Abstract:
OBJECTIVE:The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS:The binding of freshly isolated monocytes from patients with NIDDM, IDDM, and healthy control subjects to a monolayer of endothelial cells obtained from human umbilical vein was investigated. RESULTS:Endothelial adherence of monocytes from normolipidemic patients with IDDM (15.8 +/- 4.5%) or NIDDM (16.9 +/- 4.6%) was comparable to that of monocytes from a control population (15.3 +/- 3.5%). In patients with NIDDM with a serum triglyceride concentration > 2.5 mmol/l, the percentage of cells that adhere to endothelial cells in vitro was significantly increased (23.3 +/- 3.1%). Glycemic control did not correlate with monocyte adherence. The presence of symptomatic atherosclerotic disease, age, or sex was not associated with a change in monocyte binding in vitro. CONCLUSIONS:The results suggest that in NIDDM hypertriglyceridemia should be treated to reduce the high risk for atherosclerosis.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Hoogerbrugge N,Verkerk A,Jacobs ML,Postema PT,Jongkind JFdoi
10.2337/diacare.19.10.1122subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1122-5issue
10eissn
0149-5992issn
1935-5548journal_volume
19pub_type
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