Abstract:
OBJECTIVE:Diabetes and hypertension often co-occur and share risk factors. Hypertension is known to predict diabetes. However, hyperglycemia also may be independently associated with future development of hypertension. We investigated glycated hemoglobin (HbA(1c)) as a predictor of incident hypertension. RESEARCH DESIGN AND METHODS:We conducted a prospective analysis of 9,603 middle-aged participants in the Atherosclerosis Risk in Communities Study without hypertension at baseline. Using Cox proportional hazards models, we estimated the association between HbA(1c) at baseline and incident hypertension by two definitions 1) self-reported hypertension during a maximum of 18 years of follow-up and 2) measured blood pressure or hypertension medication use at clinic visits for a maximum of 9 years of follow-up. RESULTS:We observed 4,800 self-reported and 1,670 visit-based hypertension cases among those without diagnosed diabetes at baseline. Among those with diagnosed diabetes at baseline, we observed 377 self-reported and 119 visit-based hypertension cases. Higher baseline HbA(1c) was associated with an increased risk of hypertension in subjects with and without diabetes. Compared with nondiabetic adults with HbA(1c) <5.7%, HbA(1c) in the prediabetic range (5.7-6.4%) was independently associated with incident self-reported hypertension (hazard ratio 1.14 [95% CI 1.06-1.23]) and visit-detected hypertension (1.17 [1.03-1.33]). CONCLUSIONS:We observed that individuals with elevated HbA(1c), even without a prior diabetes diagnosis, are at increased risk of hypertension. HbA(1c) is a known predictor of incident heart disease and stroke. Our results suggest that the association of HbA(1c) with cardiovascular risk may be partially mediated by the development of hypertension.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Bower JK,Appel LJ,Matsushita K,Young JH,Alonso A,Brancati FL,Selvin Edoi
10.2337/dc11-2248subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1031-7issue
5eissn
0149-5992issn
1935-5548pii
dc11-2248journal_volume
35pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Type 2 diabetes is frequently complicated with atherogenic dyslipidemia. This study aimed to evaluate the efficacy and safety of pemafibrate (K-877) in patients with type 2 diabetes comorbid with hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Patients were randomly assigned to three groups and received pl...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc17-1589
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Little is known about the psychosocial challenges of adults living with type 1 diabetes or its impact on partner relationships. This qualitative study was undertaken to gain better understanding of these issues. RESEARCH DESIGN AND METHODS:Four focus groups were held, two with adult type 1 diabetic patients ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1718
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. RESEARCH DESIGN AND METHODS:We conducted a PubMed databa...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc11-0518
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Recurrence of plantar foot ulcers is a common and major problem in diabetes but not well understood. Foot biomechanics and patient behavior may be important. The aim was to identify risk factors for ulcer recurrence and to establish targets for ulcer prevention. RESEARCH DESIGN AND METHODS:As part of a footw...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-2470
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To examine medical and mental health care expenditures for large numbers of individuals with diabetes enrolled in employment-sponsored insurance plans. RESEARCH DESIGN AND METHODS:Health insurance billing data for approximately 1.3 million individuals enrolled in health insurance plans sponsored by 862 large...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.11.1964
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To examine the safety and efficacy of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, added on to pioglitazone in type 2 diabetes inadequately controlled on pioglitazone. RESEARCH DESIGN AND METHODS:Treatment-naive patients or those receiving metformin, sulfonylurea, or thiazolidinedione entered a...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc11-1693
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Women with preexisting (type 1 or type 2) diabetes experience an increased risk of serious adverse pregnancy outcomes. It is not known, however, how these risks change between the first and second pregnancy and whether there is an increased risk of recurrence. This study describes the absolute risks and recur...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1888
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Progressive nephropathy represents a substantial source of morbidity and mortality in type 1 diabetes. Increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk. Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-0277
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Mortality from acute diabetes-related events is greatly raised in young adults with type 1 diabetes. Psychosocial and socioeconomic risk factors are examined for deaths from acute events separately from deaths due to other causes. RESEARCH DESIGN AND METHODS:This study had a nested case-control design. The c...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.7.1618
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-l...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-2210
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:The primary outcome is to evaluate the relationship between diabetes distress and decisional conflict regarding diabetes care in patients with diabetes and two or more comorbidities. Secondary outcomes include the relationships between diabetes distress and quality of life and patient perception of chronic il...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1256
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Little is known about medial arterial calcification (MAC) other than its association with age, sex, diabetes, and diabetes complications. Familial aggregation of this disorder was studied to determine the importance of potential genetic factors and to assess whether such familial aggregation was independent o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.9.968
更新日期:1996-09-01 00:00:00
abstract::A 51-yr-old, nonobese, male patient presented with hyperglycemia and a recent 40-pound weight loss. Severe insulin resistance was documented in studies in which high amounts of insulin were infused using the Biostator GCIIS. Diabetic control was finally achieved with subcutaneous injections of 470 U of insulin per day...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.2.3.275
更新日期:1979-05-01 00:00:00
abstract::Biosynthetic human insulin (BHI) was compared with highly purified human pancreatic and pork insulin with regard to its ability to bind to erythrocytes of normal and insulin-dependent diabetic subjects (type I diabetes). The binding affinity or capacity of erythrocyte from both normal and diabetic subjects were compar...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.2.215
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:To examine central nervous system involvement as a possible complication of diabetes by performing a comprehensive neuropsychological evaluation of relatively young (age < 55 years) NIDDM patients and a group of control subjects. RESEARCH DESIGN AND METHODS:A cross-sectional comparative study of 28 patients,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.1.32
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of metabolic control in the progression of diabetic retinopathy during pregnancy. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort study of 155 diabetic women in the Diabetes in Early Pregnancy Study followed from the periconceptional period to 1 month postpartum. Fundus pho...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.18.5.631
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.9.1462
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:In patients with type 2 diabetes, microalbuminuria is associated with an increase in predominantly cardiovascular mortality. Considerable interindividual variability in the rate of progression of microalbuminuria exists. The prognostic significance of rate of progression of microalbuminuria with regard to car...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.12.2097
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of metformin on glycemic control, insulin resistance, and risk factors for cardiovascular disease in NIDDM subjects from two ethnic groups (Caucasian and Asian) with different risks of cardiovascular disease. RESEARCH DESIGN AND METHODS:A total of 27 subjects with NIDDM (17 Caucasi...
journal_title:Diabetes care
pub_type: 临床试验,评论,杂志文章,随机对照试验
doi:10.2337/diacare.16.4.621
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:We investigated the effect of glimepiride, a third-generation sulfonylurea hypoglycemic agent, on insulin resistance in elderly patients with type 2 diabetes, in connection with plasma adiponectin and 8-epi-prostagrandin F2alpha (8-epi-PGF2alpha), an oxidative stress marker. RESEARCH DESIGN AND METHODS:A tot...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.2.285
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare an in vivo test of whole-body glycolysis, the deuterated-glucose disposal test (2H-GDT), with insulin sensitivity measured by the euglycemic-hyperinsulinemic glucose clamp and the steady-state plasma glucose (SSPG) test. RESEARCH DESIGN AND METHODS:The 2H-GDT consists...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-1809
更新日期:2007-05-01 00:00:00
abstract::The effects of intravenous administration of potassium phosphate in the treatment of diabetic ketoacidosis were studied in nine children, ages 9 9/12 to 17 10/12 yr. During phosphate infusion (20--40 meq/L of fluid), all children maintained normal serum concentrations of phosphorus. Transient hypocalcemia occurred in ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.2.3.265
更新日期:1979-05-01 00:00:00
abstract:OBJECTIVE:It is believed that disruption of vulnerable atherosclerotic plaque and subsequent thrombus formation play critical roles in the pathogenesis of cerebral infarction. We simultaneously determined four relatively common genetic variants related to plaque rupture or subsequent local thrombus formation and evalua...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1518
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:The International Diabetes Federation (IDF) has proposed a new definition of the metabolic syndrome that emphasizes central adiposity as determined by ethnic group-specific thresholds of waist circumference. The objective of this study was to estimate the prevalence of this syndrome using the IDF definition a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.11.2745
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating beta-cell function after islet transplantation. For the current study, a composite beta-score was develop...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.2.343
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:This article evaluates prediction of HbA(1c) during an 18-month randomized trial of intensive therapy (IT) versus usual care (UC) for type 1 diabetes in 142 youth. RESEARCH DESIGN AND METHODS:Patients received a composite score for self-management competence (SMC) that combined standardized scores on baselin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.7.2043
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To validate fasting indices of insulin sensitivity and secretion in a diverse pediatric population against gold standard estimates from euglycemic and hyperglycemic clamps. RESEARCH DESIGN AND METHODS:A total of 31 children (mean BMI 25.1 +/- 4.9 kg/m(2), mean age 8.7 +/- 1.4 years, 15 girls and 16 boys, 12 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.11.2081
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the prevalence of diabetes in pregnancy (gestational diabetes mellitus [GDM] and NIDDM) and to identify risk factors in the development of GDM in a native population in northwestern Ontario, Canada. RESEARCH DESIGN AND METHODS:A retrospective analysis of 1,305 singl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.9.1422
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:It has been suggested that individuals with the condition known as metabolically healthy obesity (MHO) may not have the same increased risk for the development of metabolic abnormalities as their non-metabolically healthy counterparts. However, the validity of this concept has recently been challenged, since ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-0937
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The role of general practice and diabetes clinics in the management of diabetes is still a matter of debate. Methodological flaws in previous studies may have led to inaccurate conclusions when comparing the care provided in these different settings. We compared the care provided to type 2 diabetic patients a...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.27.2.398
更新日期:2004-02-01 00:00:00