Navigating the cell: UNC-53 and the navigators, a family of cytoskeletal regulators with multiple roles in cell migration, outgrowth and trafficking.

abstract：:Eph signaling, which arises following stimulation by ephrins, is known to induce opposite cell behaviors such as promoting and inhibiting cell adhesion as well as promoting cell-cell adhesion and repulsion by altering the organization of the actin cytoskeleton and influencing the adhesion activities of integrins. Howe...

journal_title：Cell adhesion & migration

authors： Saeki N,Nishino S,Shimizu T,Ogawa K

更新日期：2015-01-01 00:00:00

abstract：:Cell surface receptors of the integrin family are pivotal to cell adhesion and migration. The activation state of heterodimeric alphabeta integrins is correlated to the association state of the single-pass alpha and beta transmembrane domains. The association of integrin alphaIIbbeta3 transmembrane domains, resulting ...

journal_title：Cell adhesion & migration

authors： Ulmer TS

更新日期：2010-04-01 00:00:00

abstract：:The proper establishment and organogenesis of the placenta is crucial for intrauterine fetal growth and development. Endometrial invasion by the extravillous trophoblast cells, as well as formation of the syncytiotrophoblast (STB), are of vital importance for placental function. Trophoblast migration and invasion is o...

journal_title：Cell adhesion & migration

authors： Kohan-Ghadr HR,Kadam L,Jain C,Armant DR,Drewlo S

更新日期：2016-03-03 00:00:00

abstract：:Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-th...

journal_title：Cell adhesion & migration

authors： Dumbauld DW,García AJ

更新日期：2014-01-01 00:00:00

abstract：:Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This m...

journal_title：Cell adhesion & migration

authors： Gupta M,Doss B,Lim CT,Voituriez R,Ladoux B

更新日期：2016-09-02 00:00:00

abstract：:The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with...

journal_title：Cell adhesion & migration

authors： Candelier JJ

更新日期：2016-03-03 00:00:00

abstract：:The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences i...

journal_title：Cell adhesion & migration

authors： Fagotto F,Winklbauer R,Rohani N

更新日期：2014-01-01 00:00:00

abstract：:For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...

journal_title：Cell adhesion & migration

authors： Khanna A,Indracanti N,Chakrabarti R,Indraganti PK

更新日期：2020-12-01 00:00:00

abstract：:Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5...

journal_title：Cell adhesion & migration

authors： Spenlé C,Simon-Assmann P,Orend G,Miner JH

更新日期：2013-01-01 00:00:00

abstract：:Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support...

journal_title：Cell adhesion & migration

authors： Arregui CO,González Á,Burdisso JE,González Wusener AE

更新日期：2013-09-01 00:00:00

abstract：:During an infection, neutrophils are the first immune cells to arrive armed to clear the invading pathogen. In order to do so, neutrophils need to transmigrate from the peripheral blood through the endothelial layer toward the site of inflammation. This process is in most cases dependent on integrins, adhesion molecul...

journal_title：Cell adhesion & migration

authors： Langereis JD

更新日期：2013-11-01 00:00:00

abstract：:During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into the dorsal mantle layer after a 'waiting period' of a few days. We reve...

journal_title：Cell adhesion & migration

authors： Masuda T,Yaginuma H,Sakuma C,Ono K

更新日期：2009-04-01 00:00:00

abstract：:The goal of this review is to highlight how emerging new models of filopodia assembly, which include tissue specific actin-bundling proteins, could provide more comprehensive representations of filopodia assembly that would describe more adequately and effectively the complexity and plasticity of epithelial cells.  Th...

journal_title：Cell adhesion & migration

authors： Khurana S,George SP

更新日期：2011-09-01 00:00:00

abstract：:It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus wh...

journal_title：Cell adhesion & migration

authors： van den Berg MC,Burgering BM

更新日期：2014-01-01 00:00:00

abstract：:The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces ...

journal_title：Cell adhesion & migration

authors： Anderson NR,Buffone A Jr,Hammer DA

更新日期：2019-12-01 00:00:00

abstract：:The actin cytoskeleton plays a key role in regulating cell motility. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells that is conserved among a variety of vertebrates. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (...

journal_title：Cell adhesion & migration

authors： Mayanagi T,Sobue K

更新日期：2011-03-01 00:00:00

abstract：:Optimising response to tyrosine kinase inhibitors in cancer remains an extensive field of research. Intravital imaging is an emerging tool, which can be used in drug discovery to facilitate and fine-tune maximum drug response in live tumors. A greater understanding of intratumoural delivery and pharmacodynamics of a d...

journal_title：Cell adhesion & migration

authors： Nobis M,McGhee EJ,Herrmann D,Magenau A,Morton JP,Anderson KI,Timpson P

更新日期：2014-01-01 00:00:00

abstract：:Directional cell migration requires cell polarization and asymmetric distribution of cell signaling. Focal adhesions and microtubules are two systems which are essential for these. It was shown that these two systems closely interact with each other. It is known that microtubule targeting stimulates focal adhesion dis...

journal_title：Cell adhesion & migration

authors： Efimov A,Kaverina I

更新日期：2009-07-01 00:00:00

abstract：:Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion form...

journal_title：Cell adhesion & migration

authors： Han SJ,Rodriguez ML,Al-Rekabi Z,Sniadecki NJ

更新日期：2016-09-02 00:00:00

abstract：:The class-specific transcription factors Knot and Cut act during dendrite arbor development to define the characteristic dendrite branching pattern of the Drosophila class IV dendritic arborisation sensory neurons. Knot mediates dendrite arbor outgrowth and branching via a microtubule-based program that includes upreg...

journal_title：Cell adhesion & migration

authors： Moore AW

更新日期：2008-04-01 00:00:00

abstract：:An expanding body of evidence demonstrates that cells undergoing apoptosis send out a selection of molecular navigational signals including proteins, lipids and nucleotides that serve to recruit phagocytes to the dying targets which are subsequently engulfed and removed. This homeostatic process is essentially non-phl...

journal_title：Cell adhesion & migration

authors： Gregory CD,Rossi AG,Bournazou I,Zhuang L,Willems JJ

更新日期：2011-07-01 00:00:00

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in the cerebrospinal fluid. Nevertheless, its role in the central nervous system is far from clear. Here, we present evidence that L-PGDS induces glial cell migration and morphological changes in vitro and in vivo. We also identified...

journal_title：Cell adhesion & migration

authors： Suk K

更新日期：2012-05-01 00:00:00

abstract：:Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...

journal_title：Cell adhesion & migration

authors： La Gatta A,D'Agostino A,Schiraldi C,Colella G,Cirillo N

更新日期：2019-12-01 00:00:00

abstract：:Normal vascular development and angiogenesis is regulated by coordinated changes in cell-cell and cell-extracellular matrix (ECM) interactions. The Homeobox (Hox) family of transcription factors coordinately regulate expression of matrix degrading proteinases, integrins and ECM components and profoundly impact vascula...

journal_title：Cell adhesion & migration

authors： Arderiu G,Cuevas I,Chen A,Carrio M,East L,Boudreau NJ

更新日期：2007-10-01 00:00:00

abstract：:PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpr...

journal_title：Cell adhesion & migration

authors： Pang Y,Zhang Z,Wang Z,Wang Y,Yan Y,Li S,Tong H

更新日期：2019-12-01 00:00:00

abstract：:Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are assoc...

journal_title：Cell adhesion & migration

authors： van den Dries K,Bolomini-Vittori M,Cambi A

更新日期：2014-01-01 00:00:00

abstract：:It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...

journal_title：Cell adhesion & migration

authors： Krull CE

更新日期：2010-10-01 00:00:00

abstract：:Integrins regulate cell attachment and migration through interactions with specific proteins in the extra-cellular matrix. Heterotrimeric G proteins are essential signal transduction proteins that intersect with integrin signaling to regulate fundamental cellular behaviors. Although integrin and G protein signaling of...

journal_title：Cell adhesion & migration

authors： Kong T,Xu D,Tran M,Denker BM

更新日期：2010-07-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the third most frequent malignancy within urological oncology. However, the mechanisms responsible for RCC metastasis are still needed further illustration. Our present study revealed that a seven-transmembrane receptor G-protein coupled estrogen receptor (GPER) was highly detected in var...

journal_title：Cell adhesion & migration

authors： Guan BZ,Yan RL,Huang JW,Li FL,Zhong YX,Chen Y,Liu FN,Hu B,Huang SB,Yin LH

更新日期：2018-03-04 00:00:00

abstract：:A deterministic model of dermal wound invasion, which accounts for the platelet-derived growth factor (PDGF) gradient sensing mechanism in fibroblasts mediated by cell surface receptors and the phosphoinositide 3-kinase (PI3K) signal transduction pathway, was previously described (Biophys J 2006; 90:2297-308). Here, w...

journal_title：Cell adhesion & migration

authors： Monine MI,Haugh JM

更新日期：2008-04-01 00:00:00