Biologic and quality-of-life outcomes from the Mediterranean Lifestyle Program: a randomized clinical trial.

Abstract:

OBJECTIVE:Few multiple lifestyle behavior change programs have been designed to reduce the risk of coronary heart disease in postmenopausal women with type 2 diabetes. This study tested the effectiveness of the Mediterranean Lifestyle Program (MLP), a comprehensive lifestyle self-management program (Mediterranean low-saturated fat diet, stress management training, exercise, group support, and smoking cessation), in reducing cardiovascular risk factors in postmenopausal women with type 2 diabetes. RESEARCH DESIGN AND METHODS:Postmenopausal women with type 2 diabetes (n = 279) were randomized to either usual care (control) or treatment (MLP) conditions. MLP participants took part in an initial 3-day retreat, followed by 6 months of weekly meetings, to learn and practice program components. Biological end points were changes in HbA(1c), lipid profiles, BMI, blood pressure, plasma fatty acids, and flexibility. Impact on quality of life was assessed. RESULTS:Multivariate ANCOVAs revealed significantly greater improvements in the MLP condition compared with the usual care group on HbA(1c), BMI, plasma fatty acids, and quality of life at the 6-month follow-up. Patterns favoring intervention were seen in lipids, blood pressure, and flexibility but did not reach statistical significance. CONCLUSIONS:These results demonstrate that postmenopausal women with type 2 diabetes can make comprehensive lifestyle changes that may lead to clinically significant improvements in glycemic control, some coronary heart disease risk factors, and quality of life.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Toobert DJ,Glasgow RE,Strycker LA,Barrera M Jr,Radcliffe JL,Wander RC,Bagdade JD

doi

10.2337/diacare.26.8.2288

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

2288-93

issue

8

eissn

0149-5992

issn

1935-5548

journal_volume

26

pub_type

临床试验,杂志文章,随机对照试验
  • Diabetes and impaired fasting glycemia in the tribes of Khagrachari hill tracts of Bangladesh.

    abstract:OBJECTIVE:To determine the prevalence of type 2 diabetes and impaired fasting glycemia (IFG) in a tribal population of Bangladesh. RESEARCH DESIGN AND METHODS:A cluster sampling of 1,287 tribal subjects of age > or =20 years was investigated. They live in a hilly area of Khagrachari in the far northeast of Bangladesh....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.5.1054

    authors: Abu Sayeed M,Mahtab H,Akter Khanam P,Abul Ahsan K,Banu A,Rashid AN,Azad Khan AK

    更新日期:2004-05-01 00:00:00

  • Lifestyle Counseling and Long-term Clinical Outcomes in Patients With Diabetes.

    abstract:OBJECTIVE:To investigate the relationship between lifestyle counseling in primary care settings and clinical outcomes in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied hyperglycemic adults with diabetes treated at primary care practices between 2000 and 2014. We analyzed the relationshi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0629

    authors: Zhang H,Goldberg SI,Hosomura N,Shubina M,Simonson DC,Testa MA,Turchin A

    更新日期:2019-09-01 00:00:00

  • Limb- and Person-Level Risk Factors for Lower-Limb Amputation in the Prospective Seattle Diabetic Foot Study.

    abstract:OBJECTIVE:Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-l...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-2210

    authors: Boyko EJ,Seelig AD,Ahroni JH

    更新日期:2018-04-01 00:00:00

  • A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.

    abstract:OBJECTIVE:To investigate why, in spite of a vast variety of treatment agents, the alleviation of pain in patients with diabetic neuropathy is difficult. Previous studies have not used a treatment algorithm based on anatomic site and neuropathophysiological source of the neuropathic pain. RESEARCH DESIGN AND METHODS:A ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.16.8.1103

    authors: Pfeifer MA,Ross DR,Schrage JP,Gelber DA,Schumer MP,Crain GM,Markwell SJ,Jung S

    更新日期:1993-08-01 00:00:00

  • Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.

    abstract:OBJECTIVE:Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS:High-throughput ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc14-0850

    authors: Kemppainen KM,Ardissone AN,Davis-Richardson AG,Fagen JR,Gano KA,León-Novelo LG,Vehik K,Casella G,Simell O,Ziegler AG,Rewers MJ,Lernmark Å,Hagopian W,She JX,Krischer JP,Akolkar B,Schatz DA,Atkinson MA,Triplett EW,TED

    更新日期:2015-02-01 00:00:00

  • Hypogonadotropic Hypogonadism in Men With Diabesity.

    abstract::One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty. The gonadotropin concentrations in these males are inappropriately normal; thus, these pati...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc17-2510

    authors: Dhindsa S,Ghanim H,Batra M,Dandona P

    更新日期:2018-07-01 00:00:00

  • Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study.

    abstract:OBJECTIVE:Reports of amputations associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors have been inconsistent. We aimed to compare the risk of below-knee amputation with SGLT2 inhibitors versus dipeptidyl peptidase 4 (DPP-4) inhibitors among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This m...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0267

    authors: Yu OHY,Dell'Aniello S,Shah BR,Brunetti VC,Daigle JM,Fralick M,Douros A,Hu N,Alessi-Severini S,Fisher A,Bugden SC,Ronksley PE,Filion KB,Ernst P,Lix LM,Canadian Network for Observational Drug Effect Studies (CNODES) Investiga

    更新日期:2020-10-01 00:00:00

  • Long-term Effects of Disasters on Seniors With Diabetes: Evidence From Hurricanes Katrina and Rita.

    abstract:OBJECTIVE:To estimate the long-run mortality effects of Hurricanes Katrina and Rita on seniors with diabetes. RESEARCH DESIGN AND METHODS:We performed a retrospective cohort analysis of Medicare enrollment and claims data covering four states and ∼10 years. Affected individuals were identified by whether they lived in...

    journal_title:Diabetes care

    pub_type: 历史文章,杂志文章

    doi:10.2337/dc19-0567

    authors: Quast T,Andel R,Sadhu AR

    更新日期:2019-11-01 00:00:00

  • Improvements in patient-reported outcomes associated with an intervention to enhance quality of care for rural patients with type 2 diabetes: results of a controlled trial.

    abstract:OBJECTIVE:The aim of this study was to examine patient-reported outcomes in a controlled trial of a multifaceted provider-level intervention to improve quality of care for rural patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a before/after intervention study with concurrent controls in two rur...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.2337/diacare.27.6.1306

    authors: Maddigan SL,Majumdar SR,Guirguis LM,Lewanczuk RZ,Lee TK,Toth EL,Johnson JA

    更新日期:2004-06-01 00:00:00

  • Racial differences in the correlation between gonadal androgens and serum insulin levels.

    abstract:OBJECTIVE:We previously demonstrated a direct correlation between serum insulin levels and gonadal androgens (testosterone and androstenedione) in a group of obese hyperandrogenic predominantly black women. Subsequent work by others in predominantly white women showed conflicting results. To examine these potentially i...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.22.9.1524

    authors: Kitabchi AE,Imseis RE,Bush AJ,Williams-Cleaves B,Pourmotabbed G

    更新日期:1999-09-01 00:00:00

  • Prevalence of diabetes and impaired glucose tolerance in Funagata area, Japan.

    abstract:OBJECTIVE:To determine the prevalence of diabetes mellitus and IGT in the Funagata area of Japan. RESEARCH DESIGN AND METHODS:The total eligible subjects was 1163, all were > or = 45 yr of age, and 52 were known diabetic patients. Data collected included body height, weight, and answers to medical questionnaires. A 75...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.4.570

    authors: Sekikawa A,Tominaga M,Takahashi K,Eguchi H,Igarashi M,Ohnuma H,Sugiyama K,Manaka H,Sasaki H,Fukuyama H

    更新日期:1993-04-01 00:00:00

  • Why do low-fat high-carbohydrate diets accentuate postprandial lipemia in patients with NIDDM?

    abstract:OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.18.1.10

    authors: Chen YD,Coulston AM,Zhou MY,Hollenbeck CB,Reaven GM

    更新日期:1995-01-01 00:00:00

  • Using Indirect Measures to Identify Geographic Hot Spots of Poor Glycemic Control: Cross-sectional Comparisons With an A1C Registry.

    abstract:OBJECTIVE:Focusing health interventions in places with suboptimal glycemic control can help direct resources to neighborhoods with poor diabetes-related outcomes, but finding these areas can be difficult. Our objective was to use indirect measures versus a gold standard, population-based A1C registry to identify areas ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-0181

    authors: Lee DC,Jiang Q,Tabaei BP,Elbel B,Koziatek CA,Konty KJ,Wu WY

    更新日期:2018-07-01 00:00:00

  • Neuronal Food Reward Activity in Patients With Type 2 Diabetes With Improved Glycemic Control After Bariatric Surgery.

    abstract:OBJECTIVE:Obesity and type 2 diabetes mellitus (T2DM) are associated with altered food-related neuronal functions. Besides weight loss, substantial improvement of glucose metabolism in patients with T2DM can be achieved by bariatric surgery. We aimed to target the neuronal and behavioral correlates of improved glycemic...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-0094

    authors: Frank S,Heinze JM,Fritsche A,Linder K,von Feilitzsch M,Königsrainer A,Häring HU,Veit R,Preissl H

    更新日期:2016-08-01 00:00:00

  • Urinary estriols: are they of value in normoglycemic diabetic pregnancy?

    abstract::The purpose of the study was to assess the value of 24-h urinary estriols in the management of diabetic pregnancies. Twenty-seven pregnant diabetic patients (White's class B through R) received insulin dosages twice daily as a combination of NPH and regular insulin. Laboratory and home monitored blood glucose was main...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.3.316

    authors: Fern PE,Grunert GM,Lewis SB

    更新日期:1982-05-01 00:00:00

  • Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes.

    abstract:OBJECTIVE:Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the most common type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker could improve selection of subjects for genetic testing and increase diag...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-0422

    authors: Juszczak A,Pavić T,Vučković F,Bennett AJ,Shah N,Pape Medvidović E,Groves CJ,Šekerija M,Chandler K,Burrows C,Rojnić Putarek N,Vučić Lovrenčić M,Ćuća Knežević J,James TJ,Gloyn AL,Lauc G,McCarthy MI,Owen KR,Gornik O

    更新日期:2019-01-01 00:00:00

  • Dietary fat intake predicts 1-year change in body fat in adolescent girls with type 1 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to determine whether objectively measured physical activity and dietary macronutrient intake differentially predict body fat in adolescent girls with type 1 diabetes and control girls. RESEARCH DESIGN AND METHODS:This study comprised 23 girls (12-19 years) with type 1 diabetes a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2318

    authors: Särnblad S,Ekelund U,Aman J

    更新日期:2006-06-01 00:00:00

  • Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty.

    abstract:OBJECTIVE:Early puberty is associated with increased risk of subsequent cardiovascular disease. Low sex hormone-binding globulin (SHBG) levels are a feature of early puberty and of conditions associated with increased cardiovascular risk. The aim of the present study was to evaluate SHBG as a predictor of glucose metab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1618

    authors: Sørensen K,Aksglaede L,Munch-Andersen T,Aachmann-Andersen NJ,Petersen JH,Hilsted L,Helge JW,Juul A

    更新日期:2009-05-01 00:00:00

  • The effect of ruboxistaurin on nephropathy in type 2 diabetes.

    abstract:OBJECTIVE:Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS:A randomized, double-blind, placebo-controlled, multicent...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.28.11.2686

    authors: Tuttle KR,Bakris GL,Toto RD,McGill JB,Hu K,Anderson PW

    更新日期:2005-11-01 00:00:00

  • Central processing of gut pain in diabetic patients with gastrointestinal symptoms.

    abstract:OBJECTIVE:To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. RESEARCH DESIGN AND METHODS:The sensitivity to electrical esophageal and median nerve stimulations was assessed in 15 healthy volunteers and 14 type 1 diabetic patients with autonomi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0324

    authors: Frøkjaer JB,Søfteland E,Graversen C,Dimcevski G,Egsgaard LL,Arendt-Nielsen L,Drewes AM

    更新日期:2009-07-01 00:00:00

  • Declining rates of hospitalization for nontraumatic lower-extremity amputation in the diabetic population aged 40 years or older: U.S., 1988-2008.

    abstract:OBJECTIVE:To assess trends in rates of hospitalization for nontraumatic lower-extremity amputation (NLEA) in U.S. diabetic and nondiabetic populations and disparities in NLEA rates within the diabetic population. RESEARCH DESIGN AND METHODS:We calculated NLEA hospitalization rates, by diabetes status, among persons ag...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1360

    authors: Li Y,Burrows NR,Gregg EW,Albright A,Geiss LS

    更新日期:2012-02-01 00:00:00

  • Glycemic control in early IDDM. The Wisconsin Diabetes Registry.

    abstract:OBJECTIVE:A cohort (n = 277) was followed from diabetes diagnosis to evaluate longitudinal glycemic control, urinary C-peptide levels, and certain features of diabetes self-management. RESEARCH DESIGN AND METHODS:Unselected cases with IDDM, who were less than 30 yr of age, were identified at diagnosis from a 28-county...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.8.980

    authors: Allen C,Zaccaro DJ,Palta M,Klein R,Duck SC,D'Alessio DJ

    更新日期:1992-08-01 00:00:00

  • The effects of fenofibric acid alone and with statins on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia.

    abstract:OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dos...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-0357

    authors: Bays HE,Roth EM,McKenney JM,Kelly MT,Thakker KM,Setze CM,Obermeyer K,Sleep DJ

    更新日期:2010-09-01 00:00:00

  • Infant feeding in relation to islet autoimmunity and type 1 diabetes in genetically susceptible children: the MIDIA Study.

    abstract:OBJECTIVE:We aimed to study the association of breast-feeding duration and age at the introduction of solid foods with the risk of islet autoimmunity and type 1 diabetes in genetically susceptible children. RESEARCH DESIGN AND METHODS:Newborns were recruited from the Norwegian general population during 2001-2007. Afte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1130

    authors: Lund-Blix NA,Stene LC,Rasmussen T,Torjesen PA,Andersen LF,Rønningen KS

    更新日期:2015-02-01 00:00:00

  • Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime.

    abstract:OBJECTIVE:To establish differences in blood glucose between different regimens of optimized basal insulin substitution in type 1 diabetic patients given lispro insulin at meals, i.e., NPH injected four times a day versus glargine insulin once daily at dinner or at bedtime. RESEARCH DESIGN AND METHODS:A total of 51 pat...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.5.1490

    authors: Rossetti P,Pampanelli S,Fanelli C,Porcellati F,Costa E,Torlone E,Scionti L,Bolli GB

    更新日期:2003-05-01 00:00:00

  • Effect of intensive glycemic control on microalbuminuria in type 2 diabetes. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes Feasibility Trial Investigators.

    abstract:OBJECTIVE:Microalbuminuria can reflect the progress of microvascular complications and may be predictive of macrovascular disease in type 2 diabetes. The effect of intensive glycemic control on microalbuminuria in patients in the U.S. who have had type 2 diabetes for several years has not previously been evaluated. RE...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.10.1478

    authors: Levin SR,Coburn JW,Abraira C,Henderson WG,Colwell JA,Emanuele NV,Nuttall FQ,Sawin CT,Comstock JP,Silbert CK

    更新日期:2000-10-01 00:00:00

  • Epidemiology of Diabetes Interventions and Complications (EDIC). Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort.

    abstract:OBJECTIVE:The Diabetes Control and Complications Trial (DCCT) demonstrated the powerful impact of glycemic control on the early manifestations of microvascular complications. Contemporary prospective data on the evolution of macrovascular and late microvascular complications of type 1 diabetes are limited. The Epidemio...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.22.1.99

    authors:

    更新日期:1999-01-01 00:00:00

  • Risk factors predicting lower extremity amputations in patients with NIDDM.

    abstract:OBJECTIVE:To examine the predictors of lower extremity amputation in patients with NIDDM. RESEARCH DESIGN AND METHODS:At baseline, risk factors for amputation were determined in 1,044 NIDDM patients (571 men, 473 women) aged 45 to 64 years. These patients were followed up to 7 years with respect to amputation. RESULT...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.6.607

    authors: Lehto S,Rönnemaa T,Pyörälä K,Laakso M

    更新日期:1996-06-01 00:00:00

  • Impact of degree of obesity on surrogate estimates of insulin resistance.

    abstract:OBJECTIVE:To evaluate the role of adiposity in the relationship between specific and surrogate estimates of insulin-mediated glucose uptake (IMGU) in a large nondiabetic population. RESEARCH DESIGN AND METHODS:Healthy volunteers were classified by BMI into normal weight (<25.0 kg/m(2), n = 208), overweight (25.0-29.9 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.8.1998

    authors: Kim SH,Abbasi F,Reaven GM

    更新日期:2004-08-01 00:00:00

  • Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey.

    abstract:OBJECTIVE:To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity. RESEARCH DESIGN AND METHODS:We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988-...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.12.2813

    authors: Scragg R,Sowers M,Bell C,Third National Health and Nutrition Examination Survey.

    更新日期:2004-12-01 00:00:00