Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66.

Abstract:

OBJECTIVE:Patients with diabetes have a higher case fatality rate in myocardial infarction (MI) or stroke than those without diabetes: that is, MI and stroke are more often fatal if diabetes is present. We investigated whether the risk of MI or stroke being fatal in type 2 diabetes can be estimated using information available around the time diabetes is diagnosed. RESEARCH DESIGN AND METHODS:Analyses were based on 674 cases of MI (351 fatal) that occurred in 597 of 5,102 U.K. Prospective Diabetes Study (UKPDS) patients for whom covariate data were available during a median follow-up of 7 years. Multivariate logistic regression was used to examine differences in risk factors, measured within 2 years of diagnosis of diabetes, between fatal and nonfatal MI. Similar analyses were performed for 234 strokes (48 fatal) that occurred in 199 patients. RESULTS:Patients with fatal MI had higher HbA(1c) than those with nonfatal MI (odds ratio 1.17 per 1% HbA(1c), P = 0.014). Patients with fatal stroke had higher HbA(1c) than those with nonfatal stroke (odds ratio 1.37 per 1% HbA(1c), P = 0.007). Other risk factors for MI case fatality included increased age, blood pressure, and urine albumin level. CONCLUSIONS:The risk of MI or stroke being fatal in type 2 diabetes is associated with risk factors, including HbA(1c), measured many years before onset of MI or stroke. Equations have been added to the UKPDS Risk Engine to estimate likely case fatality rates in MI and stroke.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Stevens RJ,Coleman RL,Adler AI,Stratton IM,Matthews DR,Holman RR

doi

10.2337/diacare.27.1.201

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

201-7

issue

1

eissn

0149-5992

issn

1935-5548

journal_volume

27

pub_type

杂志文章,多中心研究
  • Guidelines for premeal insulin dose reduction for postprandial exercise of different intensities and durations in type 1 diabetic subjects treated intensively with a basal-bolus insulin regimen (ultralente-lispro).

    abstract:OBJECTIVE:To evaluate and validate appropriate premeal insulin dose reductions for postprandial exercises of different intensities and durations to minimize the risk of exercise-induced hypoglycemia in type 1 diabetic subjects. RESEARCH DESIGN AND METHODS:Eight male type 1 diabetic patients on a basal-bolus insulin re...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.24.4.625

    authors: Rabasa-Lhoret R,Bourque J,Ducros F,Chiasson JL

    更新日期:2001-04-01 00:00:00

  • Plasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort.

    abstract:OBJECTIVE:Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS:At ba...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1199

    authors: Fernandez C,Surma MA,Klose C,Gerl MJ,Ottosson F,Ericson U,Oskolkov N,Ohro-Melander M,Simons K,Melander O

    更新日期:2020-02-01 00:00:00

  • Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

    abstract:OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/dc06-0564

    authors: Triplitt C,Glass L,Miyazaki Y,Wajcberg E,Gastaldelli A,De Filippis E,Cersosimo E,DeFronzo RA

    更新日期:2006-11-01 00:00:00

  • Need for residential treatment for children with diabetes mellitus.

    abstract::Specialists in childhood diabetes in North America were queried about the need for residential facilities for their patients with recurrent hospitalizations and school deficits due to family coping problems. Of 132 respondents, 115 indicated a need for 5-12% of their patients, a total of 530, close to the estimate of ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.5.545

    authors: Rosenbloom AL

    更新日期:1982-09-01 00:00:00

  • The prevalence of diabetes in a Swedish population of 280,411 inhabitants. A report from the Skaraborg Diabetes Registry.

    abstract:OBJECTIVE:To estimate the prevalence of known diabetes in a Swedish county (Skaraborg) and to evaluate capture-recapture methods for validation of the diabetes prevalence. RESEARCH DESIGN AND METHODS:Four sources were used to find known diabetic patients: 1) the Skaraborg Diabetes Registry (SDR), a case-finding invent...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.4.546

    authors: Berger B,Stenström G,Chang YF,Sundkvist G

    更新日期:1998-04-01 00:00:00

  • Heart rate variability in diabetes: relationship to age and duration of the disease.

    abstract::Heart rate variability (HRV) during deep breathing was studied with a neonatal heart monitor in 143 control subjects and 218 patients with diabetes (102 with IDDM and 116 with NIDDM). In the control group HRV decreased after age 20 by 4-5 beats per decade (from 29.7 +/- 5.8 beats at age 20-29 to 11.8 +/- 5.4 beats at ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.1.64

    authors: Masaoka S,Lev-Ran A,Hill LR,Vakil G,Hon EH

    更新日期:1985-01-01 00:00:00

  • American Diabetes Association's Fourth International Workshop-Conference on Gestational Diabetes Mellitus: summary and discussion. Therapeutic interventions.

    abstract::This review summarizes Session IV: Therapeutic Interventions of the Fourth International Gestational Diabetes Workshop and suggests intervention protocols based on the presentations at this meeting and the literature. The opinions of the six presenters and their interpretation of the review of the literature in their ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Jovanovic L

    更新日期:1998-08-01 00:00:00

  • Frailty and Risk of Fractures in Patients With Type 2 Diabetes.

    abstract:OBJECTIVE:We aimed to explore whether frailty was associated with fracture risk and whether frailty could modify the propensity of type 2 diabetes toward increased risk of fractures. RESEARCH DESIGN AND METHODS:Data were from a prospective cohort study. Our primary outcome was time to the first incident clinical fragi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1965

    authors: Li G,Prior JC,Leslie WD,Thabane L,Papaioannou A,Josse RG,Kaiser SM,Kovacs CS,Anastassiades T,Towheed T,Davison KS,Levine M,Goltzman D,Adachi JD,CaMos Research Group.

    更新日期:2019-04-01 00:00:00

  • Depression and diabetes treatment nonadherence: a meta-analysis.

    abstract:OBJECTIVE:Depression is common in patients with diabetes and is associated with worse treatment outcomes. Its relationship to treatment adherence, however, has not been systematically reviewed. We used meta-analysis to examine the relationship between depression and treatment nonadherence in patients with type 1 and ty...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审

    doi:10.2337/dc08-1341

    authors: Gonzalez JS,Peyrot M,McCarl LA,Collins EM,Serpa L,Mimiaga MJ,Safren SA

    更新日期:2008-12-01 00:00:00

  • Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients.

    abstract:OBJECTIVE:To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:The associations of serum A-FABP and E-FABP with markers of...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1333

    authors: Yeung DC,Xu A,Tso AW,Chow WS,Wat NM,Fong CH,Tam S,Sham PC,Lam KS

    更新日期:2009-01-01 00:00:00

  • Effect of drinking on adiponectin in healthy men and women: a randomized intervention study of water, ethanol, red wine, and beer with or without alcohol.

    abstract:OBJECTIVE:Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed. RESEARCH DESIGN AND METHODS:A total of 72 healthy individuals (22-56 years) were enrolle...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc08-1723

    authors: Imhof A,Plamper I,Maier S,Trischler G,Koenig W

    更新日期:2009-06-01 00:00:00

  • Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

    abstract::The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists considerable heterogeneity: disease onset spans the complete age range; genetic susceptibility is compl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0880

    authors: Battaglia M,Ahmed S,Anderson MS,Atkinson MA,Becker D,Bingley PJ,Bosi E,Brusko TM,DiMeglio LA,Evans-Molina C,Gitelman SE,Greenbaum CJ,Gottlieb PA,Herold KC,Hessner MJ,Knip M,Jacobsen L,Krischer JP,Long SA,Lundgren M

    更新日期:2020-01-01 00:00:00

  • The Impact of Glycated Hemoglobin (HbA1c) on Cardiovascular Disease Risk: A Mendelian Randomization Study Using UK Biobank.

    abstract:OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc18-0289

    authors: Au Yeung SL,Luo S,Schooling CM

    更新日期:2018-09-01 00:00:00

  • Conduction slowing in diabetic sensorimotor polyneuropathy.

    abstract:OBJECTIVE:Mild demyelination may contribute more to the pathophysiology of nerve fiber injury in diabetic sensorimotor polyneuropathy (DSP) than previously thought. We investigated the clinical and electrodiagnostic classifications of nerve injury in diabetic patients to detect evidence of conduction slowing in DSP. R...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0746

    authors: Dunnigan SK,Ebadi H,Breiner A,Katzberg HD,Lovblom LE,Perkins BA,Bril V

    更新日期:2013-11-01 00:00:00

  • Fat replacers: their use in foods and role in diabetes medical nutrition therapy.

    abstract::The scientific literature demonstrates that fat replacers have a reasonable certainty of no harm. Whether they help produce desired health outcomes, i.e., decreased risk of coronary heart disease and certain types of cancer related to excess fat intake, weight reduction, changes in lipid profile, improved glycemic con...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.19.11.1294

    authors: Warshaw H,Franz M,Powers MA,Wheeler M

    更新日期:1996-11-01 00:00:00

  • Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial.

    abstract:OBJECTIVE:Progressive nephropathy represents a substantial source of morbidity and mortality in type 1 diabetes. Increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk. Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0277

    authors: Lin J,Glynn RJ,Rifai N,Manson JE,Ridker PM,Nathan DM,Schaumberg DA

    更新日期:2008-12-01 00:00:00

  • A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study.

    abstract:OBJECTIVE:The aim of this study was to prospectively assess the relation between red meat intake and incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:Over an average of 8.8 years, we evaluated 37,309 participants in the Women's Health Study aged >/=45 years who were free of cardiovascular disease, cancer, and...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.9.2108

    authors: Song Y,Manson JE,Buring JE,Liu S

    更新日期:2004-09-01 00:00:00

  • Measuring diabetes self-care: a psychometric analysis of the Self-Care Inventory-Revised with adults.

    abstract:OBJECTIVE:To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS:We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometr...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.6.1346

    authors: Weinger K,Butler HA,Welch GW,La Greca AM

    更新日期:2005-06-01 00:00:00

  • Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic american indians: the Strong Heart Study.

    abstract:OBJECTIVE:Insulin resistance (IR) and the metabolic syndrome (MS) are associated with type 2 diabetes and adverse cardiovascular disease (CVD) risk factor profiles. Whether IR and MS predict CVD independently of diabetes and other CVD risk factors is not known. This study examines whether IR and/or presence of MS are i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.3.861

    authors: Resnick HE,Jones K,Ruotolo G,Jain AK,Henderson J,Lu W,Howard BV,Strong Heart Study.

    更新日期:2003-03-01 00:00:00

  • Validation of the WHO-5 Well-Being Index in adolescents with type 1 diabetes.

    abstract:OBJECTIVE:It is recommended that the psychological status of adolescents with diabetes be assessed periodically as part of ongoing care. The World Health Organization-Five Well-Being Index (WHO-5) is a short self-report instrument that appears suitable for this purpose. This study is the first to assess the reliability...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0447

    authors: de Wit M,Pouwer F,Gemke RJ,Delemarre-van de Waal HA,Snoek FJ

    更新日期:2007-08-01 00:00:00

  • Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.

    abstract:OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2302

    authors: Beulens JW,van der A DL,Grobbee DE,Sluijs I,Spijkerman AM,van der Schouw YT

    更新日期:2010-08-01 00:00:00

  • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes.

    abstract::There is increasing evidence that an ongoing cytokine-induced acute-phase response (sometimes called low-grade inflammation, but part of a widespread activation of the innate immune system) is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis....

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.27.3.813

    authors: Pickup JC

    更新日期:2004-03-01 00:00:00

  • Increased risk of childhood type 1 diabetes in children born after 1985.

    abstract:OBJECTIVE:The incidence rate of childhood type 1 diabetes is thought to be increasing; however, Danish studies have not confirmed this. Using a national diabetes register initiated in 1996 and two previous regional incidence studies, we studied the age-specific incidence of type 1 diabetes over 30 years. Here, we descr...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.12.2197

    authors: Svensson J,Carstensen B,Mølbak A,Christau B,Mortensen HB,Nerup J,Borch-Johnsen K

    更新日期:2002-12-01 00:00:00

  • Waist circumference and waist-to-hip ratio are related to gestational glucose tolerance.

    abstract:OBJECTIVE:To evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study investigated 1,113 consecutive women, > or = 20 years old, pregnant for approximately 21 to 28 weeks, wi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.4.509

    authors: Branchtein L,Schmidt MI,Mengue SS,Reichelt AJ,Matos MC,Duncan BB

    更新日期:1997-04-01 00:00:00

  • Abnormal glucose tolerance and hypertension.

    abstract::To quantify the association of abnormal glucose tolerance with hypertension and postural hypotension, 2480 men and women aged 50-89 yr from a defined population were evaluated by oral glucose tolerance and measurements of supine, seated, and standing blood pressure. In both sexes, adults with impaired glucose toleranc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.13.2.119

    authors: Reaven PD,Barrett-Connor EL,Browner DK

    更新日期:1990-02-01 00:00:00

  • Metformin and exercise in type 2 diabetes: examining treatment modality interactions.

    abstract:OBJECTIVE:To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS:Ten participants with type ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2207

    authors: Boulé NG,Robert C,Bell GJ,Johnson ST,Bell RC,Lewanczuk RZ,Gabr RQ,Brocks DR

    更新日期:2011-07-01 00:00:00

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.2.246

    authors: Levetan CS,Passaro M,Jablonski K,Kass M,Ratner RE

    更新日期:1998-02-01 00:00:00

  • Relationship Among Diabetes Distress, Decisional Conflict, Quality of Life, and Patient Perception of Chronic Illness Care in a Cohort of Patients With Type 2 Diabetes and Other Comorbidities.

    abstract:OBJECTIVE:The primary outcome is to evaluate the relationship between diabetes distress and decisional conflict regarding diabetes care in patients with diabetes and two or more comorbidities. Secondary outcomes include the relationships between diabetes distress and quality of life and patient perception of chronic il...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1256

    authors: Bruno BA,Choi D,Thorpe KE,Yu CH

    更新日期:2019-07-01 00:00:00

  • Effects of Vitamin D Supplementation on Insulin Sensitivity and Insulin Secretion in Subjects With Type 2 Diabetes and Vitamin D Deficiency: A Randomized Controlled Trial.

    abstract:OBJECTIVE:In observational studies, low vitamin D levels are associated with type 2 diabetes (T2D), impaired glucose metabolism, insulin sensitivity, and insulin secretion. We evaluated the efficacy of vitamin D supplementation on insulin sensitivity and insulin secretion in subjects with T2D and low vitamin D (25-hydr...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-2302

    authors: Gulseth HL,Wium C,Angel K,Eriksen EF,Birkeland KI

    更新日期:2017-07-01 00:00:00

  • Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes.

    abstract:OBJECTIVE:Diabetes eliminates the protective effect of female sex on the risk of coronary heart disease (CHD). We assessed sex differences in the treatment of CHD risk factors among patients with diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis included 3,849 patients with diabetes treated in five acad...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.28.3.514

    authors: Wexler DJ,Grant RW,Meigs JB,Nathan DM,Cagliero E

    更新日期:2005-03-01 00:00:00