当前位置： SCI文献检索 > DIABETES CARE期刊下所有文献 > Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance.

Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance.

Abstract：

OBJECTIVE:Visfatin is a novel adipokine that is predominantly secreted by visceral adipose tissue. Accumulation of visceral adipose tissue is also associated with iron metabolism. Despite the coincidence of visfatin expression in iron-rich tissues, no study has investigated the possible interaction of visfatin with parameters of iron metabolism. RESEARCH DESIGN AND METHODS:We evaluated insulin sensitivity and parameters of iron metabolism in 95 men with normal glucose tolerance (NGT) and 43 men with altered glucose tolerance. RESULTS:Men with newly diagnosed type 2 diabetes had significantly increased serum visfatin in parallel with increased serum prohepcidin and serum ferritin compared with the other groups. In all subjects as a whole, circulating visfatin was not found to be significantly linked to insulin sensitivity (r = 0.07, P = 0.4) but was significantly associated with serum prohepcidin concentration (r = 0.40, P < 0.0001). Obesity status and glucose tolerance status influenced the relationships among visfatin, insulin sensitivity, and parameters of iron metabolism. Among men with altered glucose tolerance, serum visfatin was strongly associated with serum prohepcidin (r = 0.61, P < 0.0001) and serum soluble transferrin receptor (sTfR) (r = -0.51, P < 0.0001). In nonobese subjects, sTfR (P = 0.02) and prohepcidin (P = 0.04) contributed independently to visfatin variance after controlling for age and BMI. When insulin sensitivity was added to the model, only the latter (P = 0.006) contributed to 17% of visfatin variance. In obese men, however, only sTfR (P = 0.04) contributed independently to visfatin variance in this latter model. CONCLUSIONS:Serum visfatin concentration is significantly associated with parameters of iron metabolism, especially in subjects with altered glucose tolerance.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Fernández-Real JM,Moreno JM,Chico B,López-Bermejo A,Ricart W

doi

10.2337/dc06-1581

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

616-21

issue

3

eissn

0149-5992

issn

1935-5548

pii

30/3/616

journal_volume

30

pub_type

杂志文章

相关文献

DIABETES CARE文献大全
  • Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients.

    abstract：OBJECTIVE:To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:The associations of serum A-FABP and E-FABP with markers of...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc08-1333

    authors： Yeung DC,Xu A,Tso AW,Chow WS,Wat NM,Fong CH,Tam S,Sham PC,Lam KS

    更新日期：2009-01-01 00:00:00

  • Impact of diabetes among revascularized patients in Japan and the U.S.

    abstract：OBJECTIVE:Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetes may differ according to ethnicit...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc11-1547

    authors： Kohsaka S,Goto M,Nagai T,Lee VV,Elayda M,Furukawa Y,Fukushima M,Komeda M,Sakata R,Ohsugi M,Fukuda K,Wilson JM,Kita T,Kimura T

    更新日期：2012-03-01 00:00:00

  • Determinants of fetal growth at different periods of pregnancies complicated by gestational diabetes mellitus or impaired glucose tolerance.

    abstract：OBJECTIVE:To determine maternal parameters with the strongest influence on fetal growth in different periods of pregnancies complicated by an abnormal glucose tolerance test (GTT). RESEARCH DESIGN AND METHODS:Retrospective study of 368 women with gestational diabetes mellitus (GDM; > or = 2 abnormal GTT values, n = 28...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.26.1.193

    authors： Schaefer-Graf UM,Kjos SL,Kilavuz O,Plagemann A,Brauer M,Dudenhausen JW,Vetter K

    更新日期：2003-01-01 00:00:00

  • Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes.

    abstract：OBJECTIVE:We investigated the efficacy and safety of the sodium glucose cotransporter 2 inhibitor, empagliflozin, added to multiple daily injections of insulin (MDI insulin) in obese patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS:Patients inadequately controlled on MDI insulin ± metformin (...

    journal_title：Diabetes care

    pub_type： 杂志文章,随机对照试验

    doi：10.2337/dc13-3055

    authors： Rosenstock J,Jelaska A,Frappin G,Salsali A,Kim G,Woerle HJ,Broedl UC,EMPA-REG MDI Trial Investigators.

    更新日期：2014-07-01 00:00:00

  • Hypertriglyceridemia enhances monocyte binding to endothelial cells in NIDDM.

    abstract：OBJECTIVE:The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS:The binding of freshly isolated monocytes from patients with NIDDM, ...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.19.10.1122

    authors： Hoogerbrugge N,Verkerk A,Jacobs ML,Postema PT,Jongkind JF

    更新日期：1996-10-01 00:00:00

  • Moderate intake of n-3 fatty acids for 2 months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Results of a controlled study.

    abstract：OBJECTIVE:To evaluate the effect of a moderate dose of fish oil on glycemic control and in vivo insulin action in type 2 diabetic men with elevated plasma triacylglycerols and to determine the effect of the same treatment on gene expression of GLUT4, lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in the a...

    journal_title：Diabetes care

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.2337/diacare.21.5.717

    authors： Luo J,Rizkalla SW,Vidal H,Oppert JM,Colas C,Boussairi A,Guerre-Millo M,Chapuis AS,Chevalier A,Durand G,Slama G

    更新日期：1998-05-01 00:00:00

  • A meta-analysis of the association between childhood type 1 diabetes and atopic disease.

    abstract：OBJECTIVE:To review the published literature and perform a meta-analysis summarizing the evidence in support of an inverse association between type 1 diabetes and the atopic disorders: asthma, eczema, and allergic rhinitis in children. RESEARCH DESIGN AND METHODS:MEDLINE, Web of Science, and PubMed were searched to id...

    journal_title：Diabetes care

    pub_type： 杂志文章,meta分析

    doi：10.2337/diacare.26.9.2568

    authors： Cardwell CR,Shields MD,Carson DJ,Patterson CC

    更新日期：2003-09-01 00:00:00

  • Elevated ambulatory blood pressure in microalbuminuric IDDM patients is inversely associated with renal plasma flow. A compensatory mechanism?

    abstract：OBJECTIVE:To evaluate the relationship between renal function, ambulatory blood pressure (AMBP), and glycemic control in microalbuminuric IDDM patients compared with normoalbuminuric patients. RESEARCH DESIGN AND METHODS:Nineteen male patients (age 33 +/- 6 years) with slight microalbuminuria (UAE 20-70 micrograms/min...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.20.3.429

    authors： Poulsen PL,Juhl B,Ebbehøj E,Klein F,Christiansen C,Mogensen CE

    更新日期：1997-03-01 00:00:00

  • Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults.

    abstract：OBJECTIVE:To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults. RESEARCH DESIGN AND METHODS:This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc09-1227

    authors： Carson AP,Reynolds K,Fonseca VA,Muntner P

    更新日期：2010-01-01 00:00:00

  • Changes in Screening Practices for Prediabetes and Diabetes Since the Recommendation for Hemoglobin A1c Testing.

    abstract：OBJECTIVE:Screening involves the presumptive identification of asymptomatic individuals at increased risk for unrecognized disease. We examined changes in screening practices for prediabetes and diabetes since January 2010, when HbA1c was first recommended as an option for screening and diagnosis. RESEARCH DESIGN AND ...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc17-1726

    authors： Evron JM,Herman WH,McEwen LN

    更新日期：2019-04-01 00:00:00

  • Early-morning hyperglycemia in diabetic individuals treated with continuous subcutaneous insulin infusion.

    abstract：:Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.6.2.135

    authors： Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

    更新日期：1983-03-01 00:00:00

  • Measurement of health status in diabetic patients. Diabetes impact measurement scales.

    abstract：OBJECTIVE:To develop an instrument to measure health status in adult insulin-dependent (type I) and non-insulin-dependent (type II) diabetic patients. RESEARCH DESIGN AND METHODS:Correlative study to examine psychometric properties of the questionnaire. Test-retest reliability, item-scale correlations, principal-compo...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.15.4.469

    authors： Hammond GS,Aoki TT

    更新日期：1992-04-01 00:00:00

  • High incidence of childhood-onset IDDM in Kuwait. Kuwait Study Group of Diabetes in Childhood.

    abstract：OBJECTIVE:To determine the incidence of insulin-dependent diabetes mellitus (IDDM) in children aged 0-14 years in Kuwait, as part of the World Health Organization Multinational Collaborative Study (DIAMOND), and to determine if the incidence rates have increased. RESEARCH DESIGN AND METHODS:All cases of IDDM diagnosed...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.18.7.923

    authors： Shaltout AA,Qabazard MA,Abdella NA,LaPorte RE,al Arouj M,Ben Nekhi A,Moussa MA,al Khawari MA

    更新日期：1995-07-01 00:00:00

  • Comparison of the effects of three insulinotropic drugs on plasma insulin levels after a standard meal.

    abstract：OBJECTIVE:To compare the effects of repaglinide, glipizide, and glibenclamide on insulin secretion and postprandial glucose after a single standard 500-kcal test meal. RESEARCH DESIGN AND METHODS:A total of 12 type 2 diabetic patients with early diabetes (mean HbA(1c) of 6.1%) and 12 matched control subjects were enro...

    journal_title：Diabetes care

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.2337/diacare.25.8.1271

    authors： Cozma LS,Luzio SD,Dunseath GJ,Langendorg KW,Pieber T,Owens DR

    更新日期：2002-08-01 00:00:00

  • The efficacy and safety of human insulin (Novo) in insulin-dependent diabetic patients.

    abstract：:Fifty-one insulin-dependent diabetic patients, 26 children and 25 adults, participated in an open uncontrolled study of the safety and efficacy of human insulin (Novo). The patients, who had previously been treated exclusively with porcine insulin, were followed in two outpatient clinics during a 3-mo study period. Du...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：

    authors： Lyngsøe J,Vestermark S

    更新日期：1983-03-01 00:00:00

  • Skeletal muscle morphology and exercise response in congenital generalized lipodystrophy.

    abstract：OBJECTIVE:Congenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth. We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morpho...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.23.10.1545

    authors： Garg A,Stray-Gundersen J,Parsons D,Bertocci LA

    更新日期：2000-10-01 00:00:00

  • Fatty acid composition of serum lipid fractions in type 2 diabetic patients with microalbuminuria.

    abstract：OBJECTIVE:To determine the fatty acid composition of serum phospholipid, triglyceride, and cholesterol ester fractions and to analyze the lipid profile of microalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A case-control study was conducted with 72 patients: 37 were normoalbuminuric (urinary albumi...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.26.3.613

    authors： Perassolo MS,Almeida JC,Prá RL,Mello VD,Maia AL,Moulin CC,Camargo JL,Zelmanovitz T,Azevedo MJ,Gross JL

    更新日期：2003-03-01 00:00:00

  • Outcomes of screening for diabetes in high-risk Hong Kong Chinese subjects.

    abstract：OBJECTIVE:To examine the significance of individual risk factors on the development of diabetes in subjects who underwent screening for diabetes. RESEARCH DESIGN AND METHODS:A total of 1,649 Chinese subjects underwent screening for diabetes. They were asymptomatic but had known risk factors for diabetes, including a p...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.23.9.1290

    authors： Ko GT,Chan JC,Tsang LW,Yeung VT,Chow CC,Cockram CS

    更新日期：2000-09-01 00:00:00

  • Prevalence and predictors of breast and cervical cancer screening among Spanish women with diabetes.

    abstract：:OBJECTIVE To examine the use of mammography and Papanicolaou (Pap) smear among women with diabetes and to identify predictors of adherence to these tests. RESEARCH DESIGN AND METHODS We analyzed data of a nationally representative sample of Spanish women. Diabetes status was self-reported. Screenings were assessed ask...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc09-0479

    authors： Jiménez-Garcia R,Hernandez-Barrera V,Carrasco-Garrido P,Gil A

    更新日期：2009-08-01 00:00:00

  • Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study.

    abstract：OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc12-2671

    authors： Hansen AL,Carstensen B,Helge JW,Johansen NB,Gram B,Christiansen JS,Brage S,Lauritzen T,Jørgensen ME,Aadahl M,Witte DR,ADDITION-Denmark Steering Committee.

    更新日期：2013-10-01 00:00:00

  • Age-adjusted diabetes mortality rates vary in local communities in a metropolitan area: racial and spatial disparities and correlates.

    abstract：OBJECTIVE:Diabetes has held steady as the seventh leading cause of death in the U.S. since 2006. While aggregated data provide insights into how the country as a whole, or even as states, is faring with respect to diabetes mortality, disaggregation provides data that may facilitate targeted interventions and community ...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc13-0988

    authors： Hunt BR,Whitman S,Henry CA

    更新日期：2014-01-01 00:00:00

  • Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo.

    abstract：OBJECTIVE:The purpose of this study was to compare an in vivo test of whole-body glycolysis, the deuterated-glucose disposal test (2H-GDT), with insulin sensitivity measured by the euglycemic-hyperinsulinemic glucose clamp and the steady-state plasma glucose (SSPG) test. RESEARCH DESIGN AND METHODS:The 2H-GDT consists...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc06-1809

    authors： Beysen C,Murphy EJ,McLaughlin T,Riiff T,Lamendola C,Turner HC,Awada M,Turner SM,Reaven G,Hellerstein MK

    更新日期：2007-05-01 00:00:00

  • Comparison of two indices of glycemic control in diabetic subjects: glycosylated serum protein and hemoglobin.

    abstract：:Glycosylated serum protein (GSP) and glycosylated hemoglobin (GHb) were measured in 263 insulin-dependent and 41 non-insulin-dependent diabetic subjects. Both indices provided useful information in type II diabetes, but were extremely poor in judging control in type I diabetes. In both groups, there was poor correlati...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.6.1.34

    authors： Mehl TD,Wenzel SE,Russell B,Gardner D,Merimee TJ

    更新日期：1983-01-01 00:00:00

  • Evaluation of a new measure of blood glucose variability in diabetes.

    abstract：OBJECTIVE:Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia. It is therefore important to design variability measures that are equally predictive of low a...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc06-1085

    authors： Kovatchev BP,Otto E,Cox D,Gonder-Frederick L,Clarke W

    更新日期：2006-11-01 00:00:00

  • Differential associations of oral glucose tolerance test-derived measures of insulin sensitivity and pancreatic β-cell function with coronary artery calcification and microalbuminuria in type 2 diabetes.

    abstract：:OBJECTIVE We evaluated relationships of oral glucose tolerance testing (OGTT)-derived measures of insulin sensitivity and pancreatic β-cell function with indices of diabetes complications in a cross-sectional study of patients with type 2 diabetes who are free of overt cardiovascular or renal disease. RESEARCH DESIGN ...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc12-1880

    authors： Mulvey CK,McNeill AM,Girman CJ,Churchill TW,Terembula K,Ferguson JF,Shah R,Mehta NN,Qasim AN,Rickels MR,Reilly MP

    更新日期：2014-01-01 00:00:00

  • Rarefaction of the peripheral nerve network in diabetic patients is associated with a pronounced reduction of terminal Schwann cells.

    abstract：OBJECTIVE:Peripheral neuropathy is the most frequent neurological complication in diabetic patients. The diagnosis is established by both clinical neurological examination and demonstration of reduced epidermal nerve fibers in skin biopsies (1). Whereas the decrease of free nerve endings has been extensively studied in...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc07-1832

    authors： Reinisch CM,Traxler H,Piringer S,Tangl S,Nader A,Tschachler E

    更新日期：2008-06-01 00:00:00

  • Ethnic differences in correlates of microalbuminuria in NIDDM. The role of the acute-phase response.

    abstract：OBJECTIVE:To investigate whether microalbuminuria is associated with markers of the acute-phase response in NIDDM and whether there are ethnic differences in this association among the three main racial groups in Malaysia. RESEARCH DESIGN AND METHODS:NIDDM patients of Chinese, Indian, and Malay origin attending a diab...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.21.3.385

    authors： Islam N,Kazmi F,Chusney GD,Mattock MB,Zaini A,Pickup JC

    更新日期：1998-03-01 00:00:00

  • Malfunction of continuous subcutaneous insulin infusion systems: a one-year prospective study of 127 patients.

    abstract：:Malfunction of portable continuous subcutaneous insulin infusion (CSII) systems may result in either ketoacidosis or serious hypoglycemia. To determine the types and frequencies of infusion system failure and the resulting clinical consequences, we recorded their occurrences in a 1-yr prospective study of 127 patients...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/diacare.9.4.351

    authors： Mecklenburg RS,Guinn TS,Sannar CA,Blumenstein BA

    更新日期：1986-07-01 00:00:00

  • Hypogonadotropic Hypogonadism in Men With Diabesity.

    abstract：:One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty. The gonadotropin concentrations in these males are inappropriately normal; thus, these pati...

    journal_title：Diabetes care

    pub_type： 杂志文章,评审

    doi：10.2337/dc17-2510

    authors： Dhindsa S,Ghanim H,Batra M,Dandona P

    更新日期：2018-07-01 00:00:00

  • Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model.

    abstract：OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

    journal_title：Diabetes care

    pub_type： 杂志文章

    doi：10.2337/dc07-1304

    authors： Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

    更新日期：2008-01-01 00:00:00