BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization.

abstract：:The ability of blood vessels to sense and respond to stimuli such as fluid flow, shear stress, and trafficking of immune cells is critical to the proper function of the vascular system. Endothelial cells constantly remodel their cell-cell junctions and the underlying cytoskeletal network in response to these exogenous...

journal_title：Cell adhesion & migration

authors： Wilson CW,Ye W

更新日期：2014-01-01 00:00:00

abstract：:Familial dysautonomia (FD) is a hereditary neuronal disease characterized by poor development and progressive degeneration of the sensory and autonomic nervous system. Majority of FD (99.5%) results from a single nucleotide point mutation in the IKBKAP gene encoding IKAP, also known as elongation protein 1 (ELP1). The...

journal_title：Cell adhesion & migration

authors： Naumanen T,Johansen LD,Coffey ET,Kallunki T

更新日期：2008-10-01 00:00:00

abstract：:Tumor budding occurs at the invasive front of cancer; the tumor cells involved have metastatic and stemness features, indicating a poor prognosis. Tumor budding is partly responsible for cancer metastasis, and its initiation is based on the epithelial-mesenchymal transition (EMT) process. The EMT process involves the ...

journal_title：Cell adhesion & migration

authors： Li H,Xu F,Li S,Zhong A,Meng X,Lai M

更新日期：2016-07-03 00:00:00

abstract：:PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpr...

journal_title：Cell adhesion & migration

authors： Pang Y,Zhang Z,Wang Z,Wang Y,Yan Y,Li S,Tong H

更新日期：2019-12-01 00:00:00

abstract：:All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of...

journal_title：Cell adhesion & migration

authors： Mazzon C,Viola A

更新日期：2007-01-01 00:00:00

abstract：:Galectin-1 (gal-1), a member of the mammalian β-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation. In previous studies, we demonstrated that gal-1 induces cell differentiation processes on the membrane of choriocarc...

journal_title：Cell adhesion & migration

authors： Hutter S,Morales-Prieto DM,Andergassen U,Tschakert L,Kuhn C,Hofmann S,Markert UR,Jeschke U

更新日期：2016-03-03 00:00:00

abstract：:Cell surface receptors of the integrin family are pivotal to cell adhesion and migration. The activation state of heterodimeric alphabeta integrins is correlated to the association state of the single-pass alpha and beta transmembrane domains. The association of integrin alphaIIbbeta3 transmembrane domains, resulting ...

journal_title：Cell adhesion & migration

authors： Ulmer TS

更新日期：2010-04-01 00:00:00

abstract：:Discovered decades ago, extracellular vesicles (EVs) emerge as dedicated organelles, able to deliver protected, specific cellular cues throughout the organism. While virtually every cell can release EVs, cancer cells co-opted this feature and efficiently unleashed them both in the tumor microenvironment and toward hea...

journal_title：Cell adhesion & migration

authors： André-Grégoire G,Gavard J

更新日期：2017-03-04 00:00:00

abstract：:Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds...

journal_title：Cell adhesion & migration

authors： Arriagada C,Silva P,Torres VA

更新日期：2019-12-01 00:00:00

abstract：:Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis. Bone remodeling consists of two phases: the removal of mineralized bone by osteoclasts and the formation of ne...

journal_title：Cell adhesion & migration

authors： Xu R

更新日期：2014-01-01 00:00:00

abstract：:It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...

journal_title：Cell adhesion & migration

authors： Krull CE

更新日期：2010-10-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in humans. They are involved in several inflammatory disorders, including the pathogenesis of inflammatory bowel disease (IBD). A recent paper showed that activated MAPK are upregulated on endothelium and fibroblasts from int...

journal_title：Cell adhesion & migration

authors： Scaldaferri F,Correale C,Gasbarrini A,Danese S

更新日期：2009-07-01 00:00:00

abstract：:During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules ...

journal_title：Cell adhesion & migration

authors： Basu R,Taylor MR,Williams ME

更新日期：2015-01-01 00:00:00

abstract：:In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions charact...

journal_title：Cell adhesion & migration

authors： Galkina SI,Fedorova NV,Stadnichuk VI,Sud'ina GF

更新日期：2013-03-01 00:00:00

abstract：:The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces ...

journal_title：Cell adhesion & migration

authors： Anderson NR,Buffone A Jr,Hammer DA

更新日期：2019-12-01 00:00:00

abstract：:Cellular studies have long been performed on the bench top, within Petri dishes and flasks that expose cells to surroundings that differ greatly from their native environment. The complexity of a human tissue is such that to truly replicate a cell's physiologic microenvironment in vitro is currently impossible. It is ...

journal_title：Cell adhesion & migration

authors： Kraning-Rush CM,Reinhart-King CA

更新日期：2012-05-01 00:00:00

abstract：:Cellular motility is a fundamental process essential for embryonic development, wound healing, immune responses, and tissues development. Cells are mostly moving by crawling on external, or inside, substrates which can differ in their surface composition, geometry, and dimensionality. Cells can adopt different migrati...

journal_title：Cell adhesion & migration

authors： Siton-Mendelson O,Bernheim-Groswasser A

更新日期：2016-09-02 00:00:00

abstract：:Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...

journal_title：Cell adhesion & migration

authors： Silva JF,Serakides R

更新日期：2016-03-03 00:00:00

abstract：:Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adhesions in the cell....

journal_title：Cell adhesion & migration

authors： Bach CT,Schevzov G,Bryce NS,Gunning PW,O'Neill GM

更新日期：2010-04-01 00:00:00

abstract：:The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences i...

journal_title：Cell adhesion & migration

authors： Fagotto F,Winklbauer R,Rohani N

更新日期：2014-01-01 00:00:00

abstract：:Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This m...

journal_title：Cell adhesion & migration

authors： Gupta M,Doss B,Lim CT,Voituriez R,Ladoux B

更新日期：2016-09-02 00:00:00

abstract：:Cancer exosomes are gaining considerable amount of attention in basic and applied clinical research for their established role in the modulation of the tumor niche, and their broad-range contribution to tumor-host cross-talk. Supporting evidence to their role in tumorigenesis comes from the observation that exosome se...

journal_title：Cell adhesion & migration

authors： Fares J,Kashyap R,Zimmermann P

更新日期：2017-03-04 00:00:00

abstract：:Directional cell migration is essential for almost all organisms during embryonic development, in adult life and contributes to pathological conditions. This is particularly critical during embryogenesis where it is essential that cells end up in their correct, precise locations in order to build a normal embryo. Many...

journal_title：Cell adhesion & migration

authors： Carmona-Fontaine C,Matthews H,Mayor R

更新日期：2008-10-01 00:00:00

abstract：:For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...

journal_title：Cell adhesion & migration

authors： Khanna A,Indracanti N,Chakrabarti R,Indraganti PK

更新日期：2020-12-01 00:00:00

abstract：:Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell adhesion by linking transmembrane proteins to the actin cytoskeleton. Additionally, they participate in recruitment of signaling recept...

journal_title：Cell adhesion & migration

authors： Le Bras GF,Taubenslag KJ,Andl CD

更新日期：2012-07-01 00:00:00

abstract：:Normal vascular development and angiogenesis is regulated by coordinated changes in cell-cell and cell-extracellular matrix (ECM) interactions. The Homeobox (Hox) family of transcription factors coordinately regulate expression of matrix degrading proteinases, integrins and ECM components and profoundly impact vascula...

journal_title：Cell adhesion & migration

authors： Arderiu G,Cuevas I,Chen A,Carrio M,East L,Boudreau NJ

更新日期：2007-10-01 00:00:00

abstract：:Monocyte-extracellular matrix interactions have been implicated in atherosclerosis pathophysiology. Laminin, the main basement membrane protein contains cell binding domains that can be cryptic, presented only after protein modification. In the present study we evaluated monocyte attachment to laminin-1 in the presenc...

journal_title：Cell adhesion & migration

authors： Kostidou E,Trachana V,Topouridou K,Paletas K,Tsapas A,Kaloyianni M,Koliakos G

更新日期：2009-04-01 00:00:00

abstract：:ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa GTPase with homology to Ras. Re-expression of ARHI inhibits ovarian cancer growth, initiates autophagy and induces tumor dormancy. Recent studies have...

journal_title：Cell adhesion & migration

authors： Lu Z,Bast RC Jr

更新日期：2013-03-01 00:00:00

abstract：:During an infection, neutrophils are the first immune cells to arrive armed to clear the invading pathogen. In order to do so, neutrophils need to transmigrate from the peripheral blood through the endothelial layer toward the site of inflammation. This process is in most cases dependent on integrins, adhesion molecul...

journal_title：Cell adhesion & migration

authors： Langereis JD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tum...

journal_title：Cell adhesion & migration

authors： Hohmann T,Grabiec U,Ghadban C,Feese K,Dehghani F

更新日期：2017-01-02 00:00:00