Anchoring stem cells in the niche by cell adhesion molecules.

abstract：:Tumor budding occurs at the invasive front of cancer; the tumor cells involved have metastatic and stemness features, indicating a poor prognosis. Tumor budding is partly responsible for cancer metastasis, and its initiation is based on the epithelial-mesenchymal transition (EMT) process. The EMT process involves the ...

journal_title：Cell adhesion & migration

authors： Li H,Xu F,Li S,Zhong A,Meng X,Lai M

更新日期：2016-07-03 00:00:00

abstract：:The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with...

journal_title：Cell adhesion & migration

authors： Candelier JJ

更新日期：2016-03-03 00:00:00

abstract：:It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...

journal_title：Cell adhesion & migration

authors： Krull CE

更新日期：2010-10-01 00:00:00

abstract：:In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions charact...

journal_title：Cell adhesion & migration

authors： Galkina SI,Fedorova NV,Stadnichuk VI,Sud'ina GF

更新日期：2013-03-01 00:00:00

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in the cerebrospinal fluid. Nevertheless, its role in the central nervous system is far from clear. Here, we present evidence that L-PGDS induces glial cell migration and morphological changes in vitro and in vivo. We also identified...

journal_title：Cell adhesion & migration

authors： Suk K

更新日期：2012-05-01 00:00:00

abstract：:Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion form...

journal_title：Cell adhesion & migration

authors： Han SJ,Rodriguez ML,Al-Rekabi Z,Sniadecki NJ

更新日期：2016-09-02 00:00:00

abstract：:It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus wh...

journal_title：Cell adhesion & migration

authors： van den Berg MC,Burgering BM

更新日期：2014-01-01 00:00:00

abstract：:In the cortex of a motile cell, membrane-anchored actin filaments assemble into structures of varying shape and function. Filopodia are distinguished by a core of bundled actin filaments within finger-like extensions of the membrane. In a recent paper by Medalia et al(1) cryo-electron tomography has been used to recon...

journal_title：Cell adhesion & migration

authors： Gerisch G,Weber I

更新日期：2007-07-01 00:00:00

abstract：:Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-th...

journal_title：Cell adhesion & migration

authors： Dumbauld DW,García AJ

更新日期：2014-01-01 00:00:00

abstract：:Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are assoc...

journal_title：Cell adhesion & migration

authors： van den Dries K,Bolomini-Vittori M,Cambi A

更新日期：2014-01-01 00:00:00

abstract：:Genetically engineered, conditionally replicating herpes simplex viruses type 1 (HSV-1) are promising therapeutic agents for brain tumors and other solid cancers. They can replicate in situ, spread and exhibit oncolytic activity via a direct cytocidal effect. One of the advantages of HSV-1 is the capacity to incorpora...

journal_title：Cell adhesion & migration

authors： Todo T

更新日期：2008-07-01 00:00:00

abstract：:Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis. Bone remodeling consists of two phases: the removal of mineralized bone by osteoclasts and the formation of ne...

journal_title：Cell adhesion & migration

authors： Xu R

更新日期：2014-01-01 00:00:00

abstract：:The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as prolife...

journal_title：Cell adhesion & migration

authors： Horimoto Y,Polanska UM,Takahashi Y,Orimo A

更新日期：2012-05-01 00:00:00

abstract：:Anti-angiogenic vascular endothelial growth factor A (VEGF) 165b and pro-angiogenic VEGF 165 are generated from the same transcript, and their relative amounts are dependent on alternative splicing. The role of VEGF 165b has not been investigated in as much detail as VEGF 165, although it appears to be highly expresse...

journal_title：Cell adhesion & migration

authors： Peiris-Pagès M

更新日期：2012-11-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the third most frequent malignancy within urological oncology. However, the mechanisms responsible for RCC metastasis are still needed further illustration. Our present study revealed that a seven-transmembrane receptor G-protein coupled estrogen receptor (GPER) was highly detected in var...

journal_title：Cell adhesion & migration

authors： Guan BZ,Yan RL,Huang JW,Li FL,Zhong YX,Chen Y,Liu FN,Hu B,Huang SB,Yin LH

更新日期：2018-03-04 00:00:00

abstract：:Extensive research efforts have been conducted over the past decades to understand the processing of the Amyloid Precursor Protein (APP). APP cleavage leads to the production of the beta-amyloid peptide (Abeta), which is the major constituent of the amyloid core of senile plaques found in the brains of patients with A...

journal_title：Cell adhesion & migration

authors： Khalifa NB,Van Hees J,Tasiaux B,Huysseune S,Smith SO,Constantinescu SN,Octave JN,Kienlen-Campard P

更新日期：2010-04-01 00:00:00

abstract：:Changes in cell shape are associated with a variety of processes including cell migration, axon outgrowth, cell division and vesicle trafficking. C. elegans UNC-53 and its vertebrate homologs, the Navigators, are required for the migration of cells and the outgrowth of neuronal processes. The identification of novel m...

journal_title：Cell adhesion & migration

authors： Stringham EG,Schmidt KL

更新日期：2009-10-01 00:00:00

abstract：:The term polarity refers to the differential distribution of the macromolecular elements of a cell, resulting in its asymmetry in function, shape and/or content. Polarity is a fundamental property of all metazoan cells in at least some stages, and is pivotal to processes such as epithelial differentiation (apical/basa...

journal_title：Cell adhesion & migration

authors： Gómez-Moutón C,Mañes S

更新日期：2007-04-01 00:00:00

abstract：:There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources s...

journal_title：Cell adhesion & migration

authors： Hou ZL,Liu Y,Mao XH,Wei CY,Meng MY,Liu YH,Zhuyun Yang Z,Zhu H,Short M,Bernard C,Xiao ZC

更新日期：2013-09-01 00:00:00

abstract：:Integrins regulate cell attachment and migration through interactions with specific proteins in the extra-cellular matrix. Heterotrimeric G proteins are essential signal transduction proteins that intersect with integrin signaling to regulate fundamental cellular behaviors. Although integrin and G protein signaling of...

journal_title：Cell adhesion & migration

authors： Kong T,Xu D,Tran M,Denker BM

更新日期：2010-07-01 00:00:00

abstract：:Growth factors regulate a diverse array of cellular functions including proliferation, survival, movement, and the ability to do this often involves interactions with the extracellular matrix (ECM) and particularly heparan sulfate proteoglycans (HSPGs). HSPGs have been shown to sequester growth factors, and to act as ...

journal_title：Cell adhesion & migration

authors： Symes K,Smith EM,Mitsi M,Nugent MA

更新日期：2010-10-01 00:00:00

abstract：:During brain development, billions of neurons organize into highly specific circuits. To form specific circuits, neurons must build the appropriate types of synapses with appropriate types of synaptic partners while avoiding incorrect partners in a dense cellular environment. Defining the cellular and molecular rules ...

journal_title：Cell adhesion & migration

authors： Basu R,Taylor MR,Williams ME

更新日期：2015-01-01 00:00:00

abstract：:Directional cell migration is essential for almost all organisms during embryonic development, in adult life and contributes to pathological conditions. This is particularly critical during embryogenesis where it is essential that cells end up in their correct, precise locations in order to build a normal embryo. Many...

journal_title：Cell adhesion & migration

authors： Carmona-Fontaine C,Matthews H,Mayor R

更新日期：2008-10-01 00:00:00

abstract：:Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adhesions in the cell....

journal_title：Cell adhesion & migration

authors： Bach CT,Schevzov G,Bryce NS,Gunning PW,O'Neill GM

更新日期：2010-04-01 00:00:00

abstract：:Familial dysautonomia (FD) is a hereditary neuronal disease characterized by poor development and progressive degeneration of the sensory and autonomic nervous system. Majority of FD (99.5%) results from a single nucleotide point mutation in the IKBKAP gene encoding IKAP, also known as elongation protein 1 (ELP1). The...

journal_title：Cell adhesion & migration

authors： Naumanen T,Johansen LD,Coffey ET,Kallunki T

更新日期：2008-10-01 00:00:00

abstract：:Coordinated changes of actin cytoskeleton and cell adhesion accompany maturation of lymphoid cells, their migration through lymphoid organs and to sites of inflammation, as well as metastasis of transformed cells. Here we discuss the central role of the actin-regulating adaptor protein, paxillin, during lymphocyte tra...

journal_title：Cell adhesion & migration

authors： Romanova LY,Mushinski JF

更新日期：2011-11-01 00:00:00

abstract：:For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...

journal_title：Cell adhesion & migration

authors： Khanna A,Indracanti N,Chakrabarti R,Indraganti PK

更新日期：2020-12-01 00:00:00

abstract：:The ability of blood vessels to sense and respond to stimuli such as fluid flow, shear stress, and trafficking of immune cells is critical to the proper function of the vascular system. Endothelial cells constantly remodel their cell-cell junctions and the underlying cytoskeletal network in response to these exogenous...

journal_title：Cell adhesion & migration

authors： Wilson CW,Ye W

更新日期：2014-01-01 00:00:00

abstract：:Directional cell migration requires cell polarization and asymmetric distribution of cell signaling. Focal adhesions and microtubules are two systems which are essential for these. It was shown that these two systems closely interact with each other. It is known that microtubule targeting stimulates focal adhesion dis...

journal_title：Cell adhesion & migration

authors： Efimov A,Kaverina I

更新日期：2009-07-01 00:00:00

abstract：:During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into the dorsal mantle layer after a 'waiting period' of a few days. We reve...

journal_title：Cell adhesion & migration

authors： Masuda T,Yaginuma H,Sakuma C,Ono K

更新日期：2009-04-01 00:00:00