Abstract:
:The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces displaying either ICAM-1 or ICAM-1 and VCAM-1, but migrate downstream on surfaces displaying only VCAM-1. Cells completing the cascade on HUVECs initially migrate upstream before reverting to more random migration, partly caused by transmigration of cells migrating against the flow. Furthermore, cells migrating upstream transmigrate faster than cells migrating downstream. On HUVECs, blocking interactions between LFA-1 and ICAM-1 resulted in downstream migration and slower transmigration. These results further suggest a possible physiological role for upstream migration in vivo.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Anderson NR,Buffone A Jr,Hammer DAdoi
10.1080/19336918.2019.1587269subject
Has Abstractpub_date
2019-12-01 00:00:00pages
163-168issue
1eissn
1933-6918issn
1933-6926journal_volume
13pub_type
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