Abstract:
OBJECTIVE:This article evaluates prediction of HbA(1c) during an 18-month randomized trial of intensive therapy (IT) versus usual care (UC) for type 1 diabetes in 142 youth. RESEARCH DESIGN AND METHODS:Patients received a composite score for self-management competence (SMC) that combined standardized scores on baseline measures of diabetes knowledge, treatment adherence, and quality of health care interactions. They were categorized by tertiles split into low, moderate, and high SMC levels. RESULTS:IT yielded very similar mean HbA(1c) levels in all three SMC groups. However, in UC patients, HbA(1c) increased markedly for low-SMC youth but not for moderate- and high-SMC youth during the trial. Compared with the mean HbA(1c) of their UC counterparts, low-SMC patients realized greater glycemic benefit from IT than did the moderate- or high-SMC youth. Baseline SMC was more strongly correlated with HbA(1c) for UC than IT. CONCLUSIONS:All three SMC groups realized similar glycemic benefits from IT. The mean HbA(1c) levels of low-SMC patients in the UC group increased markedly over 18 months, whereas HbA(1c) levels of low-SMC patients in the IT group did not differ significantly from that of moderate- and high-SMC patients. Relative to their UC counterparts, low-SMC patients derived greater glycemic benefit from IT than did moderate- or high-SMC youth. SMC may be more critical to the success of UC than IT. Perhaps more importantly, patients should not be denied access to IT on the basis of limited competence in diabetes self-management.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Wysocki T,Harris MA,Wilkinson K,Sadler M,Mauras N,White NHdoi
10.2337/diacare.26.7.2043subject
Has Abstractpub_date
2003-07-01 00:00:00pages
2043-7issue
7eissn
0149-5992issn
1935-5548journal_volume
26pub_type
临床试验,杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To determine whether biomarkers of inflammation and endothelial dysfunction are associated with the development of kidney dysfunction and the time frame of their association. RESEARCH DESIGN AND METHODS:Biomarkers were measured at four time points during 28 years of treatment and follow-up in patients with t...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-0867
更新日期:2018-01-01 00:00:00
abstract::OBJECTIVE--To assess the relationship between family history and different types of obesity and change in obesity in a longitudinal population study. RESEARCH DESIGN AND METHODS--A longitudinal population study of 1462 randomly selected women (38-60 yr old) was conducted in Göteborg, Sweden, in 1968-69. The women were...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.11.1455
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:This study was designed to examine metabolic and hormonal effects of long-term exercise in healthy subjects and insulin-dependent (type I) diabetic patients. RESEARCH DESIGN AND METHODS:Two studies were performed. First, 16 healthy males (32 +/- 3 yr) were studied during a semitriathlon competition (2 km swi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.11.1736
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:Anti-programmed cell death-1 (anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD-1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations, including acute-onset type 1 diabetes. Acquired generalized lipodystrophy (AGL) is a rare disease, believ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-2535
更新日期:2019-10-01 00:00:00
abstract::The results of uncontrolled trials in immunomodulation of insulin-dependent diabetes mellitus (IDDM) led to randomized controlled trials in Canada and Europe. In the Canadian open study, the rate of clinical remissions (target control of glycemia maintained with less than or equal to 0.15 U.kg-1.day-1 insulin) was une...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:Studies showing that family communication and conflict resolution are critical to effective management of type 1 diabetes in adolescents have stimulated interest in evaluating psychological treatments targeting these processes. Previous trials have shown that Behavioral Family Systems Therapy (BFST) improved ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc06-1613
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:To create a simple prediction rule that could perform as well as the 2-h postchallenge plasma glucose (PCPG) test to predict those at risk for diabetes. We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort. RESEARCH DESIGN AND METHODS:A cross-se...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.2.404
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS:Using 1998-2014 National ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1259
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2671
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:No study has reported global disability burden estimates for individual diabetes-related lower-extremity complications (DRLECs). The Global Burden of Disease (GBD) study presents a robust opportunity to address this gap. RESEARCH DESIGN AND METHODS:GBD 2016 data, including prevalence and years lived with dis...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1614
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of the diabetic retinopathy (DR) screening with digital camera by endocrinologists with that by specialist and resident ophthalmologists in terms of sensitivity, specificity, and level of "loss of chance." RESEARCH DESIGN AND METHODS:In a cross-sectional study, 500 adult diabetic pati...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1373
更新日期:2011-03-01 00:00:00
abstract::Seventeen pregnant diabetic women participated in a special outpatient program during which they learned to self-monitor blood glucose (BG) and to vary insulin dosage on the basis of the results. The Ames Eyetone reflectance meter and the Boehringer Reflomat were used for BG analysis. BG was self-monitored at least tw...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.3.1.163
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:Studies comparing the incidence of blindness in persons with and without diabetes are scarce worldwide. In Germany, a decline in the incidence of blindness was found during the 1990s. The aim of this study was to analyze the recent time trend. RESEARCH DESIGN AND METHODS:Data were based on administrative fil...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-2031
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1481
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the possibility of replacing quantitative albumin excretion rate (AER) measurements with rapid screening tests for microalbuminuria. RESEARCH DESIGN AND METHODS:Dipstick-negative specimens from 363 consecutive insulin-dependent diabetes mellitus (IDDM) and 46 non-insulin-dependent diabetes mellit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.7.591
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:Depression is common in patients with diabetes and is associated with worse treatment outcomes. Its relationship to treatment adherence, however, has not been systematically reviewed. We used meta-analysis to examine the relationship between depression and treatment nonadherence in patients with type 1 and ty...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc08-1341
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.5.827
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To relate deterioration in kidney function to some potential cardiovascular risk factors in type II diabetic patients. RESEARCH DESIGN AND METHODS:Twenty-four normoalbuminuric and 13 microalbuminuric patients completed a 3.4-yr prospective observational study. Glomerular filtration rate, urinary albumin excr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.11.1427
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-2513
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Uncertainty remains regarding the predictive value of various glycemic measures as they relate to the risk of diabetes and its complications. Using the cutoffs recommended by the American Diabetes Association's 2010 criteria, we determined the associations of fasting plasma glucose (FPG), 2-h postload glucose...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc18-1390
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years. RESEARCH DESIGN AND METHODS:A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc06-1994
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this paper is to estimate the impact of diabetes on survival among patients with first acute myocardial infarction, using data from the World Health Organization (WHO) Monitoring Trends and Determinants of Cardiovascular Disease (MONICA) Project in Newcastle, New South Wales, Australia. RESEAR...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.704
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1321
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The incidence rate of childhood type 1 diabetes is thought to be increasing; however, Danish studies have not confirmed this. Using a national diabetes register initiated in 1996 and two previous regional incidence studies, we studied the age-specific incidence of type 1 diabetes over 30 years. Here, we descr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.12.2197
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:Epidemiological studies and randomized clinical trials have demonstrated in various populations that resting heart rate (RHR) was an independent predictor of cardiovascular (CV) risk and all-cause mortality. However, few data specifically evaluated the relationship between RHR and long-term CV and renal compl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2468
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS:Ten participants with type ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-2207
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:We aimed to explore whether frailty was associated with fracture risk and whether frailty could modify the propensity of type 2 diabetes toward increased risk of fractures. RESEARCH DESIGN AND METHODS:Data were from a prospective cohort study. Our primary outcome was time to the first incident clinical fragi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1965
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To assess the effects of empagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics. RESEARCH DESIGN AND METHODS:Aptamer-based proteomics was used to quantify 3,713 proteins in 144 paired plasma samples obtained from 72 participants across the ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0456
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To objectively evaluate adherence to timing and dosing of insulin by using Bluetooth pen caps and examine factors related to adherence. RESEARCH DESIGN AND METHODS:Bluetooth-enabled insulin pen caps were used in younger (ages 18-35 years) and older (ages ≥65 years) adults on two or more insulin injections pe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1631
更新日期:2019-06-01 00:00:00
abstract::OBJECTIVE--To determine and compare the abilities of various anthropometric measurements to predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indian men and women. RESEARCH DESIGN AND METHODS--A total of 290 male and 443 female Pima Indians were followed for up to 6 years for the devel...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.4.435
更新日期:1995-04-01 00:00:00