Biologic and immunologic in vivo and in vitro studies with biosynthetic human insulin.

abstract：:The complexity of the several pathogenic pathways that cause hypertension and vascular disease and the prolonged interval that appears to predate clinical morbidity have hindered inquiry into the association between GDM and vascular disorders. As a forme fruste of later type 2 diabetes, GDM-affected gravidas are ident...

journal_title：Diabetes care

authors： Carpenter MW

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The Diabetes Control and Complications Trial (DCCT) demonstrated the powerful impact of glycemic control on the early manifestations of microvascular complications. Contemporary prospective data on the evolution of macrovascular and late microvascular complications of type 1 diabetes are limited. The Epidemio...

journal_title：Diabetes care

authors：

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS par...

journal_title：Diabetes care

authors： Hamman RF,Wing RR,Edelstein SL,Lachin JM,Bray GA,Delahanty L,Hoskin M,Kriska AM,Mayer-Davis EJ,Pi-Sunyer X,Regensteiner J,Venditti B,Wylie-Rosett J

更新日期：2006-09-01 00:00:00

abstract：:Twenty-eight patients with type I diabetes mellitus, legally blind as a result of proliferative retinopathy, were recruited into a program designed to teach and evaluate tactile methods for self-monitoring of blood glucose (SMBG). Vision ranged from "blind" to "able to read large print." Techniques with wipe-off strip...

journal_title：Diabetes care

authors： Prior JC,Alojado NC,Hunt JA,Begg IS

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:It is still controversial whether sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) are equally effective in patients with diabetes. In these patients, multiple individual variables may be responsible for neointimal hyperplasia, thus making difficult the comparison of the two drug-eluting stent...

journal_title：Diabetes care

authors： Tomai F,Reimers B,De Luca L,Galassi AR,Gaspardone A,Ghini AS,Ferrero V,Favero L,Gioffrè G,Prati F,Tamburino C,Ribichini F

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To examine the predictors of lower extremity amputation in patients with NIDDM. RESEARCH DESIGN AND METHODS:At baseline, risk factors for amputation were determined in 1,044 NIDDM patients (571 men, 473 women) aged 45 to 64 years. These patients were followed up to 7 years with respect to amputation. RESULT...

journal_title：Diabetes care

authors： Lehto S,Rönnemaa T,Pyörälä K,Laakso M

更新日期：1996-06-01 00:00:00

abstract：:Twenty-nine diabetic renal failure patients suffered a psychosocial crisis at the time when chronic dialysis or renal transplantation was required. These patients could be classified into groups as to the impact of the crisis in terms of participation in life-support therapy. Group 1 consisted of potentially lethal me...

journal_title：Diabetes care

authors： D'Elia JA,Piening S,Kaldany A,Malarick C,Unger K,Ice S,Anderson RB,Miller DG,Lundin AP

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To characterize the relationship of subclinical and clinical eating disorders to HbA1c values in women with IDDM. RESEARCH DESIGN AND METHODS:Ninety women with IDDM (18-46 years of age) were recruited from diabetes clinics throughout Connecticut and Massachusetts. Subjects were categorized into one of three ...

journal_title：Diabetes care

authors： Affenito SG,Backstrand JR,Welch GW,Lammi-Keefe CJ,Rodriguez NR,Adams CH

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:Cytokine levels were measured in 19 healthy control subjects and 129 offspring of patients with type 2 diabetes (109 with normal...

journal_title：Diabetes care

authors： Ruotsalainen E,Salmenniemi U,Vauhkonen I,Pihlajamäki J,Punnonen K,Kainulainen S,Laakso M

更新日期：2006-12-01 00:00:00

abstract：:Cardiovascular outcome trials have provided evidence that sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment is associated with remarkably favorable cardiovascular outcomes. Here, we offer a novel hypothesis that may encompass many of these hypothetical mechanisms, i.e., the ability of SGLT2i to modify the tr...

journal_title：Diabetes care

authors： Avogaro A,Fadini GP,Del Prato S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Statins may reduce the risk of diabetic polyneuropathy (DPN) as a result of lipid-lowering and anti-inflammatory effects, but statins have also been associated with neurotoxicity. We examined whether statin therapy affects the risk of DPN. RESEARCH DESIGN AND METHODS:We identified all Danish patients with in...

journal_title：Diabetes care

authors： Kristensen FP,Christensen DH,Callaghan BC,Kahlert J,Knudsen ST,Sindrup SH,Feldman EL,Østergaard L,Andersen H,Jensen TS,Sørensen HT,Thomsen RW

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Although persistent hyperglycemia contributes greatly to the progression of diabetic micro- and macroangiopathy, microangiopathy progresses more rapidly than macroangiopathy in some type 2 diabetic patients, with the opposite being true in others. This study was conducted to identify factors responsible for s...

journal_title：Diabetes care

authors： Yamamoto M,Egusa G,Okubo M,Yamakido M

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS:We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometr...

journal_title：Diabetes care

authors： Weinger K,Butler HA,Welch GW,La Greca AM

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact. RESEARCH D...

journal_title：Diabetes care

authors： Ibsen DB,Steur M,Imamura F,Overvad K,Schulze MB,Bendinelli B,Guevara M,Agudo A,Amiano P,Aune D,Barricarte A,Ericson U,Fagherazzi G,Franks PW,Freisling H,Quiros JR,Grioni S,Heath AK,Huybrechts I,Katze V,Laouali N,

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure. RESEARCH DESIGN AND METHODS:We evaluated the association of diabetes and A1C with incident he...

journal_title：Diabetes care

authors： van Melle JP,Bot M,de Jonge P,de Boer RA,van Veldhuisen DJ,Whooley MA

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, al...

journal_title：Diabetes care

authors： Juntti-Berggren L,Pigon J,Karpe F,Hamsten A,Gutniak M,Vignati L,Efendic S

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To determine whether macronutrient intake differs by awareness of glycemic status among people with diabetes and prediabetes. RESEARCH DESIGN AND METHODS:We used 24-h dietary recall and other data from 3,725 nonpregnant adults with diabetes or prediabetes aged ≥20 years from the morning fasting sample of the...

journal_title：Diabetes care

authors： Bardenheier BH,Cogswell ME,Gregg EW,Williams DE,Zhang Z,Geiss LS

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

journal_title：Diabetes care

authors： Ozieh MN,Bishu KG,Dismuke CE,Egede LE

更新日期：2015-10-01 00:00:00

abstract：:In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...

journal_title：Diabetes care

authors： Nijs HG,Radder JK,Frölich M,Krans HM

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:To examine the association of renal function in diabetic patients with apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:Apo E genotypes, lipid and lipoprotein serum levels, creatinine clearance (CCr), and excretion of marker proteins were determined in German type 1 (IDDM; n = 162) and type 2...

journal_title：Diabetes care

authors： Werle E,Fiehn W,Hasslacher C

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Defects in insulin secretion and insulin action are the major abnormalities in the development of type 2 diabetes. In middle-aged subjects, elevated plasma proinsulin has been found to predict type 2 diabetes. Therefore, our aim was to study the longitudinal relationships between baseline determinations of in...

journal_title：Diabetes care

authors： Zethelius B,Hales CN,Lithell HO,Berne C

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between depressive symptoms and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:In 1984, 2,764 male employees of an electrical company in Japan completed a self-administered questionnaire including the Zung Self-Rating Depression Scale (SDS). They were followed for t...

journal_title：Diabetes care

authors： Kawakami N,Takatsuka N,Shimizu H,Ishibashi H

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between metformin use and anemia risk in type 2 diabetes, and the time-course for this, in a randomized controlled trial (RCT) and real-world population data. RESEARCH DESIGN AND METHODS:Anemia was defined as a hemoglobin measure of <11 g/dL. In the RCTs A Diabetes Outcome Progres...

journal_title：Diabetes care

authors： Donnelly LA,Dennis JM,Coleman RL,Sattar N,Hattersley AT,Holman RR,Pearson ER

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Newer medications offer more options for glycemic control in type 2 diabetes. However, they come at considerable costs. We undertook a health economic analysis to better understand the value of adding two newer medications (exenatide and sitagliptin) as second-line therapy to glycemic control strategies for p...

journal_title：Diabetes care

authors： Sinha A,Rajan M,Hoerger T,Pogach L

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Compare differences in health-related quality of life among blacks and whites to examine if race, diabetes, and visual impairment (VI) present a triple disadvantage in terms of quality-adjusted life expectancy. RESEARCH DESIGN AND METHODS:Data were analyzed from the 2000-2003 Medical Expenditure Panel Survey...

journal_title：Diabetes care

authors： McCollister KE,Zheng DD,Fernandez CA,Lee DJ,Lam BL,Arheart KL,Galor A,Ocasio M,Muennig P

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Intensive lifestyle intervention significantly reduced diabetes incidence among the participants in the Finnish Diabetes Prevention Study. We investigated whether and to what extent risk factors for type 2 diabetes and other baseline characteristics of the study participants modified the effectiveness of the ...

journal_title：Diabetes care

authors： Lindström J,Peltonen M,Eriksson JG,Aunola S,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Uusitupa M,Tuomilehto J,Finnish Diabetes Prevention Study (DPS) Group.

更新日期：2008-05-01 00:00:00

abstract：:Pancreatic beta cell responses were measured in obese and nonobese maturity-onset diabetes of the young (MODY) patients by estimating serum immunoreactive insulin (IRI) and C-peptide (CP) during oral glucose tolerance testing (OGTT). The serum CP responses were generally low in MODY patients and more pronounced in obe...

journal_title：Diabetes care

authors： Mohan V,Snehalatha C,Ramachandran A,Jayashree R,Viswanathan M

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Serine-threonine kinase STK11 catalyzes the AMP-activated protein kinase complex. We tested the hypothesis that a gene variant in STK11 contributes to variation in insulin sensitivity and metformin efficacy. RESEARCH DESIGN AND METHODS:We studied the effects of a single nucleotide polymorphism (SNP) (rs81116...

journal_title：Diabetes care

authors： López-Bermejo A,Díaz M,Morán E,de Zegher F,Ibáñez L

更新日期：2010-07-01 00:00:00

abstract：:Supine and standing heart rate and heart rate responses to deep breathing and standing up (the 30-to-15 ratio), indices of autonomic nervous function, were measured during each trimester and postpartum in 25 women with insulin-dependent diabetes and 10 nondiabetic women. The groups did not differ with respect to auton...

journal_title：Diabetes care

authors： Airaksinen KE,Salmela PI,Ikäheimo MJ,Kirkinen P,Linnaluoto MK,Takkunen JT

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:To compare diabetes care and outcomes among Haitians, African Americans, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We analyzed data from 715 Haitian, 1,472 African American, and 466 non-Hispanic white adults with diabetes using χ² testing and multiple logistic regression. RESULTS:Haitians had a h...

journal_title：Diabetes care

authors： Vimalananda VG,Rosenzweig JL,Cabral HJ,David MM,Lasser KE

更新日期：2011-01-01 00:00:00