitude is difficult to estimate. Therefore, the objective of this study was to further analyze whether, and to what extent, use of metformin is associ...

journal_title：Diabetes care

authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

更新日期：2012-01-01 00:00:00

abstract：:Developments in fetal and placental nutrition have highlighted the interaction of the placenta and fetal liver for the exchange and metabolism of nutrients. Of particular importance is the exchange of serine and glycine and their interconversion within these two organs and the exchange of glutamine and glutamate. Plac...

journal_title：Diabetes care

authors： Battaglia FC,Thureen PJ

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:We evaluated whether the increasing number of genetic loci for coronary artery disease (CAD) identified in the general population could be used to predict the risk of major CAD events (MCE) among participants with type 2 diabetes at high cardiovascular risk. RESEARCH DESIGN AND METHODS:A weighted genetic ris...

journal_title：Diabetes care

authors： Morieri ML,Gao H,Pigeyre M,Shah HS,Sjaarda J,Mendonca C,Hastings T,Buranasupkajorn P,Motsinger-Reif AA,Rotroff DM,Sigal RJ,Marcovina SM,Kraft P,Buse JB,Wagner MJ,Gerstein HC,Mychaleckyj JC,Parè G,Doria A

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians....

journal_title：Diabetes care

authors： Dowse GK,Zimmet PZ,Gareeboo H,George K,Alberti MM,Tuomilehto J,Finch CF,Chitson P,Tulsidas H

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:The Hawaii IDDM Registry was created to determine the incidence rate of IDDM among children aged < 15 years of Oahu between 1980 and 1990. Because of the multiracial population living in Hawaii, it is an ideal state in which to study the effect of migration on IDDM incidence. RESEARCH DESIGN AND METHODS:Data...

journal_title：Diabetes care

authors： Patrick SL,Kadohiro JK,Waxman SH,Curb JD,Orchard TJ,Dorman JS,Kuller LH,LaPorte RE

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Insulin pump therapy (continuous subcutaneous insulin infusion [CSII]) and multiple daily injections (MDIs) with insulin glargine as basal insulin and mealtime insulin lispro have not been prospectively compared in people naïve to either regimen in a multicenter study. We aimed to help close that deficiency. ...

journal_title：Diabetes care

authors： Bolli GB,Kerr D,Thomas R,Torlone E,Sola-Gazagnes A,Vitacolonna E,Selam JL,Home PD

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...

journal_title：Diabetes care

authors： Succurro E,Andreozzi F,Sciacqua A,Hribal ML,Perticone F,Sesti G

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Adverse microbial exposures might contribute to diabetogenesis. We hypothesized that clinical periodontal disease (a manifestation of microbial exposures in dysbiotic biofilms) would be related to insulin resistance among diabetes-free participants. The roles of inflammatory mediation and effect modification ...

journal_title：Diabetes care

authors： Demmer RT,Squillaro A,Papapanou PN,Rosenbaum M,Friedewald WT,Jacobs DR Jr,Desvarieux M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To examine medical and mental health care expenditures for large numbers of individuals with diabetes enrolled in employment-sponsored insurance plans. RESEARCH DESIGN AND METHODS:Health insurance billing data for approximately 1.3 million individuals enrolled in health insurance plans sponsored by 862 large...

journal_title：Diabetes care

authors： Peele PB,Lave JR,Songer TJ

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Failure to meet goals for glycemic control in primary care settings may be due in part to lack of information critical to guide intensification of therapy. Our objective is to determine whether rapid-turnaround A1c availability would improve intensification of diabetes therapy and reduce A1c levels in patient...

journal_title：Diabetes care

authors： Miller CD,Barnes CS,Phillips LS,Ziemer DC,Gallina DL,Cook CB,Maryman SD,El-Kebbi IM

更新日期：2003-04-01 00:00:00

abstract：:Stress is a potential contributor to chronic hyperglycemia in diabetes. Stress has long been shown to have major effects on metabolic activity. Energy mobilization is a primary result of the fight or flight response. Stress stimulates the release of various hormones, which can result in elevated blood glucose levels. ...

journal_title：Diabetes care

authors： Surwit RS,Schneider MS,Feinglos MN

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:To explore the hypothesis that a relationship exists between free radical activity and abnormalities in hemostasis in NIDDM. RESEARCH DESIGN AND METHODS:The use of the total radical-trapping antioxidant parameter (TRAP) has very recently been proposed to explore the antioxidant property of a plasma and their...

journal_title：Diabetes care

authors： Ceriello A,Bortolotti N,Pirisi M,Crescentini A,Tonutti L,Motz E,Russo A,Giacomello R,Stel G,Taboga C

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Stress hyperglycemia increases the risk of mortality and poor outcomes in patients with acute myocardial infarction (AMI). We aimed to assess effects of intravenous nicorandil administered before reperfusion on AMI patients with stress hyperglycemia. RESEARCH DESIGN AND METHODS:This study consisted of 158 co...

journal_title：Diabetes care

authors： Ishii H,Ichimiya S,Kanashiro M,Amano T,Matsubara T,Murohara T

更新日期：2006-02-01 00:00:00

abstract：:This study describes the pharmacokinetics of three intermediate-acting insulin preparations, NPH porcine insulin, NPH human insulin (recombinant DNA), and "Depot-A" insulin, a mixture of 20% regular and 80% NPH human insulin from Eli Lilly and Company. Metabolic healthy normal weight volunteers were selected for the s...

journal_title：Diabetes care

authors： Bottermann P,Gyaram H,Wahl K,Ermler R,Lebender A

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:HbA1c is strongly related to the development of diabetes complications, but it is still controversial which HbA1c level to strive for in the treatment of type 1 diabetes. The aim of the current study was to evaluate HbA1c, followed from diagnosis, as a predictor of severe microvascular complications and to fo...

journal_title：Diabetes care

authors： Nordwall M,Abrahamsson M,Dhir M,Fredrikson M,Ludvigsson J,Arnqvist HJ

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To characterize metabolic effects of troglitazone in type 2 diabetic, obese, and lean subjects, and examine the effects of troglitazone 2-3 weeks after discontinuation. RESEARCH DESIGN AND METHODS:Nine type 2 diabetic, nine obese, and nine lean subjects underwent baseline metabolic studies including an 8-h m...

journal_title：Diabetes care

authors： Frias JP,Yu JG,Kruszynska YT,Olefsky JM

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the risk factors associated with the development of more advanced stages of kidney disease through large, long-term systematic analysis....

journal_title：Diabetes care

authors： Perkins BA,Bebu I,de Boer IH,Molitch M,Tamborlane W,Lorenzi G,Herman W,White NH,Pop-Busui R,Paterson AD,Orchard T,Cowie C,Lachin JM,Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Com

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To assess the effect of mixing the insulin analog lispro (Humalog) with NPH (Humulin I) before injection on lispro's fast, short action profile. RESEARCH DESIGN AND METHODS:A total of 12 healthy volunteers received subcutaneous abdominal injections of 0.1 U/kg regular insulin and 0.2 U/kg NPH insulin as foll...

journal_title：Diabetes care

authors： Joseph SE,Korzon-Burakowska A,Woodworth JR,Evans M,Hopkins D,Janes JM,Amiel SA

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Mortality from acute diabetes-related events is greatly raised in young adults with type 1 diabetes. Psychosocial and socioeconomic risk factors are examined for deaths from acute events separately from deaths due to other causes. RESEARCH DESIGN AND METHODS:This study had a nested case-control design. The c...

journal_title：Diabetes care

authors： Laing SP,Jones ME,Swerdlow AJ,Burden AC,Gatling W

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Reduced heart rate variability (HRV) and increased heart rate (HR) have been associated with cardiovascular mortality. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) increase HR, and studies have suggested that they may reduce HRV. We examined the effect of the GLP-1 RA liraglutide on HRV and diurnal v...

journal_title：Diabetes care

authors： Kumarathurai P,Anholm C,Larsen BS,Olsen RH,Madsbad S,Kristiansen O,Nielsen OW,Haugaard SB,Sajadieh A

更新日期：2017-01-01 00:00:00