Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta.

abstract：:During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules ...

journal_title：Cell adhesion & migration

authors： Basu R,Taylor MR,Williams ME

更新日期：2015-01-01 00:00:00

abstract：:For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...

journal_title：Cell adhesion & migration

authors： Khanna A,Indracanti N,Chakrabarti R,Indraganti PK

更新日期：2020-12-01 00:00:00

abstract：:Eph signaling, which arises following stimulation by ephrins, is known to induce opposite cell behaviors such as promoting and inhibiting cell adhesion as well as promoting cell-cell adhesion and repulsion by altering the organization of the actin cytoskeleton and influencing the adhesion activities of integrins. Howe...

journal_title：Cell adhesion & migration

authors： Saeki N,Nishino S,Shimizu T,Ogawa K

更新日期：2015-01-01 00:00:00

abstract：:Optimising response to tyrosine kinase inhibitors in cancer remains an extensive field of research. Intravital imaging is an emerging tool, which can be used in drug discovery to facilitate and fine-tune maximum drug response in live tumors. A greater understanding of intratumoural delivery and pharmacodynamics of a d...

journal_title：Cell adhesion & migration

authors： Nobis M,McGhee EJ,Herrmann D,Magenau A,Morton JP,Anderson KI,Timpson P

更新日期：2014-01-01 00:00:00

abstract：:Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion form...

journal_title：Cell adhesion & migration

authors： Han SJ,Rodriguez ML,Al-Rekabi Z,Sniadecki NJ

更新日期：2016-09-02 00:00:00

abstract：:All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of...

journal_title：Cell adhesion & migration

authors： Mazzon C,Viola A

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to compare uniaxial traction forces exerted by different cell types using a novel sensor design and to test the dependence of measured forces on cytoskeletal integrity. The sensor design detects forces generated between 2 contact points by cells spanning a gap. The magnitude of these forces v...

journal_title：Cell adhesion & migration

authors： Swierczewski R,Hedley J,Redfern CP

更新日期：2016-05-03 00:00:00

abstract：:PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpr...

journal_title：Cell adhesion & migration

authors： Pang Y,Zhang Z,Wang Z,Wang Y,Yan Y,Li S,Tong H

更新日期：2019-12-01 00:00:00

abstract：:Tumor budding occurs at the invasive front of cancer; the tumor cells involved have metastatic and stemness features, indicating a poor prognosis. Tumor budding is partly responsible for cancer metastasis, and its initiation is based on the epithelial-mesenchymal transition (EMT) process. The EMT process involves the ...

journal_title：Cell adhesion & migration

authors： Li H,Xu F,Li S,Zhong A,Meng X,Lai M

更新日期：2016-07-03 00:00:00

abstract：:Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryoni...

journal_title：Cell adhesion & migration

authors： Smith CL,Tallquist MD

更新日期：2010-10-01 00:00:00

abstract：:Adhesion of epithelial cell to each other and to extracellular matrix, as well as cell migration ability and cytoskeleton organization undergo significant alterations in the course of neoplastic transformation, but regulatory mechanisms involved in these processes are not fully understood. Here, we studied the role of...

journal_title：Cell adhesion & migration

authors： Regev M,Sabanay H,Kartvelishvily E,Kam Z,Bershadsky AD

更新日期：2017-07-04 00:00:00

abstract：:Integrins regulate cell attachment and migration through interactions with specific proteins in the extra-cellular matrix. Heterotrimeric G proteins are essential signal transduction proteins that intersect with integrin signaling to regulate fundamental cellular behaviors. Although integrin and G protein signaling of...

journal_title：Cell adhesion & migration

authors： Kong T,Xu D,Tran M,Denker BM

更新日期：2010-07-01 00:00:00

abstract：:During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into the dorsal mantle layer after a 'waiting period' of a few days. We reve...

journal_title：Cell adhesion & migration

authors： Masuda T,Yaginuma H,Sakuma C,Ono K

更新日期：2009-04-01 00:00:00

abstract：:Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5...

journal_title：Cell adhesion & migration

authors： Spenlé C,Simon-Assmann P,Orend G,Miner JH

更新日期：2013-01-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in humans. They are involved in several inflammatory disorders, including the pathogenesis of inflammatory bowel disease (IBD). A recent paper showed that activated MAPK are upregulated on endothelium and fibroblasts from int...

journal_title：Cell adhesion & migration

authors： Scaldaferri F,Correale C,Gasbarrini A,Danese S

更新日期：2009-07-01 00:00:00

abstract：:Cellular motility is a fundamental process essential for embryonic development, wound healing, immune responses, and tissues development. Cells are mostly moving by crawling on external, or inside, substrates which can differ in their surface composition, geometry, and dimensionality. Cells can adopt different migrati...

journal_title：Cell adhesion & migration

authors： Siton-Mendelson O,Bernheim-Groswasser A

更新日期：2016-09-02 00:00:00

abstract：:Cancer exosomes are gaining considerable amount of attention in basic and applied clinical research for their established role in the modulation of the tumor niche, and their broad-range contribution to tumor-host cross-talk. Supporting evidence to their role in tumorigenesis comes from the observation that exosome se...

journal_title：Cell adhesion & migration

authors： Fares J,Kashyap R,Zimmermann P

更新日期：2017-03-04 00:00:00

abstract：:Neurodegenerative diseases have become a global issue due to the aging population. These disorders affect a vast patient population and represent a huge area of unmet therapeutic need. Axon degeneration is a common pathological character of those neurodegenerative diseases. It results in the loss of communication betw...

journal_title：Cell adhesion & migration

authors： Wang J,He Z

更新日期：2009-01-01 00:00:00

abstract：:The conserved polarity proteins Par6 and aPKC regulate cell polarization processes. However, increasing evidence also suggests that they play a role in oncogenic progression. During tumor progression, epithelial to mesenchymal transition (EMT) delineates an evolutionary conserved process that converts stationary epith...

journal_title：Cell adhesion & migration

authors： Gunaratne A,Di Guglielmo GM

更新日期：2013-07-01 00:00:00

abstract：:Anti-angiogenic vascular endothelial growth factor A (VEGF) 165b and pro-angiogenic VEGF 165 are generated from the same transcript, and their relative amounts are dependent on alternative splicing. The role of VEGF 165b has not been investigated in as much detail as VEGF 165, although it appears to be highly expresse...

journal_title：Cell adhesion & migration

authors： Peiris-Pagès M

更新日期：2012-11-01 00:00:00

abstract：:Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...

journal_title：Cell adhesion & migration

authors： La Gatta A,D'Agostino A,Schiraldi C,Colella G,Cirillo N

更新日期：2019-12-01 00:00:00

abstract：:Visceral adipose tissue (VAT) may play a critical role in atherosclerotic cardiovascular disease. The goal of this study was to determine the effect of human VAT-released pro‑inflammatory cytokines on monocyte adhesion to the endothelium. The cytokine effects on monocyte adhesion to the endothelial cells (ECs) were te...

journal_title：Cell adhesion & migration

authors： Cejkova S,Kubatova H,Thieme F,Janousek L,Fronek J,Poledne R,Kralova Lesna I

更新日期：2019-12-01 00:00:00

abstract：:Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adhesions in the cell....

journal_title：Cell adhesion & migration

authors： Bach CT,Schevzov G,Bryce NS,Gunning PW,O'Neill GM

更新日期：2010-04-01 00:00:00

abstract：:The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as prolife...

journal_title：Cell adhesion & migration

authors： Horimoto Y,Polanska UM,Takahashi Y,Orimo A

更新日期：2012-05-01 00:00:00

abstract：:ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa GTPase with homology to Ras. Re-expression of ARHI inhibits ovarian cancer growth, initiates autophagy and induces tumor dormancy. Recent studies have...

journal_title：Cell adhesion & migration

authors： Lu Z,Bast RC Jr

更新日期：2013-03-01 00:00:00

abstract：:It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus wh...

journal_title：Cell adhesion & migration

authors： van den Berg MC,Burgering BM

更新日期：2014-01-01 00:00:00

abstract：:The class-specific transcription factors Knot and Cut act during dendrite arbor development to define the characteristic dendrite branching pattern of the Drosophila class IV dendritic arborisation sensory neurons. Knot mediates dendrite arbor outgrowth and branching via a microtubule-based program that includes upreg...

journal_title：Cell adhesion & migration

authors： Moore AW

更新日期：2008-04-01 00:00:00

abstract：:The hypotheses emerging from basic research on colorectal liver metastases must be tested in clinical situations for the adaptation of current treatment strategies. Pre-metastatic niches have been shown to exist in human colorectal synchronous metastases, with the liver parenchyma adjacent to the synchronous liver met...

journal_title：Cell adhesion & migration

authors： Eveno C,Pocard M

更新日期：2012-11-01 00:00:00

abstract：:In the cortex of a motile cell, membrane-anchored actin filaments assemble into structures of varying shape and function. Filopodia are distinguished by a core of bundled actin filaments within finger-like extensions of the membrane. In a recent paper by Medalia et al(1) cryo-electron tomography has been used to recon...

journal_title：Cell adhesion & migration

authors： Gerisch G,Weber I

更新日期：2007-07-01 00:00:00

abstract：:In this article, I discuss the hallmarks of hypoxia in vitro and in vivo and review work showing that many types of stem cell proliferate more robustly in lowered oxygen. I then discuss recent studies showing that alterations in the levels and the types of cell and substrate adhesion molecules are a notable response t...

journal_title：Cell adhesion & migration

authors： Crossin KL

更新日期：2012-01-01 00:00:00