Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?

Abstract:

:Exocrine pancreatic insufficiency is frequently associated with diabetes, with high prevalence in both insulin-dependent or insulin-independent patients. Exocrine pancreatic failure has often been perceived as a complication of diabetes. In contrast, recent clinical observations lead to the notion that nonendocrine pancreatic disease is a critical factor for development rather than a sequel to diabetes. The incidence of diabetes caused by exocrine pancreatic disease appears to be underestimated and may comprise 8% or more of the general diabetic patient population. Nonendocrine pancreas disease can cause diabetes by multiple mechanisms. Genetic defects have been characterized, resulting in a syndrome of both exocrine and endocrine failure. Regulation of beta-cell mass and physiological incretin secretion are directly dependent on normal exocrine function. Algorithms for diagnosis and therapy of diabetes should therefore address both endocrine and exocrine pancreatic function.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Hardt PD,Brendel MD,Kloer HU,Bretzel RG

doi

10.2337/dc08-s244

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

S165-9

eissn

0149-5992

issn

1935-5548

pii

31/Supplement_2/S165

journal_volume

31 Suppl 2

pub_type

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