Abstract:
:Cell surface receptors of the integrin family are pivotal to cell adhesion and migration. The activation state of heterodimeric alphabeta integrins is correlated to the association state of the single-pass alpha and beta transmembrane domains. The association of integrin alphaIIbbeta3 transmembrane domains, resulting in an inactive receptor, is characterized by the asymmetric arrangement of a straight (alphaIIb) and tilted (beta3) helix relative to the membrane in congruence to the dissociated structures. This allows for a continuous association interface centered on helix-helix glycine-packing and an unusual alphaIIb(GFF) structural motif that packs the conserved Phe-Phe residues against the beta3 transmembrane helix, enabling alphaIIb(D723)beta3(R995) electrostatic interactions. The transmembrane complex is further stabilized by the inactive ectodomain, thereby coupling its association state to the ectodomain conformation. In combination with recently determined structures of an inactive integrin ectodomain and an activating talin/beta complex that overlap with the alphabeta transmembrane complex, a comprehensive picture of integrin bi-directional transmembrane signaling has emerged.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Ulmer TSdoi
10.4161/cam.4.2.10592subject
Has Abstractpub_date
2010-04-01 00:00:00pages
243-8issue
2eissn
1933-6918issn
1933-6926pii
10592journal_volume
4pub_type
杂志文章abstract::During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into the dorsal mantle layer after a 'waiting period' of a few days. We reve...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.2.7837
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1225632
更新日期:2017-03-04 00:00:00
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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