Abstract:
OBJECTIVE:Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS:High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland. RESULTS:Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location. CONCLUSIONS:The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Kemppainen KM,Ardissone AN,Davis-Richardson AG,Fagen JR,Gano KA,León-Novelo LG,Vehik K,Casella G,Simell O,Ziegler AG,Rewers MJ,Lernmark Å,Hagopian W,She JX,Krischer JP,Akolkar B,Schatz DA,Atkinson MA,Triplett EW,TEDdoi
10.2337/dc14-0850subject
Has Abstractpub_date
2015-02-01 00:00:00pages
329-32issue
2eissn
0149-5992issn
1935-5548pii
dc14-0850journal_volume
38pub_type
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