Abstract:
:There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources such as allogeneic umbilical cord-derived cells may provide a more accessible and practical supply of cells for transplantation. In this case report we present the treatment of aggressive multiple sclerosis with multiple allogenic human umbilical cord-derived mesenchymal stem cell and autologous bone marrow-derived mesenchymal stem cells over a 4 y period. The treatments were tolerated well with no significant adverse events. Clinical and radiological disease appeared to be suppressed following the treatments and support the expansion of mesenchymal stem cell transplantation into clinical trials as a potential novel therapy for patients with aggressive multiple sclerosis.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Hou ZL,Liu Y,Mao XH,Wei CY,Meng MY,Liu YH,Zhuyun Yang Z,Zhu H,Short M,Bernard C,Xiao ZCdoi
10.4161/cam.26941subject
Has Abstractpub_date
2013-09-01 00:00:00pages
404-7issue
5eissn
1933-6918issn
1933-6926pii
26941journal_volume
7pub_type
杂志文章abstract::Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell. Recent findings implicate cyc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.3.11131
更新日期:2010-07-01 00:00:00
abstract::Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1120397
更新日期:2016-03-03 00:00:00
abstract::PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2019.1619434
更新日期:2019-12-01 00:00:00
abstract::The mechanical and structural properties of the extracellular matrix (ECM) play an important role in regulating cell fate. The natural ECM has a complex fibrillar structure and shows nonlinear mechanical properties, which are both difficult to mimic synthetically. Therefore, systematically testing the influence of ECM...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1151607
更新日期:2016-09-02 00:00:00
abstract::During an infection, neutrophils are the first immune cells to arrive armed to clear the invading pathogen. In order to do so, neutrophils need to transmigrate from the peripheral blood through the endothelial layer toward the site of inflammation. This process is in most cases dependent on integrins, adhesion molecul...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.27293
更新日期:2013-11-01 00:00:00
abstract::Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2018.1494997
更新日期:2019-12-01 00:00:00
abstract::ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa GTPase with homology to Ras. Re-expression of ARHI inhibits ovarian cancer growth, initiates autophagy and induces tumor dormancy. Recent studies have...
journal_title:Cell adhesion & migration
pub_type: 评论,杂志文章
doi:10.4161/cam.23648
更新日期:2013-03-01 00:00:00
abstract::Visceral adipose tissue (VAT) may play a critical role in atherosclerotic cardiovascular disease. The goal of this study was to determine the effect of human VAT-released pro‑inflammatory cytokines on monocyte adhesion to the endothelium. The cytokine effects on monocyte adhesion to the endothelial cells (ECs) were te...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2019.1644856
更新日期:2019-12-01 00:00:00
abstract::All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This m...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1173800
更新日期:2016-09-02 00:00:00
abstract::The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as prolife...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.20631
更新日期:2012-05-01 00:00:00
abstract::Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell adhesion by linking transmembrane proteins to the actin cytoskeleton. Additionally, they participate in recruitment of signaling recept...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21326
更新日期:2012-07-01 00:00:00
abstract::For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2020.1842131
更新日期:2020-12-01 00:00:00
abstract::Spinal cord injury (SCI) has been regarded clinically as an irreversible damage caused by tissue contusion due to a blunt external force. Past research had focused on the analysis of the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as tissue damage and neural cell d...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.1.7372
更新日期:2009-01-01 00:00:00
abstract::Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2018.1491234
更新日期:2019-12-01 00:00:00
abstract::Cancer exosomes are gaining considerable amount of attention in basic and applied clinical research for their established role in the modulation of the tumor niche, and their broad-range contribution to tumor-host cross-talk. Supporting evidence to their role in tumorigenesis comes from the observation that exosome se...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1225632
更新日期:2017-03-04 00:00:00
abstract::Eph receptors and their membrane-bound ligands are intimately involved in the control of morphogenic processes during embryonic development and adult tissue homeostasis. By their ability to orchestrate cell migration, pattern formation and tissue integrity they are also prone to be involved in carcinogenic growth. In ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.20154
更新日期:2012-03-01 00:00:00
abstract::It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.4.4.13594
更新日期:2010-10-01 00:00:00
abstract::The term polarity refers to the differential distribution of the macromolecular elements of a cell, resulting in its asymmetry in function, shape and/or content. Polarity is a fundamental property of all metazoan cells in at least some stages, and is pivotal to processes such as epithelial differentiation (apical/basa...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.1.2.4547
更新日期:2007-04-01 00:00:00
abstract::Physical cues from the extracellular environment that influence cell shape and directional migration are transduced into changes in cytoskeletal organization and biochemistry through integrin-based cell adhesions to extracellular matrix (ECM). Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin a...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.21672
更新日期:2012-11-01 00:00:00
abstract::During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2014.1000072
更新日期:2015-01-01 00:00:00
abstract::The conserved polarity proteins Par6 and aPKC regulate cell polarization processes. However, increasing evidence also suggests that they play a role in oncogenic progression. During tumor progression, epithelial to mesenchymal transition (EMT) delineates an evolutionary conserved process that converts stationary epith...
journal_title:Cell adhesion & migration
pub_type: 评论,杂志文章
doi:10.4161/cam.25651
更新日期:2013-07-01 00:00:00
abstract::Directional cell migration requires cell polarization and asymmetric distribution of cell signaling. Focal adhesions and microtubules are two systems which are essential for these. It was shown that these two systems closely interact with each other. It is known that microtubule targeting stimulates focal adhesion dis...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.3.8858
更新日期:2009-07-01 00:00:00
abstract::Cellular studies have long been performed on the bench top, within Petri dishes and flasks that expose cells to surroundings that differ greatly from their native environment. The complexity of a human tissue is such that to truly replicate a cell's physiologic microenvironment in vitro is currently impossible. It is ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21076
更新日期:2012-05-01 00:00:00
abstract::Galectin-1 (gal-1), a member of the mammalian β-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation. In previous studies, we demonstrated that gal-1 induces cell differentiation processes on the membrane of choriocarc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1089377
更新日期:2016-03-03 00:00:00
abstract::Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryoni...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.4.4.12829
更新日期:2010-10-01 00:00:00
abstract::In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions charact...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.23130
更新日期:2013-03-01 00:00:00
abstract::Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in humans. They are involved in several inflammatory disorders, including the pathogenesis of inflammatory bowel disease (IBD). A recent paper showed that activated MAPK are upregulated on endothelium and fibroblasts from int...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.3.9152
更新日期:2009-07-01 00:00:00
abstract::The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences i...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/19336918.2014.970028
更新日期:2014-01-01 00:00:00
abstract::When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn dete...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1083667
更新日期:2016-03-03 00:00:00