Abstract:
:Tumor budding occurs at the invasive front of cancer; the tumor cells involved have metastatic and stemness features, indicating a poor prognosis. Tumor budding is partly responsible for cancer metastasis, and its initiation is based on the epithelial-mesenchymal transition (EMT) process. The EMT process involves the conversion of epithelial cells into migratory and invasive cells, and is a profound event in tumorigenesis. The EMT, associated with the formation of cancer stem cells (CSCs) and resistance to therapy, results from a combination of gene mutation, epigenetic regulation, and microenvironmental control. Tumor budding can be taken to represent the EMT in vivo. The EMT process is under the influence of the tumor microenvironment as well as tumor cells themselves. Here, we demonstrate that the tumor microenvironment dominates EMT development and impacts cancer metastasis, as well as promotes CSC formation and mediates drug resistance. In this review, we mainly discuss components of the microenvironment, such as the extracellular matrix (ECM), inflammatory cytokines, metabolic products, and hypoxia, that are involved in and impact on the acquisition of tumor-cell motility and dissemination, the EMT, metastatic tumor-cell formation, tumor budding and CSCs, and cancer metastasis, including subsequent chemo-resistance. From our point of view, the tumor microenvironment now constitutes a promising target for cancer therapy.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Li H,Xu F,Li S,Zhong A,Meng X,Lai Mdoi
10.1080/19336918.2015.1129481subject
Has Abstractpub_date
2016-07-03 00:00:00pages
434-46issue
4eissn
1933-6918issn
1933-6926journal_volume
10pub_type
杂志文章,评审abstract::Integrins regulate cell attachment and migration through interactions with specific proteins in the extra-cellular matrix. Heterotrimeric G proteins are essential signal transduction proteins that intersect with integrin signaling to regulate fundamental cellular behaviors. Although integrin and G protein signaling of...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.3.11639
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abstract::All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:
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abstract::An expanding body of evidence demonstrates that cells undergoing apoptosis send out a selection of molecular navigational signals including proteins, lipids and nucleotides that serve to recruit phagocytes to the dying targets which are subsequently engulfed and removed. This homeostatic process is essentially non-phl...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.5.4.16743
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
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doi:10.1080/19336918.2016.1225633
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.4.9581
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/19336918.2014.970004
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1183867
更新日期:2017-01-02 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.4.9451
更新日期:2009-10-01 00:00:00
abstract::When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn dete...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1083667
更新日期:2016-03-03 00:00:00
abstract::Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryoni...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.4.4.12829
更新日期:2010-10-01 00:00:00
abstract::The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2017.1405208
更新日期:2018-01-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.4.8604
更新日期:2009-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1173800
更新日期:2016-09-02 00:00:00
abstract::The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1093275
更新日期:2016-03-03 00:00:00
abstract::Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are assoc...
journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:Cell adhesion & migration
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更新日期:2013-09-01 00:00:00
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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更新日期:2018-03-04 00:00:00
abstract::The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p5...
journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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