Abstract:
:During an infection, neutrophils are the first immune cells to arrive armed to clear the invading pathogen. In order to do so, neutrophils need to transmigrate from the peripheral blood through the endothelial layer toward the site of inflammation. This process is in most cases dependent on integrins, adhesion molecules present on all immune cells. These molecules are functionally regulated by "inside-out" signaling, where stimulus-induced signaling pathways act on the intracellular integrin tail to regulate the activity of the receptor on the outside. Both a change in conformation (affinity) and clustering (avidity/valency) of the receptors occurs and many factors have been linked to regulation of integrins on neutrophils. Control of integrin conformation and clustering is of pivotal importance for proper cell adhesion, migration, and bacterial clearance. Recently, gelsolin was found to be involved in β 1-integrin affinity regulation and cell adhesion. Here, I summarize the role of neutrophil integrin regulation in the essential steps to reach the site of inflammation and clearance of bacterial pathogens.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Langereis JDdoi
10.4161/cam.27293subject
Has Abstractpub_date
2013-11-01 00:00:00pages
476-81issue
6eissn
1933-6918issn
1933-6926pii
27293journal_volume
7pub_type
杂志文章,评审abstract::The class-specific transcription factors Knot and Cut act during dendrite arbor development to define the characteristic dendrite branching pattern of the Drosophila class IV dendritic arborisation sensory neurons. Knot mediates dendrite arbor outgrowth and branching via a microtubule-based program that includes upreg...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.2.6395
更新日期:2008-04-01 00:00:00
abstract::Adhesion of epithelial cell to each other and to extracellular matrix, as well as cell migration ability and cytoskeleton organization undergo significant alterations in the course of neoplastic transformation, but regulatory mechanisms involved in these processes are not fully understood. Here, we studied the role of...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1227910
更新日期:2017-07-04 00:00:00
abstract::The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1093275
更新日期:2016-03-03 00:00:00
abstract::Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are assoc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.28182
更新日期:2014-01-01 00:00:00
abstract::Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion form...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1221563
更新日期:2016-09-02 00:00:00
abstract::Coordinated changes of actin cytoskeleton and cell adhesion accompany maturation of lymphoid cells, their migration through lymphoid organs and to sites of inflammation, as well as metastasis of transformed cells. Here we discuss the central role of the actin-regulating adaptor protein, paxillin, during lymphocyte tra...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.6.18219
更新日期:2011-11-01 00:00:00
abstract::An expanding body of evidence demonstrates that cells undergoing apoptosis send out a selection of molecular navigational signals including proteins, lipids and nucleotides that serve to recruit phagocytes to the dying targets which are subsequently engulfed and removed. This homeostatic process is essentially non-phl...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.5.4.16743
更新日期:2011-07-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.3.8858
更新日期:2009-07-01 00:00:00
abstract::When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn dete...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1083667
更新日期:2016-03-03 00:00:00
abstract::Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.26375
更新日期:2013-09-01 00:00:00
abstract::Visceral adipose tissue (VAT) may play a critical role in atherosclerotic cardiovascular disease. The goal of this study was to determine the effect of human VAT-released pro‑inflammatory cytokines on monocyte adhesion to the endothelium. The cytokine effects on monocyte adhesion to the endothelial cells (ECs) were te...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2019.1644856
更新日期:2019-12-01 00:00:00
abstract::For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2020.1842131
更新日期:2020-12-01 00:00:00
abstract::There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources s...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.26941
更新日期:2013-09-01 00:00:00
abstract::Acute mountain sickness (AMS) can cause capillary hyper-permeability and vasogenic edema. However, its underlying mechanisms remained unclear and there is no previous in vitro study on AMS. We therefore conducted an in vitro study and examined whether continuous hypobaric hypoxia (CHH) could alter expression of juncti...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1225633
更新日期:2017-07-04 00:00:00
abstract::Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1120397
更新日期:2016-03-03 00:00:00
abstract::The conserved polarity proteins Par6 and aPKC regulate cell polarization processes. However, increasing evidence also suggests that they play a role in oncogenic progression. During tumor progression, epithelial to mesenchymal transition (EMT) delineates an evolutionary conserved process that converts stationary epith...
journal_title:Cell adhesion & migration
pub_type: 评论,杂志文章
doi:10.4161/cam.25651
更新日期:2013-07-01 00:00:00
abstract::Since the time it was pioneered in 1992, intravital imaging of tumors at cellular resolution has offered us the extremely important opportunity of "seeing biology." However, until now, most studies were monitoring tumor cell behavior in the same animal over short times, requiring the combining of acquired data into a ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.4.9581
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tum...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1183867
更新日期:2017-01-02 00:00:00
abstract::Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis. Bone remodeling consists of two phases: the removal of mineralized bone by osteoclasts and the formation of ne...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.27752
更新日期:2014-01-01 00:00:00
abstract::PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2019.1619434
更新日期:2019-12-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.20154
更新日期:2012-03-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21326
更新日期:2012-07-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.28115
更新日期:2014-01-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2014.1000072
更新日期:2015-01-01 00:00:00
abstract::The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2017.1405208
更新日期:2018-01-01 00:00:00
abstract::In this article, I discuss the hallmarks of hypoxia in vitro and in vivo and review work showing that many types of stem cell proliferate more robustly in lowered oxygen. I then discuss recent studies showing that alterations in the levels and the types of cell and substrate adhesion molecules are a notable response t...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.19582
更新日期:2012-01-01 00:00:00
abstract::Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell. Recent findings implicate cyc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.3.11131
更新日期:2010-07-01 00:00:00
abstract::Adult stem cells generally reside in supporting local micro environments or niches, and intimate stem cell and niche association is critical for their long-term maintenance and function. Recent studies in model organisms especially Drosophila have started to unveil the underlying mechanisms of stem anchorage in the ni...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.4.8604
更新日期:2009-10-01 00:00:00
abstract::Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.22236
更新日期:2013-01-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2018.1475803
更新日期:2018-01-01 00:00:00