Abstract:
:The micro-environment of cancer cells in the body is mechanically stiffer than that of normal cells. We cultured three breast cell lines of MCF10A-normal, MCF7-noninvasive, and MDA-MB-231-invasive on PDMS substrates with different elastic moduli and different cellular features were examined.Effects of substrate stiffness on cell behavior were evident among all cell lines. Cancerous cells were more sensitive to substrate stiffness for cell behaviors related to cell motility and migration which are necessary for invasion. The invasive cancerous cells were the most motile on substrates with moderate stiffness followed by non-invasive cancerous cells. Gene markers alterations were generally according to the analyzed cell movement parameters. Results suggest that alterations in matrix stiffness may be related to cancer disease and progression.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Ansardamavandi A,Tafazzoli-Shadpour M,Shokrgozar MAdoi
10.1080/19336918.2018.1475803subject
Has Abstractpub_date
2018-01-01 00:00:00pages
472-488issue
5eissn
1933-6918issn
1933-6926journal_volume
12pub_type
杂志文章abstract::Acute mountain sickness (AMS) can cause capillary hyper-permeability and vasogenic edema. However, its underlying mechanisms remained unclear and there is no previous in vitro study on AMS. We therefore conducted an in vitro study and examined whether continuous hypobaric hypoxia (CHH) could alter expression of juncti...
journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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doi:10.4161/cam.4.2.11476
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abstract::Growth factors regulate a diverse array of cellular functions including proliferation, survival, movement, and the ability to do this often involves interactions with the extracellular matrix (ECM) and particularly heparan sulfate proteoglycans (HSPGs). HSPGs have been shown to sequester growth factors, and to act as ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.4.12427
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abstract::During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into the dorsal mantle layer after a 'waiting period' of a few days. We reve...
journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Cell adhesion & migration
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doi:10.4161/cam.21076
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.4.4.13594
更新日期:2010-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/19336918.2014.970028
更新日期:2014-01-01 00:00:00
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journal_title:Cell adhesion & migration
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doi:10.1080/19336918.2016.1221563
更新日期:2016-09-02 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.1.2.4547
更新日期:2007-04-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1107693
更新日期:2015-01-01 00:00:00
abstract::The class-specific transcription factors Knot and Cut act during dendrite arbor development to define the characteristic dendrite branching pattern of the Drosophila class IV dendritic arborisation sensory neurons. Knot mediates dendrite arbor outgrowth and branching via a microtubule-based program that includes upreg...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.2.6395
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1183867
更新日期:2017-01-02 00:00:00
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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更新日期:2016-03-03 00:00:00
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journal_title:Cell adhesion & migration
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更新日期:2017-03-04 00:00:00
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00