Abstract:
:Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical "core-ring" model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
van den Dries K,Bolomini-Vittori M,Cambi Adoi
10.4161/cam.28182subject
Has Abstractpub_date
2014-01-01 00:00:00pages
268-72issue
3eissn
1933-6918issn
1933-6926pii
28182journal_volume
8pub_type
杂志文章,评审abstract::Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in humans. They are involved in several inflammatory disorders, including the pathogenesis of inflammatory bowel disease (IBD). A recent paper showed that activated MAPK are upregulated on endothelium and fibroblasts from int...
journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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更新日期:2011-07-01 00:00:00
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journal_title:Cell adhesion & migration
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pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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