Membrane tubulovesicular extensions (cytonemes): secretory and adhesive cellular organelles.

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in the cerebrospinal fluid. Nevertheless, its role in the central nervous system is far from clear. Here, we present evidence that L-PGDS induces glial cell migration and morphological changes in vitro and in vivo. We also identified...

journal_title：Cell adhesion & migration

authors： Suk K

更新日期：2012-05-01 00:00:00

abstract：:Normal vascular development and angiogenesis is regulated by coordinated changes in cell-cell and cell-extracellular matrix (ECM) interactions. The Homeobox (Hox) family of transcription factors coordinately regulate expression of matrix degrading proteinases, integrins and ECM components and profoundly impact vascula...

journal_title：Cell adhesion & migration

authors： Arderiu G,Cuevas I,Chen A,Carrio M,East L,Boudreau NJ

更新日期：2007-10-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in humans. They are involved in several inflammatory disorders, including the pathogenesis of inflammatory bowel disease (IBD). A recent paper showed that activated MAPK are upregulated on endothelium and fibroblasts from int...

journal_title：Cell adhesion & migration

authors： Scaldaferri F,Correale C,Gasbarrini A,Danese S

更新日期：2009-07-01 00:00:00

abstract：:Eph signaling, which arises following stimulation by ephrins, is known to induce opposite cell behaviors such as promoting and inhibiting cell adhesion as well as promoting cell-cell adhesion and repulsion by altering the organization of the actin cytoskeleton and influencing the adhesion activities of integrins. Howe...

journal_title：Cell adhesion & migration

authors： Saeki N,Nishino S,Shimizu T,Ogawa K

更新日期：2015-01-01 00:00:00

abstract：:During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules ...

journal_title：Cell adhesion & migration

authors： Basu R,Taylor MR,Williams ME

更新日期：2015-01-01 00:00:00

abstract：:Over 20 years ago, protrusive, F-actin-based membrane structures, termed invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia penetrate artificial or explanted extracellular matrices in 2D culture conditions and have been hypothesized to facilitate the migration of cancer cells through base...

journal_title：Cell adhesion & migration

authors： Lohmer LL,Kelley LC,Hagedorn EJ,Sherwood DR

更新日期：2014-01-01 00:00:00

abstract：:Integrins regulate cell attachment and migration through interactions with specific proteins in the extra-cellular matrix. Heterotrimeric G proteins are essential signal transduction proteins that intersect with integrin signaling to regulate fundamental cellular behaviors. Although integrin and G protein signaling of...

journal_title：Cell adhesion & migration

authors： Kong T,Xu D,Tran M,Denker BM

更新日期：2010-07-01 00:00:00

abstract：:For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...

journal_title：Cell adhesion & migration

authors： Khanna A,Indracanti N,Chakrabarti R,Indraganti PK

更新日期：2020-12-01 00:00:00

abstract：:Although epithelial to mesenchymal transitions (EMT) are often viewed as a unique event, they are characterized by a great diversity of cellular processes resulting in strikingly different outcomes. They may be complete or partial, massive or progressive, and lead to the complete disruption of the epithelium or leave ...

journal_title：Cell adhesion & migration

authors： Duband JL

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tum...

journal_title：Cell adhesion & migration

authors： Hohmann T,Grabiec U,Ghadban C,Feese K,Dehghani F

更新日期：2017-01-02 00:00:00

abstract：:Extensive research efforts have been conducted over the past decades to understand the processing of the Amyloid Precursor Protein (APP). APP cleavage leads to the production of the beta-amyloid peptide (Abeta), which is the major constituent of the amyloid core of senile plaques found in the brains of patients with A...

journal_title：Cell adhesion & migration

authors： Khalifa NB,Van Hees J,Tasiaux B,Huysseune S,Smith SO,Constantinescu SN,Octave JN,Kienlen-Campard P

更新日期：2010-04-01 00:00:00

abstract：:Galectin-1 (gal-1), a member of the mammalian β-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation. In previous studies, we demonstrated that gal-1 induces cell differentiation processes on the membrane of choriocarc...

journal_title：Cell adhesion & migration

authors： Hutter S,Morales-Prieto DM,Andergassen U,Tschakert L,Kuhn C,Hofmann S,Markert UR,Jeschke U

更新日期：2016-03-03 00:00:00

abstract：:The proper establishment and organogenesis of the placenta is crucial for intrauterine fetal growth and development. Endometrial invasion by the extravillous trophoblast cells, as well as formation of the syncytiotrophoblast (STB), are of vital importance for placental function. Trophoblast migration and invasion is o...

journal_title：Cell adhesion & migration

authors： Kohan-Ghadr HR,Kadam L,Jain C,Armant DR,Drewlo S

更新日期：2016-03-03 00:00:00

abstract：:The actin cytoskeleton plays a key role in regulating cell motility. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells that is conserved among a variety of vertebrates. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (...

journal_title：Cell adhesion & migration

authors： Mayanagi T,Sobue K

更新日期：2011-03-01 00:00:00

abstract：:In addition to its well-defined role as an antagonist in apoptosis, we propose that BCL2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. Our evidence shows that, when over-expressed in both cancer and non-cancer cells, BCL2 can form a complex with actin and gelsolin that ...

journal_title：Cell adhesion & migration

authors： Ke H,Zhang JY,Akiyama SK,French JE

更新日期：2011-01-01 00:00:00

abstract：:Eph receptors and their membrane-bound ligands are intimately involved in the control of morphogenic processes during embryonic development and adult tissue homeostasis. By their ability to orchestrate cell migration, pattern formation and tissue integrity they are also prone to be involved in carcinogenic growth. In ...

journal_title：Cell adhesion & migration

authors： Kaenel P,Mosimann M,Andres AC

更新日期：2012-03-01 00:00:00

abstract：:The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences i...

journal_title：Cell adhesion & migration

authors： Fagotto F,Winklbauer R,Rohani N

更新日期：2014-01-01 00:00:00

abstract：:The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p5...

journal_title：Cell adhesion & migration

authors： Mak AS

更新日期：2011-03-01 00:00:00

abstract：:Changes in cell shape are associated with a variety of processes including cell migration, axon outgrowth, cell division and vesicle trafficking. C. elegans UNC-53 and its vertebrate homologs, the Navigators, are required for the migration of cells and the outgrowth of neuronal processes. The identification of novel m...

journal_title：Cell adhesion & migration

authors： Stringham EG,Schmidt KL

更新日期：2009-10-01 00:00:00

abstract：:Adhesion of epithelial cell to each other and to extracellular matrix, as well as cell migration ability and cytoskeleton organization undergo significant alterations in the course of neoplastic transformation, but regulatory mechanisms involved in these processes are not fully understood. Here, we studied the role of...

journal_title：Cell adhesion & migration

authors： Regev M,Sabanay H,Kartvelishvily E,Kam Z,Bershadsky AD

更新日期：2017-07-04 00:00:00

abstract：:Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell. Recent findings implicate cyc...

journal_title：Cell adhesion & migration

authors： Tripathi BK,Zelenka PS

更新日期：2010-07-01 00:00:00

abstract：:Neurodegenerative diseases have become a global issue due to the aging population. These disorders affect a vast patient population and represent a huge area of unmet therapeutic need. Axon degeneration is a common pathological character of those neurodegenerative diseases. It results in the loss of communication betw...

journal_title：Cell adhesion & migration

authors： Wang J,He Z

更新日期：2009-01-01 00:00:00

abstract：:Directional cell migration is essential for almost all organisms during embryonic development, in adult life and contributes to pathological conditions. This is particularly critical during embryogenesis where it is essential that cells end up in their correct, precise locations in order to build a normal embryo. Many...

journal_title：Cell adhesion & migration

authors： Carmona-Fontaine C,Matthews H,Mayor R

更新日期：2008-10-01 00:00:00

abstract：:It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus wh...

journal_title：Cell adhesion & migration

authors： van den Berg MC,Burgering BM

更新日期：2014-01-01 00:00:00

abstract：:A deterministic model of dermal wound invasion, which accounts for the platelet-derived growth factor (PDGF) gradient sensing mechanism in fibroblasts mediated by cell surface receptors and the phosphoinositide 3-kinase (PI3K) signal transduction pathway, was previously described (Biophys J 2006; 90:2297-308). Here, w...

journal_title：Cell adhesion & migration

authors： Monine MI,Haugh JM

更新日期：2008-04-01 00:00:00

abstract：:Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adhesions in the cell....

journal_title：Cell adhesion & migration

authors： Bach CT,Schevzov G,Bryce NS,Gunning PW,O'Neill GM

更新日期：2010-04-01 00:00:00

abstract：:Tumor budding occurs at the invasive front of cancer; the tumor cells involved have metastatic and stemness features, indicating a poor prognosis. Tumor budding is partly responsible for cancer metastasis, and its initiation is based on the epithelial-mesenchymal transition (EMT) process. The EMT process involves the ...

journal_title：Cell adhesion & migration

authors： Li H,Xu F,Li S,Zhong A,Meng X,Lai M

更新日期：2016-07-03 00:00:00

abstract：:Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds...

journal_title：Cell adhesion & migration

authors： Arriagada C,Silva P,Torres VA

更新日期：2019-12-01 00:00:00

abstract：:Monocyte-extracellular matrix interactions have been implicated in atherosclerosis pathophysiology. Laminin, the main basement membrane protein contains cell binding domains that can be cryptic, presented only after protein modification. In the present study we evaluated monocyte attachment to laminin-1 in the presenc...

journal_title：Cell adhesion & migration

authors： Kostidou E,Trachana V,Topouridou K,Paletas K,Tsapas A,Kaloyianni M,Koliakos G

更新日期：2009-04-01 00:00:00

abstract：:The term polarity refers to the differential distribution of the macromolecular elements of a cell, resulting in its asymmetry in function, shape and/or content. Polarity is a fundamental property of all metazoan cells in at least some stages, and is pivotal to processes such as epithelial differentiation (apical/basa...

journal_title：Cell adhesion & migration

authors： Gómez-Moutón C,Mañes S

更新日期：2007-04-01 00:00:00