Abstract:
:Exocrine pancreatic insufficiency is frequently associated with diabetes, with high prevalence in both insulin-dependent or insulin-independent patients. Exocrine pancreatic failure has often been perceived as a complication of diabetes. In contrast, recent clinical observations lead to the notion that nonendocrine pancreatic disease is a critical factor for development rather than a sequel to diabetes. The incidence of diabetes caused by exocrine pancreatic disease appears to be underestimated and may comprise 8% or more of the general diabetic patient population. Nonendocrine pancreas disease can cause diabetes by multiple mechanisms. Genetic defects have been characterized, resulting in a syndrome of both exocrine and endocrine failure. Regulation of beta-cell mass and physiological incretin secretion are directly dependent on normal exocrine function. Algorithms for diagnosis and therapy of diabetes should therefore address both endocrine and exocrine pancreatic function.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Hardt PD,Brendel MD,Kloer HU,Bretzel RGdoi
10.2337/dc08-s244subject
Has Abstractpub_date
2008-02-01 00:00:00pages
S165-9eissn
0149-5992issn
1935-5548pii
31/Supplement_2/S165journal_volume
31 Suppl 2pub_type
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