Abstract:
OBJECTIVE:Survival analysis was performed on a prospectively followed cohort of patients with cystic fibrosis (CF) to determine the impact of the development of diabetes on survival. RESEARCH DESIGN AND METHODS:Clinical data were retrieved for patients diagnosed with CF-related diabetes (CFRD) at the Minnesota CF Center in 1987-2002. Kaplan-Meier survival analysis was performed to estimate median survival. Data were analyzed by Cox regression to evaluate the influence of clinical characteristics at the time of CFRD diagnosis on mortality. RESULTS:Clinical information was reviewed from 1,081 CF patients. A total of 123 patients with CFRD with fasting hyperglycemia were identified (58 males). Median survival was 49.5 years for male subjects without diabetes, 47.4 years for male subjects with diabetes, 47.0 years for female subjects without diabetes, and 30.7 years for female subjects with diabetes. Only female sex and forced expiratory volume in 1 s at the time of CFRD diagnosis were significant predictors of the subsequent risk of death (P < 0.001). This strong association was not confounded by CFTR genotype, BMI, steroid use, respiratory pathogens, HbA1c, or pregnancy. CONCLUSIONS:Female subjects with CFRD have a remarkably poorer prognosis compared with all male subjects with CF and female subjects with CF but without diabetes. The etiology of this sex difference is not clear. We speculate it might involve the interaction of female hormones and diabetes on promotion of a proinflammatory state or that androgens might protect male subjects from the catabolic effects of insulin deficiency. Alternatively, the appearance of frank diabetes in female subjects with CF may simply be a marker for some other biological difference that is not immediately apparent.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Milla CE,Billings J,Moran Adoi
10.2337/diacare.28.9.2141subject
Has Abstractpub_date
2005-09-01 00:00:00pages
2141-4issue
9eissn
0149-5992issn
1935-5548pii
28/9/2141journal_volume
28pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS:We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive life...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-0509
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of treatment with the glucagon-like peptide 1 receptor agonist exenatide on weight loss and metabolic parameters in obese nondiabetic women. RESEARCH DESIGN AND METHODS:Forty-one obese women (aged 48 ± 11 years and BMI 33.1 ± 4.1 kg/m(2)) participated in a 35-week randomized, double...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0931
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Best-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best-practice dia...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1793
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Bariatric surgery may induce remission of type 2 diabetes in obese patients. However, estimates of remission rates reported in the literature range from 25 to 81%, contributing to the uncertainty patients and physicians both face as they assess treatment options. This analysis attempts to reconcile the seemin...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-0954
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-1304
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To compare albumin-to-creatinine ratio (ACR) and albumin concentration (ALB) for detection of microalbuminuria using precise data on CIs for sensitivity and specificity and to determine sex- and age-specific discriminator values for ACR. RESEARCH DESIGN AND METHODS:All consecutive patients investigated for t...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.2.307
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:To investigate whether microalbuminuria is associated with markers of the acute-phase response in NIDDM and whether there are ethnic differences in this association among the three main racial groups in Malaysia. RESEARCH DESIGN AND METHODS:NIDDM patients of Chinese, Indian, and Malay origin attending a diab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.3.385
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years. RESEARCH DESIGN AND METHODS:A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc06-1994
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To assess the level of serum lipoprotein(a) [Lp(a)] in nonobese and obese NIDDM subjects with android body distribution. RESEARCH DESIGN AND METHODS:Serum Lp(a) levels were measured in 30 long-standing NIDDM patients (duration of diabetes 12.5 +/- 3 years, mean +/- SD), with 15 of the patients being obese of...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.11.1693
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To study the relationship between exposure to antibiotic treatment and risk of subsequent myocardial infarction (MI) in patients with diabetes. RESEARCH DESIGN AND METHODS:A case-control design was used to assess the effect of previous antibiotic exposure in diabetes patients with acute, nonfatal or fatal MI...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.7.2100
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise. RESEARCH DESIGN AND METHODS:In a 24-week, randomized, double-blind, placebo-controlled, parallel-group study, 1,091 patients w...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc07-0627
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:Impaired awareness of hypoglycemia (IAH) and recurrent severe hypoglycemia (RSH) remain problematic for people with type 1 diabetes (T1D), despite major therapeutic advances. We explored beliefs around hypo- and hyperglycemia in adults with T1D with, and without, IAH and RSH. RESEARCH DESIGN AND METHODS:A cr...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc19-0002
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:To determine whether adults diagnosed with type 2 diabetes from age 18 to 44 years more aggressively develop clinical complications after diagnosis than adults diagnosed at >or=45 years of age. RESEARCH DESIGN AND METHODS:We compared outcomes among 7844 adults in a health maintenance organization who were ne...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.11.2999
更新日期:2003-11-01 00:00:00
abstract::In past studies on the psychological aspects of diabetes mellitus, symptoms of depression have been identified as the most common manifestation among diabetic patients. Other psychological manifestations have been anxiety, hypochondriasis, increased dependence and passivity, and poor self-image. Ten insulin-dependent ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.3.1.117
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:Conjugated linoleic acid (CLA) is a group of dietary fatty acids with antiobesity and antidiabetic effects in some animals. The trans10cis12 (t10c12) CLA isomer seems to cause these effects, including improved insulin sensitivity. Whether such isomer-specific effects occur in humans is unknown. The aim of thi...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.25.9.1516
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0630
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To determine contributions of trunk and extremity adiposity to cardiometabolic risk factors (blood pressure, fasting blood glucose, HDL cholesterol, and triglycerides) among white and African American adults. RESEARCH DESIGN AND METHODS:The sample consisted of 1,129 white women, 779 African American women, 1...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-2019
更新日期:2011-06-01 00:00:00
abstract::Use of pure porcine insulin versus partially purified insulin of bovine/porcine origin might be expected to have certain clinical benefits, e.g., a lower incidence of skin reactions, a lower insulin dosage, better diabetes regulation, and greater preservation of endogenous insulin secretion. To test this hypothesis, w...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.10.3.337
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:To identify hormonal, psychological, and demographic predictors of symptom detection and accuracy of blood glucose estimation during mild hypoglycemia in adolescents and young adults with type 1 diabetes. RESEARCH DESIGN AND METHODS:During an insulin-glucose clamp study, 53 adolescents and 19 young adults es...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.5.852
更新日期:2002-05-01 00:00:00
abstract::Specialists in childhood diabetes in North America were queried about the need for residential facilities for their patients with recurrent hospitalizations and school deficits due to family coping problems. Of 132 respondents, 115 indicated a need for 5-12% of their patients, a total of 530, close to the estimate of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.5.545
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVE:We previously demonstrated a direct correlation between serum insulin levels and gonadal androgens (testosterone and androstenedione) in a group of obese hyperandrogenic predominantly black women. Subsequent work by others in predominantly white women showed conflicting results. To examine these potentially i...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.9.1524
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:We sought to test the hypothesis that a fixed-dose combination of trandolapril/verapamil-SR (T/V) is superior to a fixed-dose combination of losartan/hydrochlorothiazide (L/H) on glucose tolerance in hypertensive patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS:A prospective, rando...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc06-1373
更新日期:2006-12-01 00:00:00
abstract::The scientific literature demonstrates that fat replacers have a reasonable certainty of no harm. Whether they help produce desired health outcomes, i.e., decreased risk of coronary heart disease and certain types of cancer related to excess fat intake, weight reduction, changes in lipid profile, improved glycemic con...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.19.11.1294
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:In the LixiLan-G trial, switching to iGlarLixi, a once-daily titratable fixed-ratio combination of insulin glargine 100 units/mL and the glucagon-like peptide 1 receptor agonist (GLP-1 RA) lixisenatide, improved glucose control in type 2 diabetes uncontrolled with GLP-1 RAs over 26 weeks versus continuing pri...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-2023
更新日期:2021-01-19 00:00:00
abstract:OBJECTIVE:We aimed to investigate the rate of progression of nonalbuminuric chronic kidney disease (CKD) to end-stage kidney disease (ESKD) or death or major cardiovascular events (MACE) compared with albuminuric and nonalbuminuric phenotypes. RESEARCH DESIGN AND METHODS:We included 10,185 participants with type 2 dia...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1438
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Because the bovine serum albumin residues 126-144 (ABBOS) have been reported to be responsible for the autoimmune reaction directed against pancreatic islet cells, it was our aim to study the potential survival of the ABBOS epitope during digestion in the gastrointestinal tract. RESEARCH DESIGN AND METHODS:E...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.875
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance. RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 4...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-1997
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the prevalence of both impaired fasting glucose (IFG) and diabetes between hepatitis C virus (HCV)-infected patients and patients with other liver diseases but anti-HCV-, taking into account the degree of liver damage. RESEARCH DESIGN AND METHODS:A total of 642 consecutiv...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.5.1171
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To examine the impact of Hurricane Katrina on the health of individuals with diabetes. RESEARCH DESIGN AND METHODS:This was an observational study in 1,795 adults with an A1C measurement 6 months before and 6-16 months after Hurricane Katrina in three health care systems: private (Tulane University Hospital ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0670
更新日期:2009-09-01 00:00:00
abstract::Intranasal glucagon can raise blood glucose levels in healthy subjects. The aims of this study were to 1) compare the hyperglycemic effect of intranasal and intramuscular glucagon in healthy subjects and type I (insulin-dependent) diabetes patients during euglycemic conditions and 2) test the efficacy of intranasal an...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.12.9.604
更新日期:1989-10-01 00:00:00