Abstract：
OBJECTIVE:Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are available concerning this problem. RESEARCH DESIGN AND METHODS:Stomato-oncological screening was carried out on 200 diabetic patients in the medical departments; the control group included 280 adult dentistry outpatients. The lesions found were classified into three groups: inflammatory lesions, benign tumors, and precancerous lesions. A retrospective diabetes screening of 610 inpatients with histologically confirmed oral malignancies was also performed. The control group comprised 574 complaint- and tumor-free adults. Fasting blood glucose levels were determined in both groups, and the tumor location was registered in the cancer patients. RESULTS:Benign tumors were found in 14.5% and precancerous lesions in 8% of diabetic patients. In the control group these values were significantly lower, at 6.4 and 3.2%, respectively (P>0.01). Earlier Hungarian screening studies indicated similar frequency of these lesions in the general population. The proportion of oral cavity lesions was higher among diabetic patients compared with that of the control patients. In the oral cancer patient group, diabetes was present in 14.6% and an elevated blood glucose level in 9.7%. These values are significantly higher than those for the tumor-free control group (P<0.01). The gingival and labial tumor location was significantly more frequent among diabetic cancer patients than in the nondiabetic group (P<0.01). The combination of diabetes and smoking means a higher risk for oral precancerous lesions and malignancies. CONCLUSIONS:Diabetes may be a risk factor for oral premalignancies and tumors.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Ujpál M,Matos O,Bíbok G,Somogyi A,Szabó G,Suba Zdoi
10.2337/diacare.27.3.770subject
Has Abstractpub_date
2004-03-01 00:00:00pages
770-4issue
3eissn
0149-5992issn
1935-5548journal_volume
27pub_type
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