Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside.

abstract：OBJECTIVE:To evaluate the accuracy of the UK Prospective Diabetes Study Outcomes Model (UKPDS-OM) in predicting clinical outcomes during the UKPDS posttrial monitoring (PTM) period. RESEARCH DESIGN AND METHODS:At trial end in 1997, the 4,031 surviving UKPDS patients, of the 5,102 originally enrolled in the study, retu...

journal_title：Diabetes care

authors： Leal J,Hayes AJ,Gray AM,Holman RR,Clarke PM

更新日期：2013-06-01 00:00:00

abstract：:Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in l...

journal_title：Diabetes care

authors： Bedalov A,Balasubramanyam A

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Survival analysis was performed on a prospectively followed cohort of patients with cystic fibrosis (CF) to determine the impact of the development of diabetes on survival. RESEARCH DESIGN AND METHODS:Clinical data were retrieved for patients diagnosed with CF-related diabetes (CFRD) at the Minnesota CF Cent...

journal_title：Diabetes care

authors： Milla CE,Billings J,Moran A

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:The main purpose of this work was to study the possible differences in insulin secretion in a large group of type 2 diabetic patients in relation to diabetes duration, obesity, and the presence of secondary failure after treatment with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS:There were 147 nono...

journal_title：Diabetes care

authors： Prando R,Cheli V,Melga P,Giusti R,Ciuchi E,Odetti P

更新日期：1998-10-01 00:00:00

abstract：:Limited weight loss following jejunoileal bypass in 24 diabetic persons who were still distinctly overweight five to ten months after a mean weight decrease of 78 lbs. was accompanied by a return of normal fasting glucose and insulin levels, normal insulin responses, and a decrease in glucose intolerance. The glucose ...

journal_title：Diabetes care

authors： Ahmad U,Danowski TS,Nolan S,Stephan T,Sunder JH,Bahl VK

更新日期：1978-05-01 00:00:00

abstract：OBJECTIVE:To compare diabetes care and outcomes among Haitians, African Americans, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We analyzed data from 715 Haitian, 1,472 African American, and 466 non-Hispanic white adults with diabetes using χ² testing and multiple logistic regression. RESULTS:Haitians had a h...

journal_title：Diabetes care

authors： Vimalananda VG,Rosenzweig JL,Cabral HJ,David MM,Lasser KE

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:While there is growing evidence on the effectiveness of structured care for diabetic patients in trial settings, standard population level evaluations may misestimate intervention benefits due to patient selection. In order to account for potential biases in measuring intervention benefits, we tested the impa...

journal_title：Diabetes care

authors： Chevreul K,Brunn M,Cadier B,Nolte E,Durand-Zaleski I

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We a...

journal_title：Diabetes care

authors： Campbell-Thompson ML,Filipp SL,Grajo JR,Nambam B,Beegle R,Middlebrooks EH,Gurka MJ,Atkinson MA,Schatz DA,Haller MJ

更新日期：2019-02-01 00:00:00

abstract：:Cardiovascular outcome trials have provided evidence that sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment is associated with remarkably favorable cardiovascular outcomes. Here, we offer a novel hypothesis that may encompass many of these hypothetical mechanisms, i.e., the ability of SGLT2i to modify the tr...

journal_title：Diabetes care

authors： Avogaro A,Fadini GP,Del Prato S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To determine 1) whether participants in the Spanish Diabetes Self-Management Program (SDSMP), when compared at 6 months to randomized control subjects, would demonstrate improvements in health status, health behaviors, and self-efficacy; and 2) whether SDSMP participants receiving monthly automated telephone ...

journal_title：Diabetes care

authors： Lorig K,Ritter PL,Villa F,Piette JD

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To examine the hypothesis that hyperinsulinemia among relatives of NIDDM probands will increase the prevalence of DLPs, we measured insulin levels and examined the frequency of DLPs among NIDDM pedigree members. RESEARCH DESIGN AND METHODS:We performed 2-h 75-g OGTTs and measured lipid and insulin levels of ...

journal_title：Diabetes care

authors： Schumacher MC,Maxwell TM,Wu LL,Hunt SC,Williams RR,Elbein SC

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb+) in first-degree relatives of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Persistently islet autoAb+ siblings and offspring (n =...

journal_title：Diabetes care

authors： Gorus FK,Balti EV,Messaaoui A,Demeester S,Van Dalem A,Costa O,Dorchy H,Mathieu C,Van Gaal L,Keymeulen B,Pipeleers DG,Weets I,Belgian Diabetes Registry.

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate the rate of progression of nonalbuminuric chronic kidney disease (CKD) to end-stage kidney disease (ESKD) or death or major cardiovascular events (MACE) compared with albuminuric and nonalbuminuric phenotypes. RESEARCH DESIGN AND METHODS:We included 10,185 participants with type 2 dia...

journal_title：Diabetes care

authors： Buyadaa O,Magliano DJ,Salim A,Koye DN,Shaw JE

更新日期：2020-01-01 00:00:00

abstract：:Recent research on development of the implantable artificial pancreas for treatment of diabetes is reviewed, based on a Medline literature search that focused on glucose sensors, insulin pumps, and pump control systems. To achieve a closed feedback loop, a clinically applicable implantable artificial pancreas requires...

journal_title：Diabetes care

authors： Jaremko J,Rorstad O

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:To examine the effects of past and current night shift work and genetic type 2 diabetes vulnerability on type 2 diabetes odds. RESEARCH DESIGN AND METHODS:In the UK Biobank, we examined associations of current (N = 272,214) and lifetime (N = 70,480) night shift work exposure with type 2 diabetes risk (6,770 ...

journal_title：Diabetes care

authors： Vetter C,Dashti HS,Lane JM,Anderson SG,Schernhammer ES,Rutter MK,Saxena R,Scheer FAJL

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2)...

journal_title：Diabetes care

authors： Levy AP,Friedenberg P,Lotan R,Ouyang P,Tripputi M,Higginson L,Cobb FR,Tardif JC,Bittner V,Howard BV

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS:We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive life...

journal_title：Diabetes care

authors： Wing RR,Espeland MA,Clark JM,Hazuda HP,Knowler WC,Pownall HJ,Unick J,Wadden T,Wagenknecht L,Action for Health in Diabetes (Look AHEAD) Study Group.

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...

journal_title：Diabetes care

authors： Sharp LK,Lipsky MS

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:There is enough evidence that physical activity is an effective therapeutic tool in the management of type 2 diabetes. The present study was designed to validate a counseling strategy that could be used by physicians in their daily outpatient practice to promote the adoption and maintenance of physical activi...

journal_title：Diabetes care

authors： Di Loreto C,Fanelli C,Lucidi P,Murdolo G,De Cicco A,Parlanti N,Santeusanio F,Brunetti P,De Feo P

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Insulin resistance (IR) and the metabolic syndrome (MS) are associated with type 2 diabetes and adverse cardiovascular disease (CVD) risk factor profiles. Whether IR and MS predict CVD independently of diabetes and other CVD risk factors is not known. This study examines whether IR and/or presence of MS are i...

journal_title：Diabetes care

authors： Resnick HE,Jones K,Ruotolo G,Jain AK,Henderson J,Lu W,Howard BV,Strong Heart Study.

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:Left ventricular remodeling occurs immediately after MI, involving structural changes in noninfarcted segment. However, the residual left ventricular pump function in NIDDM patients after acute MI has not been clarified. The purpose of this study was to evaluate the difference in the process of left ventricul...

journal_title：Diabetes care

authors： Iwasaka T,Takahashi N,Nakamura S,Sugiura T,Tarumi N,Kimura Y,Okubo N,Taniguchi H,Matsui Y,Inada M

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To examine the significance of individual risk factors on the development of diabetes in subjects who underwent screening for diabetes. RESEARCH DESIGN AND METHODS:A total of 1,649 Chinese subjects underwent screening for diabetes. They were asymptomatic but had known risk factors for diabetes, including a p...

journal_title：Diabetes care

authors： Ko GT,Chan JC,Tsang LW,Yeung VT,Chow CC,Cockram CS

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was ...

journal_title：Diabetes care

authors： Bauman WA,Shaw S,Jayatilleke E,Spungen AM,Herbert V

更新日期：2000-09-01 00:00:00

abstract：:We studied the reliability of the Chemstrip system in the self-monitoring of blood glucose by diabetic patients. A total of 453 blood glucose values obtained by 38 diabetic patients using Chemstrip were compared with the glucose values of the same blood samples measured with a conventional laboratory method. We found ...

journal_title：Diabetes care

authors： Birch K,Hildebrandt P,Marshall MO,Sestoft L

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:This study assessed the ability to distinguish between type 1 diabetes-affected individuals and their unaffected relatives using HLA and single nucleotide polymorphism (SNP) genotypes. RESEARCH DESIGN AND METHODS:Eight models, ranging from only the high-risk DR3/DR4 genotype to all significantly associated H...

journal_title：Diabetes care

authors： Valdes AM,Varney MD,Erlich HA,Noble JA

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Glycemic control (HbA(1c) [A1C]) is strongly associated with microvascular disease in individuals with diabetes, but its relation to macrovascular disease and atherosclerosis is less clear. This study examines the relationship between A1C, carotid intima-media thickness (IMT), and traditional cardiovascular r...

journal_title：Diabetes care

authors： Selvin E,Coresh J,Golden SH,Boland LL,Brancati FL,Steffes MW,Atherosclerosis risk in communities study.

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia fo...

journal_title：Diabetes care

authors： Tran MP,Larsen JL,Duckworth WC,Ruby EI,Miller SA,Frisbie K,Taylor RJ,Stratta RJ

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Neonatal diabetes is a heterogeneous group of disorders with diabetes manifestation in the first 6 months of life. The most common etiology in permanent neonatal diabetes is mutations of the ATP-sensitive K(+) channel subunits; in transient neonatal diabetes, chromosome 6q24 abnormalities are the most common ...

journal_title：Diabetes care

authors： Staník J,Lethby M,Flanagan SE,Gasperíková D,Milosovicová B,Lever M,Bullman H,Zubcevic L,Hattersley AT,Ellard S,Ashcroft FM,Klimes I

更新日期：2008-09-01 00:00:00

abstract：:The goal of this study was to evaluate a program of resistance weight training on cardiovascular risk factors, blood glucose management, and overall strength in diabetic subjects. A randomized crossover design was performed on eight male type I (insulin-dependent) diabetic subjects (mean +/- SD age 31 +/- 3.5 yr, heig...

journal_title：Diabetes care

authors： Durak EP,Jovanovic-Peterson L,Peterson CM

更新日期：1990-10-01 00:00:00

abstract：:OBJECTIVE We tested whether average monthly glycemic burden (AMGB), a marker of hyperglycemia that is a function of the extent and duration that A1C exceeded 7%, indicated greater risk of cardiovascular disease (CVD) than traditional A1C measures. RESEARCH DESIGN AND METHODS Using a case-control design, we studied 2,4...

journal_title：Diabetes care

authors： Nichols GA,Rosales AG,Perrin NA,Fortmann SP

更新日期：2014-01-01 00:00:00