Abstract：
OBJECTIVE:To investigate the effect of normal aging on the protective responses against hypoglycemia, in view of the fact that type II diabetes is primarily a disease of aging, and its treatment is associated with risk of hypoglycemia with cognitive impairment. RESEARCH DESIGN AND METHODS:Plasma glucose was lowered stepwise from 5 to 2.4 mmol/l and restored by manipulation of an infusion of 20% glucose during 220-min intravenous infusion of 1.5 mU.kg-1.min-1 soluble insulin in 14 men; 7 were aged 60-70 years and the other 7 were 22-26 years. Changes in neurohumoral responses, subjective awareness, and choice reaction time were assessed. RESULTS:Hormonal responses were similar in the two groups, but symptoms began earlier in the younger men (at a plasma glucose of 3.6 +/- 0.1 vs. 3.0 +/- 0.2 mmol/l, P = 0.02) and were more intense (P = 0.03). Four-choice reaction time, a measure of psychomotor coordination, deteriorated earlier in the older men (at a plasma glucose of 3.0 +/- 0.1 vs. 2.6 +/- 0.1 mmol/l, P = 0.07) and to a greater degree. The difference between the glucose level for subjective awareness of hypoglycemia and the onset of cognitive dysfunction was lost in the older men (0.0 +/- 0.2 vs. 0.8 +/- 0.1 mmol/l, P < 0.007). CONCLUSIONS:Older men are prone to more severe cognitive impairment during hypoglycemia than younger men and are less likely to experience prior warning symptoms if blood glucose falls. This effect of normal aging may contribute to the risk of severe hypoglycemia in older diabetic patients treated with sulfonylureas and insulin.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Matyka K,Evans M,Lomas J,Cranston I,Macdonald I,Amiel SAdoi
10.2337/diacare.20.2.135subject
Has Abstractpub_date
1997-02-01 00:00:00pages
135-41issue
2eissn
0149-5992issn
1935-5548journal_volume
20pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract：OBJECTIVE:Prediabetes and type 2 diabetes mellitus (T2DM) are believed to be common and associated with a worse metabolic profile in patients with nonalcoholic fatty liver disease (NAFLD). However, no previous study has systematically screened this population. RESEARCH DESIGN AND METHODS:We studied the prevalence and ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc11-1849
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:The symptoms of 430 type 2 diabetic patients were determined by a self-administered questionnaire before entry into the U.K. Prospective Diabetes Study. RESEARCH DESIGN AND METHODS:Entry into the trial followed 2 months of dietary treatment for newly diagnosed patients with type 2 diabetes. Forty symptoms wi...
journal_title：Diabetes care
pub_type： 杂志文章,多中心研究
doi：10.2337/diacare.21.1.111
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:Many of the metabolic benefits of Roux-en-Y gastric bypass (RYGB) occur before weight loss. In this study we investigated the influence of caloric restriction on the improvements in the metabolic responses that occur within the 1st week after RYGB. RESEARCH METHODS AND DESIGN: A mixed meal was administered to...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc09-2107
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To assess associations between dietary intake and rates of change in insulin resistance and β-cell function in Hispanic women with prior gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Sixty-two nondiabetic Hispanic women with pregnancies complicated by GDM completed oral and intravenous glu...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc14-1433
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:High birth weight is a risk factor for neonatal complications. It is not known if the risk differs with body proportionality. The primary aim of this study was to determine the risk of adverse pregnancy outcome in relation to body proportionality in large-for-gestational-age (LGA) infants stratified by matern...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc13-0899
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:Previous studies have provided inconclusive results on the role of uric acid (UA) in risk prediction. Here we aimed to improve the power and precision of the predictive value of UA for the risk of decline in kidney function, cardiovascular events (CVEs), and mortality in patients with type 1 diabetes (T1D). ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc18-2173
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:Some children with type 1 diabetes may be at risk of cognitive impairments, but mechanisms of this effect have not been confirmed. The objective of this study was to determine whether severe hypoglycemia (SH) in children with type 1 diabetes is associated with cognitive decline over 18 months. RESEARCH DESIG...
journal_title：Diabetes care
pub_type： 杂志文章,多中心研究
doi：10.2337/diacare.26.4.1100
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in ty...
journal_title：Diabetes care
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2337/diacare.24.2.228
更新日期：2001-02-01 00:00:00
abstract：OBJECTIVE:To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic white (NHW) individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:We recently demonstrated in a small group of nonreferred, healthy, nond...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.27.5.1115
更新日期：2004-05-01 00:00:00
abstract：:Nutrient intake plays a significant role in the health outcomes of all pregnant women. In a pregnancy complicated by gestational diabetes mellitus (GDM), excellent glucose control is as foundational as appropriate weight gain and adequate nutrient intake. The controversies in GDM management include the following: how ...
journal_title：Diabetes care
pub_type： 杂志文章,评审
doi：10.2337/dc07-s214
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes. RESEARCH DESIGN AND METHODS:Serum samples were obtained from 3,652 nondiabetic schoolchildren in Finland ...
journal_title：Diabetes care
pub_type： 杂志文章,多中心研究
doi：10.2337/dc06-0711
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To determine whether intensive treatment and education strategies for type 2 diabetic patients with high-risk diabetic foot disease helps in preventing foot amputations. RESEARCH DESIGN AND METHODS:Participants included 4,872 consecutive type 2 diabetic patients (male-to-female ratio 3,422:1,450, mean (+/-SD...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.28.5.1019
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is lacking on individual cardiovascular outcomes and cause-specific mortality. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort analysis of 1,...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc17-1669
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To compare the prevalence of lumbar spondylolytic spondylolisthesis (LSS) in nondiabetic and diabetic subjects. RESEARCH DESIGN AND METHODS:A cross-sectional study of 1,147 randomly selected nondiabetic subjects and 892 non-insulin-dependent diabetes mellitus (NIDDM) patients, 45-64 years of age. LSS was dia...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.17.6.592
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:N-acetylglucosamine/galactosamine (GlycA) and sialic acid (GlycB) moieties of glycosylated serum proteins are nonspecific measures of inflammation, but conclusive data on their relationship with insulin resistance or insulin secretion are missing. Therefore, we aimed to examine the relation of GlycA, GlycB, a...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc16-1569
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:The risk of cardiovascular death before the age of 40 is 20-fold higher in patients with type 1 diabetes mellitus (T1DM). Endothelial progenitor cells (EPCs) predict cardiovascular morbidity and mortality in patients without diabetes. We hypothesized that EPCs are modified in children with T1DM and are relate...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc12-1206
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:Diabetes has held steady as the seventh leading cause of death in the U.S. since 2006. While aggregated data provide insights into how the country as a whole, or even as states, is faring with respect to diabetes mortality, disaggregation provides data that may facilitate targeted interventions and community ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc13-0988
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To explore the relationship between the genetic polymorphisms of PPARgamma (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARgamma would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc09-0717
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To estimate the prevalence of female sexual dysfunction (FSD) in diabetic and nondiabetic Jordanian women. RESEARCH DESIGN AND METHODS:Data were collected from 1,137 married women using the Arabic translation of the Female Sexual Function Index questionnaire. RESULTS:Prevalence of sexual dysfunction in diab...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc08-0081
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:Longitudinal changes in GAD antibody (Ab) and ICA512/IA-2 (ICA512) Ab were examined in relation to age at the onset of diabetes and autoimmunity against the thyroid gland. RESEARCH DESIGN AND METHODS:GADAb, ICA512Ab, and antithyroid autoantibody were examined at onset in 40 juvenile-onset IDDM patients (17 m...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.21.1.49
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:To determine the proportion of adults with diabetes in the U.S. who have received diabetes patient education and to assess factors that determine whether patients receive this education. RESEARCH DESIGN AND METHODS:A questionnaire on diabetes was administered to a representative sample of 2,405 diabetic indi...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.17.8.852
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:Improved appetite control, possibly mediated by exaggerated gut peptide responses to eating, may contribute to weight loss after Roux-en-Y gastric bypass (RYGB). This study compared brain responses to food ingestion between post-RYGB (RYGB), normal weight (NW), and obese (Ob) unoperated subjects and explored ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc15-2721
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:To describe the extent to which hyperglycemia, hypertension, and dyslipidemia are currently detected, treated, and controlled in U.S. veterans with diabetes with and without ischemic heart disease (IHD). RESEARCH DESIGN AND METHODS:A cohort of 3,769 veterans who self-reported diabetes and who received all he...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.27.suppl_2.b33
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:To determine whether elderly individuals with type 2 diabetes or impaired glucose tolerance are at increased risk for cognitive impairment compared with individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:Elderly Hispanic individuals (n = 414) and non-Hispanic white individuals (n = 469) a...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.24.9.1567
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between the insertion (I)/deletion (D) polymorphism of the ACE gene and arterial distensibility in patients with type 2 diabetes and healthy control subjects. RESEARCH DESIGN AND METHODS:Aortic and carotid arterial distensibility were evaluated by measuring aortic pulse-wave veloci...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/diacare.22.11.1858
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...
journal_title：Diabetes care
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2337/diacare.23.9.1343
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:We assessed whether type 2 diabetes is associated with renal cell carcinoma (RCC), independent of key potential confounders, in two large prospective cohorts with biennially updated covariate data. RESEARCH DESIGN AND METHODS:A total of 117,570 women from the Nurses' Health Study (NHS) and 48,866 men from th...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc17-2518
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:We sought to determine whether an oral disposition index (DI(O)) predicts the development of diabetes over a 10-year period. First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function. RESEARCH DESIGN ...
journal_title：Diabetes care
pub_type： 杂志文章
doi：10.2337/dc08-1478
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To investigate the influence of the insertion/deletion polymorphism of the ACE gene on the progression of early diabetic glomerulopathy in patients with and without antihypertensive treatment (AHT). RESEARCH DESIGN AND METHODS:There were 30 microalbuminuric patients with >5 years of type 1 diabetes who had r...
journal_title：Diabetes care
pub_type： 临床试验,杂志文章
doi：10.2337/diacare.23.4.544
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:To investigate the dose-response effects of pioglitazone on glycemic control, insulin sensitivity, and insulin secretion in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 58 diet-treated patients with type 2 diabetes (aged 54 +/- 1 years; 34 men and 24 women; BMI 31.5 +/- 0.6 kg/m(2)) ...
journal_title：Diabetes care
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2337/diacare.25.3.517
更新日期：2002-03-01 00:00:00
