Abstract:
:Spinal cord injury (SCI) has been regarded clinically as an irreversible damage caused by tissue contusion due to a blunt external force. Past research had focused on the analysis of the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as tissue damage and neural cell death associated with secondary injury. Recent studies, however, have proven that neural stem (progenitor) cells are also present in the brain and spinal cord of adult mammals including humans. Analyses using spinal cord injury models have also demonstrated active dynamics of cells expressing several stem cell markers, and methods aiming at functional reconstruction by promoting the potential self-regeneration capacity of the spinal cord are being explored. Furthermore, reconstruction of the neural circuit requires not only replenishment or regeneration of neural cells but also regeneration of axons. Analysis of the tissue microenvironment after spinal cord injury and research aiming to remove axonal regeneration inhibitors have also made progress. SCI is one of the simplest central nervous injuries, but its pathogenesis is associated with diverse factors, and further studies are required to elucidate these complex interactions in order to achieve spinal cord regeneration and functional reconstruction.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Shibuya S,Yamamoto T,Itano Tdoi
10.4161/cam.3.1.7372subject
Has Abstractpub_date
2009-01-01 00:00:00pages
99-106issue
1eissn
1933-6918issn
1933-6926pii
7372journal_volume
3pub_type
杂志文章,评审abstract::All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus wh...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.28437
更新日期:2014-01-01 00:00:00
abstract::Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in the cerebrospinal fluid. Nevertheless, its role in the central nervous system is far from clear. Here, we present evidence that L-PGDS induces glial cell migration and morphological changes in vitro and in vivo. We also identified...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.20251
更新日期:2012-05-01 00:00:00
abstract::Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adhesions in the cell....
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.2.10888
更新日期:2010-04-01 00:00:00
abstract::It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.4.4.13594
更新日期:2010-10-01 00:00:00
abstract::Genetically engineered, conditionally replicating herpes simplex viruses type 1 (HSV-1) are promising therapeutic agents for brain tumors and other solid cancers. They can replicate in situ, spread and exhibit oncolytic activity via a direct cytocidal effect. One of the advantages of HSV-1 is the capacity to incorpora...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.3.6353
更新日期:2008-07-01 00:00:00
abstract::Normal vascular development and angiogenesis is regulated by coordinated changes in cell-cell and cell-extracellular matrix (ECM) interactions. The Homeobox (Hox) family of transcription factors coordinately regulate expression of matrix degrading proteinases, integrins and ECM components and profoundly impact vascula...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.1.4.5448
更新日期:2007-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2014.1000072
更新日期:2015-01-01 00:00:00
abstract::Tumor budding occurs at the invasive front of cancer; the tumor cells involved have metastatic and stemness features, indicating a poor prognosis. Tumor budding is partly responsible for cancer metastasis, and its initiation is based on the epithelial-mesenchymal transition (EMT) process. The EMT process involves the ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1129481
更新日期:2016-07-03 00:00:00
abstract::Extensive research efforts have been conducted over the past decades to understand the processing of the Amyloid Precursor Protein (APP). APP cleavage leads to the production of the beta-amyloid peptide (Abeta), which is the major constituent of the amyloid core of senile plaques found in the brains of patients with A...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.2.11476
更新日期:2010-04-01 00:00:00
abstract::Coordinated changes of actin cytoskeleton and cell adhesion accompany maturation of lymphoid cells, their migration through lymphoid organs and to sites of inflammation, as well as metastasis of transformed cells. Here we discuss the central role of the actin-regulating adaptor protein, paxillin, during lymphocyte tra...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.6.18219
更新日期:2011-11-01 00:00:00
abstract::Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2018.1494997
更新日期:2019-12-01 00:00:00
abstract::During an infection, neutrophils are the first immune cells to arrive armed to clear the invading pathogen. In order to do so, neutrophils need to transmigrate from the peripheral blood through the endothelial layer toward the site of inflammation. This process is in most cases dependent on integrins, adhesion molecul...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.27293
更新日期:2013-11-01 00:00:00
abstract::The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2019.1587269
更新日期:2019-12-01 00:00:00
abstract::The term polarity refers to the differential distribution of the macromolecular elements of a cell, resulting in its asymmetry in function, shape and/or content. Polarity is a fundamental property of all metazoan cells in at least some stages, and is pivotal to processes such as epithelial differentiation (apical/basa...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.1.2.4547
更新日期:2007-04-01 00:00:00
abstract::Discovered decades ago, extracellular vesicles (EVs) emerge as dedicated organelles, able to deliver protected, specific cellular cues throughout the organism. While virtually every cell can release EVs, cancer cells co-opted this feature and efficiently unleashed them both in the tumor microenvironment and toward hea...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1247145
更新日期:2017-03-04 00:00:00
abstract::Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This m...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1173800
更新日期:2016-09-02 00:00:00
abstract::The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p5...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.2.14375
更新日期:2011-03-01 00:00:00
abstract::In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions charact...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.23130
更新日期:2013-03-01 00:00:00
abstract::Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-th...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.29139
更新日期:2014-01-01 00:00:00
abstract::The class-specific transcription factors Knot and Cut act during dendrite arbor development to define the characteristic dendrite branching pattern of the Drosophila class IV dendritic arborisation sensory neurons. Knot mediates dendrite arbor outgrowth and branching via a microtubule-based program that includes upreg...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.2.6395
更新日期:2008-04-01 00:00:00
abstract::Since the time it was pioneered in 1992, intravital imaging of tumors at cellular resolution has offered us the extremely important opportunity of "seeing biology." However, until now, most studies were monitoring tumor cell behavior in the same animal over short times, requiring the combining of acquired data into a ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.4.9581
更新日期:2009-10-01 00:00:00
abstract::Growth factors regulate a diverse array of cellular functions including proliferation, survival, movement, and the ability to do this often involves interactions with the extracellular matrix (ECM) and particularly heparan sulfate proteoglycans (HSPGs). HSPGs have been shown to sequester growth factors, and to act as ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.4.12427
更新日期:2010-10-01 00:00:00
abstract::In this article, I discuss the hallmarks of hypoxia in vitro and in vivo and review work showing that many types of stem cell proliferate more robustly in lowered oxygen. I then discuss recent studies showing that alterations in the levels and the types of cell and substrate adhesion molecules are a notable response t...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.19582
更新日期:2012-01-01 00:00:00
abstract::Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryoni...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.4.4.12829
更新日期:2010-10-01 00:00:00
abstract::The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2017.1405208
更新日期:2018-01-01 00:00:00
abstract::The conserved polarity proteins Par6 and aPKC regulate cell polarization processes. However, increasing evidence also suggests that they play a role in oncogenic progression. During tumor progression, epithelial to mesenchymal transition (EMT) delineates an evolutionary conserved process that converts stationary epith...
journal_title:Cell adhesion & migration
pub_type: 评论,杂志文章
doi:10.4161/cam.25651
更新日期:2013-07-01 00:00:00
abstract::The mechanical and structural properties of the extracellular matrix (ECM) play an important role in regulating cell fate. The natural ECM has a complex fibrillar structure and shows nonlinear mechanical properties, which are both difficult to mimic synthetically. Therefore, systematically testing the influence of ECM...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1151607
更新日期:2016-09-02 00:00:00
abstract::The proper establishment and organogenesis of the placenta is crucial for intrauterine fetal growth and development. Endometrial invasion by the extravillous trophoblast cells, as well as formation of the syncytiotrophoblast (STB), are of vital importance for placental function. Trophoblast migration and invasion is o...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1098800
更新日期:2016-03-03 00:00:00
abstract::The actin cytoskeleton plays a key role in regulating cell motility. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells that is conserved among a variety of vertebrates. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.2.14398
更新日期:2011-03-01 00:00:00