Hypertriglyceridemia enhances monocyte binding to endothelial cells in NIDDM.

Abstract:

OBJECTIVE:The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS:The binding of freshly isolated monocytes from patients with NIDDM, IDDM, and healthy control subjects to a monolayer of endothelial cells obtained from human umbilical vein was investigated. RESULTS:Endothelial adherence of monocytes from normolipidemic patients with IDDM (15.8 +/- 4.5%) or NIDDM (16.9 +/- 4.6%) was comparable to that of monocytes from a control population (15.3 +/- 3.5%). In patients with NIDDM with a serum triglyceride concentration > 2.5 mmol/l, the percentage of cells that adhere to endothelial cells in vitro was significantly increased (23.3 +/- 3.1%). Glycemic control did not correlate with monocyte adherence. The presence of symptomatic atherosclerotic disease, age, or sex was not associated with a change in monocyte binding in vitro. CONCLUSIONS:The results suggest that in NIDDM hypertriglyceridemia should be treated to reduce the high risk for atherosclerosis.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Hoogerbrugge N,Verkerk A,Jacobs ML,Postema PT,Jongkind JF

doi

10.2337/diacare.19.10.1122

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1122-5

issue

10

eissn

0149-5992

issn

1935-5548

journal_volume

19

pub_type

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