"Armed" oncolytic herpes simplex viruses for brain tumor therapy.

abstract：:Extensive research efforts have been conducted over the past decades to understand the processing of the Amyloid Precursor Protein (APP). APP cleavage leads to the production of the beta-amyloid peptide (Abeta), which is the major constituent of the amyloid core of senile plaques found in the brains of patients with A...

journal_title：Cell adhesion & migration

authors： Khalifa NB,Van Hees J,Tasiaux B,Huysseune S,Smith SO,Constantinescu SN,Octave JN,Kienlen-Campard P

更新日期：2010-04-01 00:00:00

abstract：:Eph receptors and their membrane-bound ligands are intimately involved in the control of morphogenic processes during embryonic development and adult tissue homeostasis. By their ability to orchestrate cell migration, pattern formation and tissue integrity they are also prone to be involved in carcinogenic growth. In ...

journal_title：Cell adhesion & migration

authors： Kaenel P,Mosimann M,Andres AC

更新日期：2012-03-01 00:00:00

abstract：:Discoidin domain receptors 1 and 2 (DDR1 and DDR2) are members of the tyrosine kinase receptors activated after binding with collagen. DDRs are implicated in numerous physiological and pathological functions such as proliferation, adhesion and migration. Little is known about the expression of the two receptors in nor...

journal_title：Cell adhesion & migration

authors： Croissant C,Tuariihionoa A,Bacou M,Souleyreau W,Sala M,Henriet E,Bikfalvi A,Saltel F,Auguste P

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to compare uniaxial traction forces exerted by different cell types using a novel sensor design and to test the dependence of measured forces on cytoskeletal integrity. The sensor design detects forces generated between 2 contact points by cells spanning a gap. The magnitude of these forces v...

journal_title：Cell adhesion & migration

authors： Swierczewski R,Hedley J,Redfern CP

更新日期：2016-05-03 00:00:00

abstract：:For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...

journal_title：Cell adhesion & migration

authors： Khanna A,Indracanti N,Chakrabarti R,Indraganti PK

更新日期：2020-12-01 00:00:00

abstract：:The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as prolife...

journal_title：Cell adhesion & migration

authors： Horimoto Y,Polanska UM,Takahashi Y,Orimo A

更新日期：2012-05-01 00:00:00

abstract：:Monocyte-extracellular matrix interactions have been implicated in atherosclerosis pathophysiology. Laminin, the main basement membrane protein contains cell binding domains that can be cryptic, presented only after protein modification. In the present study we evaluated monocyte attachment to laminin-1 in the presenc...

journal_title：Cell adhesion & migration

authors： Kostidou E,Trachana V,Topouridou K,Paletas K,Tsapas A,Kaloyianni M,Koliakos G

更新日期：2009-04-01 00:00:00

abstract：:All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of...

journal_title：Cell adhesion & migration

authors： Mazzon C,Viola A

更新日期：2007-01-01 00:00:00

abstract：:Eph signaling, which arises following stimulation by ephrins, is known to induce opposite cell behaviors such as promoting and inhibiting cell adhesion as well as promoting cell-cell adhesion and repulsion by altering the organization of the actin cytoskeleton and influencing the adhesion activities of integrins. Howe...

journal_title：Cell adhesion & migration

authors： Saeki N,Nishino S,Shimizu T,Ogawa K

更新日期：2015-01-01 00:00:00

abstract：:A deterministic model of dermal wound invasion, which accounts for the platelet-derived growth factor (PDGF) gradient sensing mechanism in fibroblasts mediated by cell surface receptors and the phosphoinositide 3-kinase (PI3K) signal transduction pathway, was previously described (Biophys J 2006; 90:2297-308). Here, w...

journal_title：Cell adhesion & migration

authors： Monine MI,Haugh JM

更新日期：2008-04-01 00:00:00

abstract：:The proper establishment and organogenesis of the placenta is crucial for intrauterine fetal growth and development. Endometrial invasion by the extravillous trophoblast cells, as well as formation of the syncytiotrophoblast (STB), are of vital importance for placental function. Trophoblast migration and invasion is o...

journal_title：Cell adhesion & migration

authors： Kohan-Ghadr HR,Kadam L,Jain C,Armant DR,Drewlo S

更新日期：2016-03-03 00:00:00

abstract：:It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...

journal_title：Cell adhesion & migration

authors： Krull CE

更新日期：2010-10-01 00:00:00

abstract：:Directional cell migration requires cell polarization and asymmetric distribution of cell signaling. Focal adhesions and microtubules are two systems which are essential for these. It was shown that these two systems closely interact with each other. It is known that microtubule targeting stimulates focal adhesion dis...

journal_title：Cell adhesion & migration

authors： Efimov A,Kaverina I

更新日期：2009-07-01 00:00:00

abstract：:Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis. Bone remodeling consists of two phases: the removal of mineralized bone by osteoclasts and the formation of ne...

journal_title：Cell adhesion & migration

authors： Xu R

更新日期：2014-01-01 00:00:00

abstract：:The hypotheses emerging from basic research on colorectal liver metastases must be tested in clinical situations for the adaptation of current treatment strategies. Pre-metastatic niches have been shown to exist in human colorectal synchronous metastases, with the liver parenchyma adjacent to the synchronous liver met...

journal_title：Cell adhesion & migration

authors： Eveno C,Pocard M

更新日期：2012-11-01 00:00:00

abstract：:Growth factors regulate a diverse array of cellular functions including proliferation, survival, movement, and the ability to do this often involves interactions with the extracellular matrix (ECM) and particularly heparan sulfate proteoglycans (HSPGs). HSPGs have been shown to sequester growth factors, and to act as ...

journal_title：Cell adhesion & migration

authors： Symes K,Smith EM,Mitsi M,Nugent MA

更新日期：2010-10-01 00:00:00

abstract：:The mechanical and structural properties of the extracellular matrix (ECM) play an important role in regulating cell fate. The natural ECM has a complex fibrillar structure and shows nonlinear mechanical properties, which are both difficult to mimic synthetically. Therefore, systematically testing the influence of ECM...

journal_title：Cell adhesion & migration

authors： Bruekers SM,Jaspers M,Hendriks JM,Kurniawan NA,Koenderink GH,Kouwer PH,Rowan AE,T S Huck W

更新日期：2016-09-02 00:00:00

abstract：:Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...

journal_title：Cell adhesion & migration

authors： La Gatta A,D'Agostino A,Schiraldi C,Colella G,Cirillo N

更新日期：2019-12-01 00:00:00

abstract：:ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa GTPase with homology to Ras. Re-expression of ARHI inhibits ovarian cancer growth, initiates autophagy and induces tumor dormancy. Recent studies have...

journal_title：Cell adhesion & migration

authors： Lu Z,Bast RC Jr

更新日期：2013-03-01 00:00:00

abstract：:The critical role of migration and invasion in cancer metastasis warrants new therapeutic approaches targeting the machinery regulating cell migration and invasion. While 2-dimensional (2D) models have helped identify a range of adhesion molecules, cytoskeletal components and regulators that are potentially important ...

journal_title：Cell adhesion & migration

authors： Bradbury P,Fabry B,O'Neill GM

更新日期：2012-09-01 00:00:00

abstract：:Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryoni...

journal_title：Cell adhesion & migration

authors： Smith CL,Tallquist MD

更新日期：2010-10-01 00:00:00

abstract：:Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-th...

journal_title：Cell adhesion & migration

authors： Dumbauld DW,García AJ

更新日期：2014-01-01 00:00:00

abstract：:Although epithelial to mesenchymal transitions (EMT) are often viewed as a unique event, they are characterized by a great diversity of cellular processes resulting in strikingly different outcomes. They may be complete or partial, massive or progressive, and lead to the complete disruption of the epithelium or leave ...

journal_title：Cell adhesion & migration

authors： Duband JL

更新日期：2010-07-01 00:00:00

abstract：:The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with...

journal_title：Cell adhesion & migration

authors： Candelier JJ

更新日期：2016-03-03 00:00:00

abstract：:An expanding body of evidence demonstrates that cells undergoing apoptosis send out a selection of molecular navigational signals including proteins, lipids and nucleotides that serve to recruit phagocytes to the dying targets which are subsequently engulfed and removed. This homeostatic process is essentially non-phl...

journal_title：Cell adhesion & migration

authors： Gregory CD,Rossi AG,Bournazou I,Zhuang L,Willems JJ

更新日期：2011-07-01 00:00:00

abstract：:The actin cytoskeleton plays a key role in regulating cell motility. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells that is conserved among a variety of vertebrates. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (...

journal_title：Cell adhesion & migration

authors： Mayanagi T,Sobue K

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tum...

journal_title：Cell adhesion & migration

authors： Hohmann T,Grabiec U,Ghadban C,Feese K,Dehghani F

更新日期：2017-01-02 00:00:00

abstract：:When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn dete...

journal_title：Cell adhesion & migration

authors： James J,Tun W,Clark A

更新日期：2016-03-03 00:00:00

abstract：:The ability of blood vessels to sense and respond to stimuli such as fluid flow, shear stress, and trafficking of immune cells is critical to the proper function of the vascular system. Endothelial cells constantly remodel their cell-cell junctions and the underlying cytoskeletal network in response to these exogenous...

journal_title：Cell adhesion & migration

authors： Wilson CW,Ye W

更新日期：2014-01-01 00:00:00

abstract：:Cancer exosomes are gaining considerable amount of attention in basic and applied clinical research for their established role in the modulation of the tumor niche, and their broad-range contribution to tumor-host cross-talk. Supporting evidence to their role in tumorigenesis comes from the observation that exosome se...

journal_title：Cell adhesion & migration

authors： Fares J,Kashyap R,Zimmermann P

更新日期：2017-03-04 00:00:00