Metabolic consequences of hepatic steatosis in overweight and obese adolescents.

abstract：OBJECTIVE:Diabetic patients have a high prevalence of coronary artery disease (CAD), but timely diagnosis of CAD remains challenging. We assessed the ability of coronary computed tomography angiography (CCTA) to detect CAD in diabetic patients and to predict subsequent cardiac events. RESEARCH DESIGN AND METHODS:We an...

journal_title：Diabetes care

authors： Hadamitzky M,Hein F,Meyer T,Bischoff B,Martinoff S,Schömig A,Hausleiter J

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To evaluate effects of vildagliptin and metformin on blood pressure (BP) and heart rate (HR) responses to intraduodenal (ID) glucose in diet-controlled type 2 diabetes. RESEARCH DESIGN AND METHODS:Study A compared vildagliptin (50 mg) and placebo, given 60 min before a 120-min ID glucose infusion at 2 or 4 k...

journal_title：Diabetes care

authors： Wu T,Trahair LG,Little TJ,Bound MJ,Zhang X,Wu H,Sun Z,Horowitz M,Rayner CK,Jones KL

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：:A preliminary study was performed to estimate the effect of biosynthetic human insulin (BHI) produced by the Eli Lilly Company in comparison with purified pork insulin (PPI) from the same manufacturer. Immunologic studies were done using an intradermal skin test with both insulins and in vitro studies binding with ser...

journal_title：Diabetes care

authors： Federlin K,Laube H,Velcovsky HG

更新日期：1981-03-01 00:00:00

abstract：OBJECTIVE:To determine the role of growth hormone (GH) in the development of diabetic retinopathy. RESEARCH DESIGN AND METHODS:Medical records of 1,423 patients who had undergone insulin tolerance tests (1976-1991) at the Mayo Clinic were examined, and diabetic subjects were identified as either GH-deficient (GH incre...

journal_title：Diabetes care

authors： Alzaid AA,Dinneen SF,Melton LJ 3rd,Rizza RA

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:Patients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many of these features precede the development of diabetes. The aim of our study was to test for ...

journal_title：Diabetes care

authors： Stride A,Ellard S,Clark P,Shakespeare L,Salzmann M,Shepherd M,Hattersley AT

更新日期：2005-07-01 00:00:00

abstract：:In children with insulin-dependent diabetes mellitus (IDDM), deterioration in metabolic control frequently occurs during early adolescence. To prevent this predictable increase in blood glucose levels, we randomly assigned young adolescents with IDDM to an intervention based on problem solving with self-monitoring of ...

journal_title：Diabetes care

authors： Anderson BJ,Wolf FM,Burkhart MT,Cornell RG,Bacon GE

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:To study the association between selected risk factors and the subsequent incidence of type II diabetes over a 5-yr period. RESEARCH DESIGN AND METHODS:Between 1973 and 1976, a cohort of men from 22 clinical centers throughout the U.S. enrolled in the Usual Care group of the Multiple Risk Factor Intervention...

journal_title：Diabetes care

authors： Shaten BJ,Smith GD,Kuller LH,Neaton JD

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:We sought to test the hypothesis that a fixed-dose combination of trandolapril/verapamil-SR (T/V) is superior to a fixed-dose combination of losartan/hydrochlorothiazide (L/H) on glucose tolerance in hypertensive patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS:A prospective, rando...

journal_title：Diabetes care

authors： Bakris G,Molitch M,Hewkin A,Kipnes M,Sarafidis P,Fakouhi K,Bacher P,Sowers J,STAR Investigators.

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Studies showing that family communication and conflict resolution are critical to effective management of type 1 diabetes in adolescents have stimulated interest in evaluating psychological treatments targeting these processes. Previous trials have shown that Behavioral Family Systems Therapy (BFST) improved ...

journal_title：Diabetes care

authors： Wysocki T,Harris MA,Buckloh LM,Mertlich D,Lochrie AS,Mauras N,White NH

更新日期：2007-03-01 00:00:00

abstract：:Urinary albumin excretion rate (radial immunodiffusion), glomerular filtration rate (GFR) (single-shot 51Cr-EDTA technique), and arterial blood pressure (BP) were measured in 12 juvenile-onset, insulin-dependent diabetic patients with persistent proteinuria (greater than 0.5 g/day) due to diabetic nephropathy. Mean ag...

journal_title：Diabetes care

authors： Parving HH,Andersen AR,Smidt UM,Friisberg B,Svendsen PA

更新日期：1981-07-01 00:00:00

abstract：OBJECTIVE:Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for the development of type 2 diabetes in the mother and is responsible for morbidity in the child. To better identify women at risk of developing GDM we examined sociodemographic correlates and changes in the prevalence of GDM among...

journal_title：Diabetes care

authors： Anna V,van der Ploeg HP,Cheung NW,Huxley RR,Bauman AE

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Women exhibit exaggerated renal hemodynamic responses to hyperglycemia, which may promote kidney disease progression. Our aim was to determine if increased nitric oxide generation by l-arginine infusion would reverse this deleterious response to clamped hyperglycemia in women with type 1 diabetes mellitus. R...

journal_title：Diabetes care

authors： Cherney DZ,Scholey JW,Sochett EB

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare an in vivo test of whole-body glycolysis, the deuterated-glucose disposal test (2H-GDT), with insulin sensitivity measured by the euglycemic-hyperinsulinemic glucose clamp and the steady-state plasma glucose (SSPG) test. RESEARCH DESIGN AND METHODS:The 2H-GDT consists...

journal_title：Diabetes care

authors： Beysen C,Murphy EJ,McLaughlin T,Riiff T,Lamendola C,Turner HC,Awada M,Turner SM,Reaven G,Hellerstein MK

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:In 2010, the American Diabetes Association (ADA) added hemoglobin A1c (A1C) to the guidelines for diagnosing type 2 diabetes. However, existing models for predicting diabetes risk were developed prior to the widespread adoption of A1C. Thus, it remains unknown how well existing diabetes risk prediction models...

journal_title：Diabetes care

authors： Lacy ME,Wellenius GA,Carnethon MR,Loucks EB,Carson AP,Luo X,Kiefe CI,Gjelsvik A,Gunderson EP,Eaton CB,Wu WC

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To examine the magnitude and types of hospitalizations among persons with prediabetes, undiagnosed diabetes, and diagnosed diabetes. RESEARCH DESIGN AND METHODS:This study included 13,522 participants in the Atherosclerosis Risk in Communities (ARIC) study (mean age 57 years, 56% female, 24% black, 18% with ...

journal_title：Diabetes care

authors： Schneider AL,Kalyani RR,Golden S,Stearns SC,Wruck L,Yeh HC,Coresh J,Selvin E

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To assess the utility of a point-of-care (POC) capillary blood glucose measurement as compared with routine clinical parameters in predicting undiagnosed diabetes in a low-resource rural India setting. RESEARCH DESIGN AND METHODS:Nine hundred and ninety-four participants aged >30 years and stratified by age ...

journal_title：Diabetes care

authors： Ritchie GE,Kengne AP,Joshi R,Chow C,Neal B,Patel A,Zoungas S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that residential environment may influence health behaviors and outcomes. We assessed whether perception of neighborhood problems was associated with diabetes behaviors and outcomes. RESEARCH DESIGN AND METHODS:This cross-sectional analysis included 7,830 diabetic adults enrolled in Trans...

journal_title：Diabetes care

authors： Gary TL,Safford MM,Gerzoff RB,Ettner SL,Karter AJ,Beckles GL,Brown AF

更新日期：2008-02-01 00:00:00

abstract：:Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...

journal_title：Diabetes care

authors： Rosskamp RH,Park G

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians....

journal_title：Diabetes care

authors： Dowse GK,Zimmet PZ,Gareeboo H,George K,Alberti MM,Tuomilehto J,Finch CF,Chitson P,Tulsidas H

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:We have investigated age-period-cohort effects and spatial and temporal trends for the incidence of type 1 diabetes among 0- to 14-year-old children in Norway. RESEARCH DESIGN AND METHODS:We included children with the diagnosis of type 1 diabetes in Norway during 1973-1982 and 1989-2003. We studied age, cale...

journal_title：Diabetes care

authors： Aamodt G,Stene LC,Njølstad PR,Søvik O,Joner G,Norwegian Childhood Diabetes Study Group.

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. RESEARCH DESIGN AND METHODS:The sensitivity to electrical esophageal and median nerve stimulations was assessed in 15 healthy volunteers and 14 type 1 diabetic patients with autonomi...

journal_title：Diabetes care

authors： Frøkjaer JB,Søfteland E,Graversen C,Dimcevski G,Egsgaard LL,Arendt-Nielsen L,Drewes AM

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Although persistent hyperglycemia contributes greatly to the progression of diabetic micro- and macroangiopathy, microangiopathy progresses more rapidly than macroangiopathy in some type 2 diabetic patients, with the opposite being true in others. This study was conducted to identify factors responsible for s...

journal_title：Diabetes care

authors： Yamamoto M,Egusa G,Okubo M,Yamakido M

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity. RESEARCH DESIGN AND METHODS:We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988-...

journal_title：Diabetes care

authors： Scragg R,Sowers M,Bell C,Third National Health and Nutrition Examination Survey.

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy, safety, and compliance of a nonremovable fiberglass cast boot and off-loading shoes in the treatment of diabetic plantar ulcers. RESEARCH DESIGN AND METHODS:Patients (n = 93) with noninfected, nonischemic plantar ulcers were included in this prospective nonrandomized study. Treatment...

journal_title：Diabetes care

authors： Ha Van G,Siney H,Hartmann-Heurtier A,Jacqueminet S,Greau F,Grimaldi A

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To review the current knowledge about nonpharmacologic approaches in the prevention and early treatment of type 2 diabetes. RESEARCH DESIGN AND METHODS:This study reviewed the research reports dealing with nonpharmacologic interventions aimed at preventing type 2 diabetes with early lifestyle interventions. ...

journal_title：Diabetes care

authors： Tuomilehto J

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decl...

journal_title：Diabetes care

authors： Lajer M,Jorsal A,Tarnow L,Parving HH,Rossing P

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy and safety of prandial Technosphere inhaled insulin (TI), an inhaled insulin with a distinct time action profile, in insulin-naïve type 2 diabetes (T2D) inadequately controlled on oral antidiabetes agents (OADs). RESEARCH DESIGN AND METHODS:Subjects with T2D with HbA1c levels ≥7.5...

journal_title：Diabetes care

authors： Rosenstock J,Franco D,Korpachev V,Shumel B,Ma Y,Baughman R,Amin N,McGill JB,Affinity 2 Study Group.

更新日期：2015-12-01 00:00:00

abstract：:We evaluated the epidemiology of diabetic ketoacidosis in the period 1960-1979. In Frederiksborg County, Denmark, the incidence of ketoacidosis at the county hospital increased from 60 per 100,000 in the period 1943-1963 to 120 per 100,000 in the period 1960-1979. In the investigation period we found an increasing inc...

journal_title：Diabetes care

authors： Ellemann K,Soerensen JN,Pedersen L,Edsberg B,Andersen OO

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...

journal_title：Diabetes care

authors： Sharp LK,Lipsky MS

更新日期：1999-12-01 00:00:00