Abstract:
:Extensive research efforts have been conducted over the past decades to understand the processing of the Amyloid Precursor Protein (APP). APP cleavage leads to the production of the beta-amyloid peptide (Abeta), which is the major constituent of the amyloid core of senile plaques found in the brains of patients with Alzheimer disease (AD). Abeta is produced by the sequential cleavage of APP by beta- and gamma-secretases. Cleavage of APP by gamma-secretase also generates the APP Intracellular C-terminal Domain (AICD) peptide, which might be involved in regulation of gene transcription. Up to now, our understanding of the mechanisms controlling APP processing has been elusive. Recently, APP was found to form homo- or hetero-complexes with the APP-like proteins (APLPs), which belong to the same family and share some important structural properties with receptors having a single membrane spanning domain. Homodimerization of APP is driven by motifs present in the extracellular domain and possibly in the juxtamembrane and transmembrane (JM/TM) domains of the protein. These striking observations raise important questions about APP processing and function: How and where is APP dimerizing? What is the role of dimerization in APP processing and function? Can dimerization be targeted by small molecule therapeutics?
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Khalifa NB,Van Hees J,Tasiaux B,Huysseune S,Smith SO,Constantinescu SN,Octave JN,Kienlen-Campard Pdoi
10.4161/cam.4.2.11476subject
Has Abstractpub_date
2010-04-01 00:00:00pages
268-72issue
2eissn
1933-6918issn
1933-6926pii
11476journal_volume
4pub_type
杂志文章abstract::Adult stem cells generally reside in supporting local micro environments or niches, and intimate stem cell and niche association is critical for their long-term maintenance and function. Recent studies in model organisms especially Drosophila have started to unveil the underlying mechanisms of stem anchorage in the ni...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.4.8604
更新日期:2009-10-01 00:00:00
abstract::Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell adhesion by linking transmembrane proteins to the actin cytoskeleton. Additionally, they participate in recruitment of signaling recept...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21326
更新日期:2012-07-01 00:00:00
abstract::There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources s...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.26941
更新日期:2013-09-01 00:00:00
abstract::The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2017.1405208
更新日期:2018-01-01 00:00:00
abstract::The mechanical and structural properties of the extracellular matrix (ECM) play an important role in regulating cell fate. The natural ECM has a complex fibrillar structure and shows nonlinear mechanical properties, which are both difficult to mimic synthetically. Therefore, systematically testing the influence of ECM...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1151607
更新日期:2016-09-02 00:00:00
abstract::Spinal cord injury (SCI) has been regarded clinically as an irreversible damage caused by tissue contusion due to a blunt external force. Past research had focused on the analysis of the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as tissue damage and neural cell d...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.1.7372
更新日期:2009-01-01 00:00:00
abstract::ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa GTPase with homology to Ras. Re-expression of ARHI inhibits ovarian cancer growth, initiates autophagy and induces tumor dormancy. Recent studies have...
journal_title:Cell adhesion & migration
pub_type: 评论,杂志文章
doi:10.4161/cam.23648
更新日期:2013-03-01 00:00:00
abstract::The goal of this review is to highlight how emerging new models of filopodia assembly, which include tissue specific actin-bundling proteins, could provide more comprehensive representations of filopodia assembly that would describe more adequately and effectively the complexity and plasticity of epithelial cells. Th...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.5.17644
更新日期:2011-09-01 00:00:00
abstract::In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions charact...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.23130
更新日期:2013-03-01 00:00:00
abstract::The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as prolife...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.20631
更新日期:2012-05-01 00:00:00
abstract::Normal vascular development and angiogenesis is regulated by coordinated changes in cell-cell and cell-extracellular matrix (ECM) interactions. The Homeobox (Hox) family of transcription factors coordinately regulate expression of matrix degrading proteinases, integrins and ECM components and profoundly impact vascula...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.1.4.5448
更新日期:2007-10-01 00:00:00
abstract::The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2019.1587269
更新日期:2019-12-01 00:00:00
abstract::It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus wh...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.28437
更新日期:2014-01-01 00:00:00
abstract::Galectin-1 (gal-1), a member of the mammalian β-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation. In previous studies, we demonstrated that gal-1 induces cell differentiation processes on the membrane of choriocarc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1089377
更新日期:2016-03-03 00:00:00
abstract::Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell. Recent findings implicate cyc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.3.11131
更新日期:2010-07-01 00:00:00
abstract::The ability of blood vessels to sense and respond to stimuli such as fluid flow, shear stress, and trafficking of immune cells is critical to the proper function of the vascular system. Endothelial cells constantly remodel their cell-cell junctions and the underlying cytoskeletal network in response to these exogenous...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.28115
更新日期:2014-01-01 00:00:00
abstract::The hypotheses emerging from basic research on colorectal liver metastases must be tested in clinical situations for the adaptation of current treatment strategies. Pre-metastatic niches have been shown to exist in human colorectal synchronous metastases, with the liver parenchyma adjacent to the synchronous liver met...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.23247
更新日期:2012-11-01 00:00:00
abstract::An expanding body of evidence demonstrates that cells undergoing apoptosis send out a selection of molecular navigational signals including proteins, lipids and nucleotides that serve to recruit phagocytes to the dying targets which are subsequently engulfed and removed. This homeostatic process is essentially non-phl...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.5.4.16743
更新日期:2011-07-01 00:00:00
abstract::Cell surface receptors of the integrin family are pivotal to cell adhesion and migration. The activation state of heterodimeric alphabeta integrins is correlated to the association state of the single-pass alpha and beta transmembrane domains. The association of integrin alphaIIbbeta3 transmembrane domains, resulting ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.2.10592
更新日期:2010-04-01 00:00:00
abstract::Genetically engineered, conditionally replicating herpes simplex viruses type 1 (HSV-1) are promising therapeutic agents for brain tumors and other solid cancers. They can replicate in situ, spread and exhibit oncolytic activity via a direct cytocidal effect. One of the advantages of HSV-1 is the capacity to incorpora...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.3.6353
更新日期:2008-07-01 00:00:00
abstract::Physical cues from the extracellular environment that influence cell shape and directional migration are transduced into changes in cytoskeletal organization and biochemistry through integrin-based cell adhesions to extracellular matrix (ECM). Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin a...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.21672
更新日期:2012-11-01 00:00:00
abstract::Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-th...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.29139
更新日期:2014-01-01 00:00:00
abstract::Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1120397
更新日期:2016-03-03 00:00:00
abstract::Adhesion of epithelial cell to each other and to extracellular matrix, as well as cell migration ability and cytoskeleton organization undergo significant alterations in the course of neoplastic transformation, but regulatory mechanisms involved in these processes are not fully understood. Here, we studied the role of...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1227910
更新日期:2017-07-04 00:00:00
abstract::Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2018.1494997
更新日期:2019-12-01 00:00:00
abstract::Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.26375
更新日期:2013-09-01 00:00:00
abstract::Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are assoc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.28182
更新日期:2014-01-01 00:00:00
abstract::Optimising response to tyrosine kinase inhibitors in cancer remains an extensive field of research. Intravital imaging is an emerging tool, which can be used in drug discovery to facilitate and fine-tune maximum drug response in live tumors. A greater understanding of intratumoural delivery and pharmacodynamics of a d...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/19336918.2014.970004
更新日期:2014-01-01 00:00:00
abstract::In addition to its well-defined role as an antagonist in apoptosis, we propose that BCL2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. Our evidence shows that, when over-expressed in both cancer and non-cancer cells, BCL2 can form a complex with actin and gelsolin that ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.5.1.13175
更新日期:2011-01-01 00:00:00
abstract::In the cortex of a motile cell, membrane-anchored actin filaments assemble into structures of varying shape and function. Filopodia are distinguished by a core of bundled actin filaments within finger-like extensions of the membrane. In a recent paper by Medalia et al(1) cryo-electron tomography has been used to recon...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.1.3.4662
更新日期:2007-07-01 00:00:00