The multifaceted roles of Eph/ephrin signaling in breast cancer.

abstract：:The conserved polarity proteins Par6 and aPKC regulate cell polarization processes. However, increasing evidence also suggests that they play a role in oncogenic progression. During tumor progression, epithelial to mesenchymal transition (EMT) delineates an evolutionary conserved process that converts stationary epith...

journal_title：Cell adhesion & migration

authors： Gunaratne A,Di Guglielmo GM

更新日期：2013-07-01 00:00:00

abstract：:Since the time it was pioneered in 1992, intravital imaging of tumors at cellular resolution has offered us the extremely important opportunity of "seeing biology." However, until now, most studies were monitoring tumor cell behavior in the same animal over short times, requiring the combining of acquired data into a ...

journal_title：Cell adhesion & migration

authors： Gligorijevic B,Condeelis J

更新日期：2009-10-01 00:00:00

abstract：:Eph signaling, which arises following stimulation by ephrins, is known to induce opposite cell behaviors such as promoting and inhibiting cell adhesion as well as promoting cell-cell adhesion and repulsion by altering the organization of the actin cytoskeleton and influencing the adhesion activities of integrins. Howe...

journal_title：Cell adhesion & migration

authors： Saeki N,Nishino S,Shimizu T,Ogawa K

更新日期：2015-01-01 00:00:00

abstract：:When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn dete...

journal_title：Cell adhesion & migration

authors： James J,Tun W,Clark A

更新日期：2016-03-03 00:00:00

abstract：:Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This m...

journal_title：Cell adhesion & migration

authors： Gupta M,Doss B,Lim CT,Voituriez R,Ladoux B

更新日期：2016-09-02 00:00:00

abstract：:In addition to its well-defined role as an antagonist in apoptosis, we propose that BCL2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. Our evidence shows that, when over-expressed in both cancer and non-cancer cells, BCL2 can form a complex with actin and gelsolin that ...

journal_title：Cell adhesion & migration

authors： Ke H,Zhang JY,Akiyama SK,French JE

更新日期：2011-01-01 00:00:00

abstract：:The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with...

journal_title：Cell adhesion & migration

authors： Candelier JJ

更新日期：2016-03-03 00:00:00

abstract：:The goal of this review is to highlight how emerging new models of filopodia assembly, which include tissue specific actin-bundling proteins, could provide more comprehensive representations of filopodia assembly that would describe more adequately and effectively the complexity and plasticity of epithelial cells.  Th...

journal_title：Cell adhesion & migration

authors： Khurana S,George SP

更新日期：2011-09-01 00:00:00

abstract：:Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...

journal_title：Cell adhesion & migration

authors： Silva JF,Serakides R

更新日期：2016-03-03 00:00:00

abstract：:Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support...

journal_title：Cell adhesion & migration

authors： Arregui CO,González Á,Burdisso JE,González Wusener AE

更新日期：2013-09-01 00:00:00

abstract：:During an infection, neutrophils are the first immune cells to arrive armed to clear the invading pathogen. In order to do so, neutrophils need to transmigrate from the peripheral blood through the endothelial layer toward the site of inflammation. This process is in most cases dependent on integrins, adhesion molecul...

journal_title：Cell adhesion & migration

authors： Langereis JD

更新日期：2013-11-01 00:00:00

abstract：:Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are assoc...

journal_title：Cell adhesion & migration

authors： van den Dries K,Bolomini-Vittori M,Cambi A

更新日期：2014-01-01 00:00:00

abstract：:An expanding body of evidence demonstrates that cells undergoing apoptosis send out a selection of molecular navigational signals including proteins, lipids and nucleotides that serve to recruit phagocytes to the dying targets which are subsequently engulfed and removed. This homeostatic process is essentially non-phl...

journal_title：Cell adhesion & migration

authors： Gregory CD,Rossi AG,Bournazou I,Zhuang L,Willems JJ

更新日期：2011-07-01 00:00:00

abstract：:Physical cues from the extracellular environment that influence cell shape and directional migration are transduced into changes in cytoskeletal organization and biochemistry through integrin-based cell adhesions to extracellular matrix (ECM). Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin a...

journal_title：Cell adhesion & migration

authors： Sero JE,German AE,Mammoto A,Ingber DE

更新日期：2012-11-01 00:00:00

abstract：:Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...

journal_title：Cell adhesion & migration

authors： La Gatta A,D'Agostino A,Schiraldi C,Colella G,Cirillo N

更新日期：2019-12-01 00:00:00

abstract：:In this article, I discuss the hallmarks of hypoxia in vitro and in vivo and review work showing that many types of stem cell proliferate more robustly in lowered oxygen. I then discuss recent studies showing that alterations in the levels and the types of cell and substrate adhesion molecules are a notable response t...

journal_title：Cell adhesion & migration

authors： Crossin KL

更新日期：2012-01-01 00:00:00

abstract：:Discoidin domain receptors 1 and 2 (DDR1 and DDR2) are members of the tyrosine kinase receptors activated after binding with collagen. DDRs are implicated in numerous physiological and pathological functions such as proliferation, adhesion and migration. Little is known about the expression of the two receptors in nor...

journal_title：Cell adhesion & migration

authors： Croissant C,Tuariihionoa A,Bacou M,Souleyreau W,Sala M,Henriet E,Bikfalvi A,Saltel F,Auguste P

更新日期：2018-01-01 00:00:00

abstract：:Although epithelial to mesenchymal transitions (EMT) are often viewed as a unique event, they are characterized by a great diversity of cellular processes resulting in strikingly different outcomes. They may be complete or partial, massive or progressive, and lead to the complete disruption of the epithelium or leave ...

journal_title：Cell adhesion & migration

authors： Duband JL

更新日期：2010-07-01 00:00:00

abstract：:Adult stem cells generally reside in supporting local micro environments or niches, and intimate stem cell and niche association is critical for their long-term maintenance and function. Recent studies in model organisms especially Drosophila have started to unveil the underlying mechanisms of stem anchorage in the ni...

journal_title：Cell adhesion & migration

authors： Xi R

更新日期：2009-10-01 00:00:00

abstract：:The micro-environment of cancer cells in the body is mechanically stiffer than that of normal cells. We cultured three breast cell lines of MCF10A-normal, MCF7-noninvasive, and MDA-MB-231-invasive on PDMS substrates with different elastic moduli and different cellular features were examined.Effects of substrate stiffn...

journal_title：Cell adhesion & migration

authors： Ansardamavandi A,Tafazzoli-Shadpour M,Shokrgozar MA

更新日期：2018-01-01 00:00:00

abstract：:Anti-angiogenic vascular endothelial growth factor A (VEGF) 165b and pro-angiogenic VEGF 165 are generated from the same transcript, and their relative amounts are dependent on alternative splicing. The role of VEGF 165b has not been investigated in as much detail as VEGF 165, although it appears to be highly expresse...

journal_title：Cell adhesion & migration

authors： Peiris-Pagès M

更新日期：2012-11-01 00:00:00

abstract：:It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus wh...

journal_title：Cell adhesion & migration

authors： van den Berg MC,Burgering BM

更新日期：2014-01-01 00:00:00

abstract：:The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences i...

journal_title：Cell adhesion & migration

authors： Fagotto F,Winklbauer R,Rohani N

更新日期：2014-01-01 00:00:00

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in the cerebrospinal fluid. Nevertheless, its role in the central nervous system is far from clear. Here, we present evidence that L-PGDS induces glial cell migration and morphological changes in vitro and in vivo. We also identified...

journal_title：Cell adhesion & migration

authors： Suk K

更新日期：2012-05-01 00:00:00

abstract：:Galectin-1 (gal-1), a member of the mammalian β-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation. In previous studies, we demonstrated that gal-1 induces cell differentiation processes on the membrane of choriocarc...

journal_title：Cell adhesion & migration

authors： Hutter S,Morales-Prieto DM,Andergassen U,Tschakert L,Kuhn C,Hofmann S,Markert UR,Jeschke U

更新日期：2016-03-03 00:00:00

abstract：:The aim of this study was to compare uniaxial traction forces exerted by different cell types using a novel sensor design and to test the dependence of measured forces on cytoskeletal integrity. The sensor design detects forces generated between 2 contact points by cells spanning a gap. The magnitude of these forces v...

journal_title：Cell adhesion & migration

authors： Swierczewski R,Hedley J,Redfern CP

更新日期：2016-05-03 00:00:00

abstract：:Cellular motility is a fundamental process essential for embryonic development, wound healing, immune responses, and tissues development. Cells are mostly moving by crawling on external, or inside, substrates which can differ in their surface composition, geometry, and dimensionality. Cells can adopt different migrati...

journal_title：Cell adhesion & migration

authors： Siton-Mendelson O,Bernheim-Groswasser A

更新日期：2016-09-02 00:00:00

abstract：:All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging technologies have provided significant insights into the mechanism of...

journal_title：Cell adhesion & migration

authors： Mazzon C,Viola A

更新日期：2007-01-01 00:00:00

abstract：:Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds...

journal_title：Cell adhesion & migration

authors： Arriagada C,Silva P,Torres VA

更新日期：2019-12-01 00:00:00

abstract：:Acute mountain sickness (AMS) can cause capillary hyper-permeability and vasogenic edema. However, its underlying mechanisms remained unclear and there is no previous in vitro study on AMS. We therefore conducted an in vitro study and examined whether continuous hypobaric hypoxia (CHH) could alter expression of juncti...

journal_title：Cell adhesion & migration

authors： Souvannakitti D,Peerapen P,Thongboonkerd V

更新日期：2017-07-04 00:00:00