Anti-inflammatory and anticoagulant effects of pravastatin in patients with type 2 diabetes.

Abstract:

OBJECTIVE:Type 2 diabetes is associated with increased plasma concentrations of coagulation and inflammation markers. Different studies have shown that treatment with hydroxymethylglutaryl-CoA reductase inhibitors (statins) is associated with antithrombotic and anti-inflammatory effects in addition to a cholesterol-lowering effect. Our objective was to evaluate the effect of pravastatin (40 mg/day) on coagulation and inflammation markers in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:This was an open, randomized, crossover study designed with an 8-week intervention period. The study group was comprised of 50 patients with type 2 diabetes (median HbA(1c) 7.1%) and serum total cholesterol of 5-10 mmol/l. We evaluated plasma levels of fibrinogen, F1 + 2, D-dimer, soluble tissue factor (sTF), von Willebrand Factor antigen (vWFag), and C-reactive protein (CRP) in blood samples drawn after fasting on day 1 and after 8 and 16 weeks. RESULTS:Significant reductions of total cholesterol (-22%; P < 0.001), LDL cholesterol (-32%; P < 0.001), and triglycerides (-10%; P < 0.05) were achieved after 8 weeks of treatment with pravastatin. In addition, significant reductions of plasma levels of F1 + 2 (-4.4%; P < 0.05), vWFag (-5.3%; P < 0.05), and sTF (-3.4%; P < 0.05) were observed after treatment with pravastatin. Furthermore, plasma levels of CRP were also significantly reduced (-13%; P < 0.05). Levels of fibrinogen and D-dimer did not decrease after treatment with pravastatin. CONCLUSIONS:The results indicated that pravastatin reduces levels of coagulation and inflammation markers in type 2 diabetic patients. These antithrombotic and anti-inflammatory effects of treatment with statins could play a role in reducing cardiovascular complications in type 2 diabetic patients.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Sommeijer DW,MacGillavry MR,Meijers JC,Van Zanten AP,Reitsma PH,Ten Cate H

doi

10.2337/diacare.27.2.468

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

468-73

issue

2

eissn

0149-5992

issn

1935-5548

journal_volume

27

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    abstract::Regulation of gene transcription is a major action of insulin. Most of the greater than 20 examples of this effect involve the stimulation of transcription, but a few involve an inhibition. The inhibition of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene has been studied in detail. Most of this ef...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.13.3.327

    authors: O'Brien RM,Granner DK

    更新日期:1990-03-01 00:00:00

  • Apolipoprotein E polymorphism as a risk factor for vascular disease in diabetic patients.

    abstract:OBJECTIVE:To examine the prevalence of cardiovascular disease in diabetic patients as a function of apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:The apo E phenotypes and plasma lipid, lipoprotein, and apo levels were determined for 517 Italian diabetic patients. The prevalence of cardiovascular dis...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.4.504

    authors: Boemi M,Sirolla C,Amadio L,Fumelli P,Pometta D,James RW

    更新日期:1995-04-01 00:00:00

  • Diabetes and risk of Parkinson's disease: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Diabetes has been associated with chronic neurodegeneration. We performed a systematic review and meta-analysis to assess the relationship between pre-existing diabetes and Parkinson's disease (PD). RESEARCH DESIGN AND METHODS:Original articles in English published up to 10 May 2011 were searched for in elec...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审

    doi:10.2337/dc11-1584

    authors: Cereda E,Barichella M,Pedrolli C,Klersy C,Cassani E,Caccialanza R,Pezzoli G

    更新日期:2011-12-01 00:00:00

  • The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.

    abstract:OBJECTIVE:We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D. RESEARCH DESIGN AND METHODS:The PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the Trial...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-2787

    authors: Sosenko JM,Skyler JS,Beam CA,Boulware D,Mahon JL,Krischer JP,Greenbaum CJ,Rafkin LE,Matheson D,Herold KC,Palmer JP,Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups.

    更新日期:2015-05-01 00:00:00

  • Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S.

    abstract:OBJECTIVE:To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS:From U.S. electronic medical...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-2045

    authors: Dibato JE,Montvida O,Zaccardi F,Sargeant JA,Davies MJ,Khunti K,Paul SK

    更新日期:2021-01-01 00:00:00

  • Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.

    abstract:OBJECTIVE:To determine if baseline subgroups in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial can be identified for whom intensive compared with standard glycemia treatment had different effects on all-cause mortality. RESEARCH DESIGN AND METHODS:Exploratory post hoc intention-to-treat compariso...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc09-1471

    authors: Calles-Escandón J,Lovato LC,Simons-Morton DG,Kendall DM,Pop-Busui R,Cohen RM,Bonds DE,Fonseca VA,Ismail-Beigi F,Banerji MA,Failor A,Hamilton B

    更新日期:2010-04-01 00:00:00

  • Efficacy of feedback from quarterly laboratory comparison in maintaining quality of a hospital capillary blood glucose monitoring program.

    abstract:OBJECTIVE:A 1-year randomized prospective study was conducted to investigate the efficacy of feedback from split-sample testing as part of a capillary blood glucose quality assurance program. RESEARCH DESIGN AND METHODS:A total of 124 nurses were randomized to either group A (quarterly comparisons with feedback) or gr...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.2.168

    authors: Jones HE,Cleave B,Zinman B,Szalai JP,Nichol HL,Hoffman BR

    更新日期:1996-02-01 00:00:00

  • Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment.

    abstract::OBJECTIVE We previously reported that 2 years of costimulation modulation with abatacept slowed decline of β-cell function in recent-onset type 1 diabetes (T1D). Subsequently, abatacept was discontinued and subjects were followed to determine whether there was persistence of effect. RESEARCH DESIGN AND METHODS Of 112 ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc13-0604

    authors: Orban T,Bundy B,Becker DJ,Dimeglio LA,Gitelman SE,Goland R,Gottlieb PA,Greenbaum CJ,Marks JB,Monzavi R,Moran A,Peakman M,Raskin P,Russell WE,Schatz D,Wherrett DK,Wilson DM,Krischer JP,Skyler JS,Type 1 Diabetes Trial

    更新日期:2014-04-01 00:00:00

  • Age at onset and the risk of proliferative retinopathy in type 1 diabetes.

    abstract:OBJECTIVE:Age at onset of type 1 diabetes influences the risk of microvascular complications. However, the long-term risk of proliferative retinopathy within the wide spectrum of age at onset of type 1 diabetes is less well known. RESEARCH DESIGN AND METHODS:A sample of 1,117 consecutively recruited patients was drawn...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2278

    authors: Hietala K,Harjutsalo V,Forsblom C,Summanen P,Groop PH,FinnDiane Study Group.

    更新日期:2010-06-01 00:00:00

  • Can proopiomelanocortin methylation be used as an early predictor of metabolic syndrome?

    abstract:OBJECTIVE:The objectives of this study were to compare early predictive marker of the metabolic syndrome with proopiomelanocortin (POMC) methylation status and to determine the association among birth weight, ponderal index, and cord blood methylation status. RESEARCH DESIGN AND METHODS:We collected pregnancy outcome ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1012

    authors: Yoo JY,Lee S,Lee HA,Park H,Park YJ,Ha EH,Kim YJ

    更新日期:2014-01-01 00:00:00

  • Ocular Anti-VEGF therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy.

    abstract::Diabetic retinopathy is the leading cause of visual impairment and preventable blindness, and represents a significant socioeconomic cost for health care systems worldwide. Therefore, new approaches beyond current standards of diabetes care are needed. Based on the crucial pathogenic role of vascular endothelial growt...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc13-2002

    authors: Simó R,Sundstrom JM,Antonetti DA

    更新日期:2014-04-01 00:00:00

  • Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients.

    abstract:OBJECTIVE:Recipients of solid organ transplants have an increased risk of developing certain types of malignancies as compared with the general population. The majority of the literature has reported on neoplasms in kidney and heart transplant recipients. RESEARCH DESIGN AND METHODS:We describe 9 neoplasms occurring i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.3.272

    authors: Martinenghi S,Dell'Antonio G,Secchi A,Di Carlo V,Pozza G

    更新日期:1997-03-01 00:00:00

  • Concordance for type 1 diabetes in identical twins is affected by insulin genotype.

    abstract:OBJECTIVE:Monozygotic twins are usually discordant (only one twin affected) for type 1 diabetes. Discordance for disease between such twins implies a role for nongenetically determined factors but could also be influenced by a decreased load of diabetes susceptibility genes. The aim of this study was to determine wheth...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.5.838

    authors: Metcalfe KA,Hitman GA,Rowe RE,Hawa M,Huang X,Stewart T,Leslie RD

    更新日期:2001-05-01 00:00:00

  • Detection of symptoms by adolescents and young adults with type 1 diabetes during experimental induction of mild hypoglycemia: role of hormonal and psychological variables.

    abstract:OBJECTIVE:To identify hormonal, psychological, and demographic predictors of symptom detection and accuracy of blood glucose estimation during mild hypoglycemia in adolescents and young adults with type 1 diabetes. RESEARCH DESIGN AND METHODS:During an insulin-glucose clamp study, 53 adolescents and 19 young adults es...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.5.852

    authors: Ryan CM,Dulay D,Suprasongsin C,Becker DJ

    更新日期:2002-05-01 00:00:00

  • Risk Factors for Kidney Disease in Type 1 Diabetes.

    abstract:OBJECTIVE:In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the risk factors associated with the development of more advanced stages of kidney disease through large, long-term systematic analysis....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-2062

    authors: Perkins BA,Bebu I,de Boer IH,Molitch M,Tamborlane W,Lorenzi G,Herman W,White NH,Pop-Busui R,Paterson AD,Orchard T,Cowie C,Lachin JM,Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Com

    更新日期:2019-05-01 00:00:00

  • Temporal Trends in Incident Hospitalization for Diabetes-Related Foot Ulcer in Type 2 Diabetes: The Fremantle Diabetes Study.

    abstract:OBJECTIVE:To determine whether, reflecting trends in other chronic complications, incident hospitalization for diabetes-related foot ulcer (DFU) has declined over recent decades in type 2 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 2 diabetes from the community-based Fremantle Diabetes Study phases I ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1743

    authors: Hamilton EJ,Davis WA,Siru R,Baba M,Norman PE,Davis TME

    更新日期:2021-01-13 00:00:00

  • Incidence of type 1 diabetes in Lithuanians aged 0-39 years varies by the urban-rural setting, and the time change differs for men and women during 1991-2000.

    abstract:OBJECTIVE:Type 1 diabetes has been associated with factors related to welfare and social class. During the past decade, Lithuania has experienced a transition period, leading to dramatic changes in the socioeconomic structure of the society. RESEARCH DESIGN AND METHODS:Incidence in the group aged 0-39 years by urban-r...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.3.671

    authors: Pundziute-Lyckå A,Urbonaite B,Ostrauskas R,Zalinkevicius R,Dahlquist GG

    更新日期:2003-03-01 00:00:00

  • Optimal Blood Pressure Thresholds for Minimal Coronary Artery Disease Risk in Type 1 Diabetes.

    abstract:OBJECTIVE:We aimed to determine optimal blood pressure (BP) thresholds for minimizing coronary artery disease (CAD) risk in people with childhood-onset type 1 diabetes. RESEARCH DESIGN AND METHODS:The Pittsburgh Epidemiology of Diabetes Complications (EDC) Study participants without known CAD at baseline (n = 605) wer...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0480

    authors: Guo J,Brooks MM,Muldoon MF,Naimi AI,Orchard TJ,Costacou T

    更新日期:2019-09-01 00:00:00

  • Biphasic insulin aspart 30/70: pharmacokinetics and pharmacodynamics compared with once-daily biphasic human insulin and Basal-bolus therapy.

    abstract::OBJECTIVE Pharmacological profiles of biphasic insulin aspart 30/70 (BIAsp 30) once daily (OD), twice daily (b.i.d.), and three times daily (t.i.d.) were compared with other insulin regimens in two crossover glucose clamp studies of insulin-treated type 2 diabetic patients. RESEARCH DESIGNS AND METHODS Study 1 consist...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0097

    authors: Heise T,Heinemann L,Hövelmann U,Brauns B,Nosek L,Haahr HL,Olsen KJ

    更新日期:2009-08-01 00:00:00

  • The evaluation of a pocket computer as an aid to insulin dose determination by patients.

    abstract::A small and inexpensive computer was programmed to assist patients in making decisions regarding insulin delivery using constant subcutaneous infusion systems. Insulin dosage was based on gender, pre- and postprandial blood glucose, between-meal blood glucose, patient weight, time of day, and when appropriate, the car...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.2.172

    authors: Chanoch LH,Jovanovic L,Peterson CM

    更新日期:1985-03-01 00:00:00

  • Clinical predictors of disease progression and medication initiation in untreated patients with type 2 diabetes and A1C less than 7%.

    abstract:OBJECTIVE:Many patients with early diabetes remain untreated. Our objectives were to identify clinical predictors of 1) worsening glycemic control and 2) medical treatment initiation in response to worsening glycemic control among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:We identified 5,804 type 2 di...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1934

    authors: Pani LN,Nathan DM,Grant RW

    更新日期:2008-03-01 00:00:00

  • Prevalence and predictors of breast and cervical cancer screening among Spanish women with diabetes.

    abstract::OBJECTIVE To examine the use of mammography and Papanicolaou (Pap) smear among women with diabetes and to identify predictors of adherence to these tests. RESEARCH DESIGN AND METHODS We analyzed data of a nationally representative sample of Spanish women. Diabetes status was self-reported. Screenings were assessed ask...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0479

    authors: Jiménez-Garcia R,Hernandez-Barrera V,Carrasco-Garrido P,Gil A

    更新日期:2009-08-01 00:00:00

  • Immune Checkpoint Inhibitor-Associated Diabetes: A Single-Institution Experience.

    abstract:OBJECTIVE:To characterize immune checkpoint inhibitor-associated diabetes mellitus (ICI-DM) in a single-institution case series. RESEARCH DESIGN AND METHODS:Retrospective chart review of 18 patients with new-onset ICI-DM following anti-programmed cell death protein 1 (PD-1)/anti-programmed cell death protein ligand 1 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0609

    authors: Byun DJ,Braunstein R,Flynn J,Zheng J,Lefkowitz RA,Kanbour S,Girotra M

    更新日期:2020-12-01 00:00:00

  • Changes in Statin Use Among U.S. Adults With Diabetes: A Population-Based Analysis of NHANES 2011-2018.

    abstract:OBJECTIVE:To evaluate statin use in the U.S. before and after the 2015 American Diabetes Association position statement, which expanded statin therapy recommendations to include all adults 40-75 years old with diabetes. RESEARCH DESIGN AND METHODS:The National Health and Nutrition Examination Survey (NHANES) was used ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1481

    authors: Leino AD,Dorsch MP,Lester CA

    更新日期:2020-12-01 00:00:00

  • Association of symptoms of type 2 diabetic patients with severity of disease, obesity, and blood pressure.

    abstract:OBJECTIVE:The symptoms of 430 type 2 diabetic patients were determined by a self-administered questionnaire before entry into the U.K. Prospective Diabetes Study. RESEARCH DESIGN AND METHODS:Entry into the trial followed 2 months of dietary treatment for newly diagnosed patients with type 2 diabetes. Forty symptoms wi...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.21.1.111

    authors: Bulpitt CJ,Palmer AJ,Battersby C,Fletcher AE

    更新日期:1998-01-01 00:00:00

  • Preoperative A1C and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures.

    abstract:OBJECTIVE:To evaluate the relationship between preoperative A1C and clinical outcomes in individuals with diabetes mellitus undergoing noncardiac surgery. RESEARCH DESIGN AND METHODS:Data were obtained from the National Surgical Quality Improvement Program database and the Research Patient Data Registry of the Brigham...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1929

    authors: Underwood P,Askari R,Hurwitz S,Chamarthi B,Garg R

    更新日期:2014-01-01 00:00:00

  • 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2021.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practic...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc21-S009

    authors: American Diabetes Association.

    更新日期:2021-01-01 00:00:00

  • Leukocyte profiles differ between type 1 and type 2 diabetes and are associated with metabolic phenotypes: results from the German Diabetes Study (GDS).

    abstract:OBJECTIVE:Altered immune reactivity precedes and accompanies type 1 and type 2 diabetes. We hypothesized that the metabolic phenotype relates to the systemic cellular immune status. RESEARCH DESIGN AND METHODS:A total of 194 metabolically well-controlled patients with type 1 diabetes (n = 62, mean diabetes duration 1....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-0316

    authors: Menart-Houtermans B,Rütter R,Nowotny B,Rosenbauer J,Koliaki C,Kahl S,Simon MC,Szendroedi J,Schloot NC,Roden M,German Diabetes Study Group.

    更新日期:2014-08-01 00:00:00

  • Hypertriglyceridemia enhances monocyte binding to endothelial cells in NIDDM.

    abstract:OBJECTIVE:The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS:The binding of freshly isolated monocytes from patients with NIDDM, ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.10.1122

    authors: Hoogerbrugge N,Verkerk A,Jacobs ML,Postema PT,Jongkind JF

    更新日期:1996-10-01 00:00:00

  • Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum.

    abstract::In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0512

    authors: Raz I,Riddle MC,Rosenstock J,Buse JB,Inzucchi SE,Home PD,Del Prato S,Ferrannini E,Chan JC,Leiter LA,Leroith D,Defronzo R,Cefalu WT

    更新日期:2013-06-01 00:00:00