Abstract:
:Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell adhesion by linking transmembrane proteins to the actin cytoskeleton. Additionally, they participate in recruitment of signaling receptors and cytoplasmic proteins to the membrane. During cellular invasion or migration, AJs are dynamically regulated and their composition modified to initiate changes in signaling pathways and cytoskeleton organization involved in cellular motility. Loss of E-cadherin, a key component of AJs, is characteristic of epithelial-mesenchymal-transition (EMT) and is associated with tumor cell invasion. We will review recent findings describing novel mechanisms involved in E-cadherin transcription regulation, endocytosis of E-cadherin and signaling associated with loss of AJs as well as reorganization of the AJ during EMT.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Le Bras GF,Taubenslag KJ,Andl CDdoi
10.4161/cam.21326subject
Has Abstractpub_date
2012-07-01 00:00:00pages
365-73issue
4eissn
1933-6918issn
1933-6926pii
21326journal_volume
6pub_type
杂志文章,评审abstract::Neurodegenerative diseases have become a global issue due to the aging population. These disorders affect a vast patient population and represent a huge area of unmet therapeutic need. Axon degeneration is a common pathological character of those neurodegenerative diseases. It results in the loss of communication betw...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.1.7483
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abstract::Anti-angiogenic vascular endothelial growth factor A (VEGF) 165b and pro-angiogenic VEGF 165 are generated from the same transcript, and their relative amounts are dependent on alternative splicing. The role of VEGF 165b has not been investigated in as much detail as VEGF 165, although it appears to be highly expresse...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.22439
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abstract::Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1120397
更新日期:2016-03-03 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2019.1644856
更新日期:2019-12-01 00:00:00
abstract::The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2017.1405208
更新日期:2018-01-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2018.1460012
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abstract::The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences i...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1120398
更新日期:2016-05-03 00:00:00
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journal_title:Cell adhesion & migration
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1247145
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abstract::Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell. Recent findings implicate cyc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.3.11131
更新日期:2010-07-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.1.4.5448
更新日期:2007-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.2.6511
更新日期:2008-04-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.2.10592
更新日期:2010-04-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.4.9451
更新日期:2009-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.2.11476
更新日期:2010-04-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.2.14398
更新日期:2011-03-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.2.8207
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journal_title:Cell adhesion & migration
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更新日期:2012-11-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1129481
更新日期:2016-07-03 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21076
更新日期:2012-05-01 00:00:00
abstract::Familial dysautonomia (FD) is a hereditary neuronal disease characterized by poor development and progressive degeneration of the sensory and autonomic nervous system. Majority of FD (99.5%) results from a single nucleotide point mutation in the IKBKAP gene encoding IKAP, also known as elongation protein 1 (ELP1). The...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.4.6630
更新日期:2008-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.4.8604
更新日期:2009-10-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2014.1000072
更新日期:2015-01-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21559
更新日期:2012-09-01 00:00:00
abstract::Physical cues from the extracellular environment that influence cell shape and directional migration are transduced into changes in cytoskeletal organization and biochemistry through integrin-based cell adhesions to extracellular matrix (ECM). Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin a...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.21672
更新日期:2012-11-01 00:00:00