Semaphorin 3A: A new player in bone remodeling.

abstract：:ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa GTPase with homology to Ras. Re-expression of ARHI inhibits ovarian cancer growth, initiates autophagy and induces tumor dormancy. Recent studies have...

journal_title：Cell adhesion & migration

authors： Lu Z,Bast RC Jr

更新日期：2013-03-01 00:00:00

abstract：:The mechanical and structural properties of the extracellular matrix (ECM) play an important role in regulating cell fate. The natural ECM has a complex fibrillar structure and shows nonlinear mechanical properties, which are both difficult to mimic synthetically. Therefore, systematically testing the influence of ECM...

journal_title：Cell adhesion & migration

authors： Bruekers SM,Jaspers M,Hendriks JM,Kurniawan NA,Koenderink GH,Kouwer PH,Rowan AE,T S Huck W

更新日期：2016-09-02 00:00:00

abstract：:The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p5...

journal_title：Cell adhesion & migration

authors： Mak AS

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tum...

journal_title：Cell adhesion & migration

authors： Hohmann T,Grabiec U,Ghadban C,Feese K,Dehghani F

更新日期：2017-01-02 00:00:00

abstract：:Eph receptors and their membrane-bound ligands are intimately involved in the control of morphogenic processes during embryonic development and adult tissue homeostasis. By their ability to orchestrate cell migration, pattern formation and tissue integrity they are also prone to be involved in carcinogenic growth. In ...

journal_title：Cell adhesion & migration

authors： Kaenel P,Mosimann M,Andres AC

更新日期：2012-03-01 00:00:00

abstract：:Familial dysautonomia (FD) is a hereditary neuronal disease characterized by poor development and progressive degeneration of the sensory and autonomic nervous system. Majority of FD (99.5%) results from a single nucleotide point mutation in the IKBKAP gene encoding IKAP, also known as elongation protein 1 (ELP1). The...

journal_title：Cell adhesion & migration

authors： Naumanen T,Johansen LD,Coffey ET,Kallunki T

更新日期：2008-10-01 00:00:00

abstract：:Eph signaling, which arises following stimulation by ephrins, is known to induce opposite cell behaviors such as promoting and inhibiting cell adhesion as well as promoting cell-cell adhesion and repulsion by altering the organization of the actin cytoskeleton and influencing the adhesion activities of integrins. Howe...

journal_title：Cell adhesion & migration

authors： Saeki N,Nishino S,Shimizu T,Ogawa K

更新日期：2015-01-01 00:00:00

abstract：:Monocyte-extracellular matrix interactions have been implicated in atherosclerosis pathophysiology. Laminin, the main basement membrane protein contains cell binding domains that can be cryptic, presented only after protein modification. In the present study we evaluated monocyte attachment to laminin-1 in the presenc...

journal_title：Cell adhesion & migration

authors： Kostidou E,Trachana V,Topouridou K,Paletas K,Tsapas A,Kaloyianni M,Koliakos G

更新日期：2009-04-01 00:00:00

abstract：:Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5...

journal_title：Cell adhesion & migration

authors： Spenlé C,Simon-Assmann P,Orend G,Miner JH

更新日期：2013-01-01 00:00:00

abstract：:The proper establishment and organogenesis of the placenta is crucial for intrauterine fetal growth and development. Endometrial invasion by the extravillous trophoblast cells, as well as formation of the syncytiotrophoblast (STB), are of vital importance for placental function. Trophoblast migration and invasion is o...

journal_title：Cell adhesion & migration

authors： Kohan-Ghadr HR,Kadam L,Jain C,Armant DR,Drewlo S

更新日期：2016-03-03 00:00:00

abstract：:Over 20 years ago, protrusive, F-actin-based membrane structures, termed invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia penetrate artificial or explanted extracellular matrices in 2D culture conditions and have been hypothesized to facilitate the migration of cancer cells through base...

journal_title：Cell adhesion & migration

authors： Lohmer LL,Kelley LC,Hagedorn EJ,Sherwood DR

更新日期：2014-01-01 00:00:00

abstract：:Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...

journal_title：Cell adhesion & migration

authors： La Gatta A,D'Agostino A,Schiraldi C,Colella G,Cirillo N

更新日期：2019-12-01 00:00:00

abstract：:It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...

journal_title：Cell adhesion & migration

authors： Krull CE

更新日期：2010-10-01 00:00:00

abstract：:A deterministic model of dermal wound invasion, which accounts for the platelet-derived growth factor (PDGF) gradient sensing mechanism in fibroblasts mediated by cell surface receptors and the phosphoinositide 3-kinase (PI3K) signal transduction pathway, was previously described (Biophys J 2006; 90:2297-308). Here, w...

journal_title：Cell adhesion & migration

authors： Monine MI,Haugh JM

更新日期：2008-04-01 00:00:00

abstract：:Anti-angiogenic vascular endothelial growth factor A (VEGF) 165b and pro-angiogenic VEGF 165 are generated from the same transcript, and their relative amounts are dependent on alternative splicing. The role of VEGF 165b has not been investigated in as much detail as VEGF 165, although it appears to be highly expresse...

journal_title：Cell adhesion & migration

authors： Peiris-Pagès M

更新日期：2012-11-01 00:00:00

abstract：:The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as prolife...

journal_title：Cell adhesion & migration

authors： Horimoto Y,Polanska UM,Takahashi Y,Orimo A

更新日期：2012-05-01 00:00:00

abstract：:Optimising response to tyrosine kinase inhibitors in cancer remains an extensive field of research. Intravital imaging is an emerging tool, which can be used in drug discovery to facilitate and fine-tune maximum drug response in live tumors. A greater understanding of intratumoural delivery and pharmacodynamics of a d...

journal_title：Cell adhesion & migration

authors： Nobis M,McGhee EJ,Herrmann D,Magenau A,Morton JP,Anderson KI,Timpson P

更新日期：2014-01-01 00:00:00

abstract：:The ability of blood vessels to sense and respond to stimuli such as fluid flow, shear stress, and trafficking of immune cells is critical to the proper function of the vascular system. Endothelial cells constantly remodel their cell-cell junctions and the underlying cytoskeletal network in response to these exogenous...

journal_title：Cell adhesion & migration

authors： Wilson CW,Ye W

更新日期：2014-01-01 00:00:00

abstract：:When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn dete...

journal_title：Cell adhesion & migration

authors： James J,Tun W,Clark A

更新日期：2016-03-03 00:00:00

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in the cerebrospinal fluid. Nevertheless, its role in the central nervous system is far from clear. Here, we present evidence that L-PGDS induces glial cell migration and morphological changes in vitro and in vivo. We also identified...

journal_title：Cell adhesion & migration

authors： Suk K

更新日期：2012-05-01 00:00:00

abstract：:Cell surface receptors of the integrin family are pivotal to cell adhesion and migration. The activation state of heterodimeric alphabeta integrins is correlated to the association state of the single-pass alpha and beta transmembrane domains. The association of integrin alphaIIbbeta3 transmembrane domains, resulting ...

journal_title：Cell adhesion & migration

authors： Ulmer TS

更新日期：2010-04-01 00:00:00

abstract：:The critical role of migration and invasion in cancer metastasis warrants new therapeutic approaches targeting the machinery regulating cell migration and invasion. While 2-dimensional (2D) models have helped identify a range of adhesion molecules, cytoskeletal components and regulators that are potentially important ...

journal_title：Cell adhesion & migration

authors： Bradbury P,Fabry B,O'Neill GM

更新日期：2012-09-01 00:00:00

abstract：:The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces ...

journal_title：Cell adhesion & migration

authors： Anderson NR,Buffone A Jr,Hammer DA

更新日期：2019-12-01 00:00:00

abstract：:Activation of platelet derived growth factor (PDGF) receptors causes context-dependent cellular responses, including proliferation and migration, and studies in model organisms have demonstrated that this receptor family (PDGFRα and PDGFRβ) is required in many mesenchymal and migratory cell populations during embryoni...

journal_title：Cell adhesion & migration

authors： Smith CL,Tallquist MD

更新日期：2010-10-01 00:00:00

abstract：:PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpr...

journal_title：Cell adhesion & migration

authors： Pang Y,Zhang Z,Wang Z,Wang Y,Yan Y,Li S,Tong H

更新日期：2019-12-01 00:00:00

abstract：:The hypotheses emerging from basic research on colorectal liver metastases must be tested in clinical situations for the adaptation of current treatment strategies. Pre-metastatic niches have been shown to exist in human colorectal synchronous metastases, with the liver parenchyma adjacent to the synchronous liver met...

journal_title：Cell adhesion & migration

authors： Eveno C,Pocard M

更新日期：2012-11-01 00:00:00

abstract：:The actin cytoskeleton plays a key role in regulating cell motility. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells that is conserved among a variety of vertebrates. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (...

journal_title：Cell adhesion & migration

authors： Mayanagi T,Sobue K

更新日期：2011-03-01 00:00:00

abstract：:Adhesion of epithelial cell to each other and to extracellular matrix, as well as cell migration ability and cytoskeleton organization undergo significant alterations in the course of neoplastic transformation, but regulatory mechanisms involved in these processes are not fully understood. Here, we studied the role of...

journal_title：Cell adhesion & migration

authors： Regev M,Sabanay H,Kartvelishvily E,Kam Z,Bershadsky AD

更新日期：2017-07-04 00:00:00

abstract：:Normal vascular development and angiogenesis is regulated by coordinated changes in cell-cell and cell-extracellular matrix (ECM) interactions. The Homeobox (Hox) family of transcription factors coordinately regulate expression of matrix degrading proteinases, integrins and ECM components and profoundly impact vascula...

journal_title：Cell adhesion & migration

authors： Arderiu G,Cuevas I,Chen A,Carrio M,East L,Boudreau NJ

更新日期：2007-10-01 00:00:00

abstract：:During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into the dorsal mantle layer after a 'waiting period' of a few days. We reve...

journal_title：Cell adhesion & migration

authors： Masuda T,Yaginuma H,Sakuma C,Ono K

更新日期：2009-04-01 00:00:00