Abstract:
:The actin cytoskeleton plays a key role in regulating cell motility. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells that is conserved among a variety of vertebrates. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. CaD function is regulated qualitatively by Ca2+/CaM and by its phosphorylation state and quantitatively at the mRNA level, by three different transcriptional regulation of the CALD1 gene. CaD has numerous functions in cell motility, such as migration, invasion, and proliferation, exerted via the reorganization of the actin cytoskeleton. Here we will outline recent findings regarding CaD's structural features and functions.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Mayanagi T,Sobue Kdoi
10.4161/cam.5.2.14398subject
Has Abstractpub_date
2011-03-01 00:00:00pages
150-9issue
2eissn
1933-6918issn
1933-6926pii
14398journal_volume
5pub_type
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