Abstract:
:ARHI is an imprinted tumor suppressor gene that is downregulated in > 60% of ovarian cancers, associated with decreased progression-free survival. ARHI encodes a 26 kDa GTPase with homology to Ras. Re-expression of ARHI inhibits ovarian cancer growth, initiates autophagy and induces tumor dormancy. Recent studies have demonstrated that ARHI also plays a particularly important role in ovarian cancer cell migration. Re-expression of ARHI decreases motility of IL-6- and EGF-stimulated SKOv3 and Hey ovarian cancer cells, inhibiting both chemotaxis and haptotaxis. ARHI inhibits cell migration by binding and sequestering STAT3 in the cytoplasm, and preventing STAT3 translocation to the nucleus and localization in focal adhesion complexes. Re-expression of ARHI inhibits FAK (Y397) phosphorylation, disrupts focal adhesions and blocks FAK-mediated RhoA signaling, resulting in decreased levels of GTP-RhoA. Re-expression of ARHI disrupts formation of actin stress fibers in a FAK- and RhoA-dependent manner. Recent studies indicate that re-expression of ARHI inhibits expression of β-1 integrin which may also contribute to inhibition of migration, adhesion and invasion.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Lu Z,Bast RC Jrdoi
10.4161/cam.23648subject
Has Abstractpub_date
2013-03-01 00:00:00pages
232-6issue
2eissn
1933-6918issn
1933-6926pii
23648journal_volume
7pub_type
评论,杂志文章abstract::Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell adhesion by linking transmembrane proteins to the actin cytoskeleton. Additionally, they participate in recruitment of signaling recept...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21326
更新日期:2012-07-01 00:00:00
abstract::Directional cell migration requires cell polarization and asymmetric distribution of cell signaling. Focal adhesions and microtubules are two systems which are essential for these. It was shown that these two systems closely interact with each other. It is known that microtubule targeting stimulates focal adhesion dis...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.3.8858
更新日期:2009-07-01 00:00:00
abstract::For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mo...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2020.1842131
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to compare uniaxial traction forces exerted by different cell types using a novel sensor design and to test the dependence of measured forces on cytoskeletal integrity. The sensor design detects forces generated between 2 contact points by cells spanning a gap. The magnitude of these forces v...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1120398
更新日期:2016-05-03 00:00:00
abstract::Cellular studies have long been performed on the bench top, within Petri dishes and flasks that expose cells to surroundings that differ greatly from their native environment. The complexity of a human tissue is such that to truly replicate a cell's physiologic microenvironment in vitro is currently impossible. It is ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.21076
更新日期:2012-05-01 00:00:00
abstract::When trophoblasts migrate and invade in vivo, they do so by interacting with a range of other cell types, extracellular matrix proteins, chemotactic factors and physical forces such as fluid shear stress. These factors combine to influence overall trophoblast migration and invasion into the decidua, which in turn dete...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1083667
更新日期:2016-03-03 00:00:00
abstract::An expanding body of evidence demonstrates that cells undergoing apoptosis send out a selection of molecular navigational signals including proteins, lipids and nucleotides that serve to recruit phagocytes to the dying targets which are subsequently engulfed and removed. This homeostatic process is essentially non-phl...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.5.4.16743
更新日期:2011-07-01 00:00:00
abstract::The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p5...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.2.14375
更新日期:2011-03-01 00:00:00
abstract::Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2018.1494997
更新日期:2019-12-01 00:00:00
abstract::Over 20 years ago, protrusive, F-actin-based membrane structures, termed invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia penetrate artificial or explanted extracellular matrices in 2D culture conditions and have been hypothesized to facilitate the migration of cancer cells through base...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.28406
更新日期:2014-01-01 00:00:00
abstract::The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as prolife...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.20631
更新日期:2012-05-01 00:00:00
abstract::Angiogenesis, the growth of new blood vessels from pre-existing vessels, is a process involving endothelial cell proliferation, migration and vascular tube formation. One of the key molecules that regulate this process is the integrin beta3 subunit, a cell adhesion receptor that forms a heterodimer with the integrin a...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.1.7252
更新日期:2009-01-01 00:00:00
abstract::Directional cell migration is essential for almost all organisms during embryonic development, in adult life and contributes to pathological conditions. This is particularly critical during embryogenesis where it is essential that cells end up in their correct, precise locations in order to build a normal embryo. Many...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.4.6747
更新日期:2008-10-01 00:00:00
abstract::Galectin-1 (gal-1), a member of the mammalian β-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation. In previous studies, we demonstrated that gal-1 induces cell differentiation processes on the membrane of choriocarc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2015.1089377
更新日期:2016-03-03 00:00:00
abstract::The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extr...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2017.1405208
更新日期:2018-01-01 00:00:00
abstract::Physical cues from the extracellular environment that influence cell shape and directional migration are transduced into changes in cytoskeletal organization and biochemistry through integrin-based cell adhesions to extracellular matrix (ECM). Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin a...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.21672
更新日期:2012-11-01 00:00:00
abstract::A deterministic model of dermal wound invasion, which accounts for the platelet-derived growth factor (PDGF) gradient sensing mechanism in fibroblasts mediated by cell surface receptors and the phosphoinositide 3-kinase (PI3K) signal transduction pathway, was previously described (Biophys J 2006; 90:2297-308). Here, w...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.2.2.6511
更新日期:2008-04-01 00:00:00
abstract::Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell. Recent findings implicate cyc...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.3.11131
更新日期:2010-07-01 00:00:00
abstract::Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-th...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.29139
更新日期:2014-01-01 00:00:00
abstract::The goal of this review is to highlight how emerging new models of filopodia assembly, which include tissue specific actin-bundling proteins, could provide more comprehensive representations of filopodia assembly that would describe more adequately and effectively the complexity and plasticity of epithelial cells. Th...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.5.5.17644
更新日期:2011-09-01 00:00:00
abstract::Spinal cord injury (SCI) has been regarded clinically as an irreversible damage caused by tissue contusion due to a blunt external force. Past research had focused on the analysis of the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as tissue damage and neural cell d...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.3.1.7372
更新日期:2009-01-01 00:00:00
abstract::In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions charact...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.23130
更新日期:2013-03-01 00:00:00
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journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.22439
更新日期:2012-11-01 00:00:00
abstract::Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion form...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1221563
更新日期:2016-09-02 00:00:00
abstract::Acute mountain sickness (AMS) can cause capillary hyper-permeability and vasogenic edema. However, its underlying mechanisms remained unclear and there is no previous in vitro study on AMS. We therefore conducted an in vitro study and examined whether continuous hypobaric hypoxia (CHH) could alter expression of juncti...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.1080/19336918.2016.1225633
更新日期:2017-07-04 00:00:00
abstract::Normal vascular development and angiogenesis is regulated by coordinated changes in cell-cell and cell-extracellular matrix (ECM) interactions. The Homeobox (Hox) family of transcription factors coordinately regulate expression of matrix degrading proteinases, integrins and ECM components and profoundly impact vascula...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.1.4.5448
更新日期:2007-10-01 00:00:00
abstract::Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in the cerebrospinal fluid. Nevertheless, its role in the central nervous system is far from clear. Here, we present evidence that L-PGDS induces glial cell migration and morphological changes in vitro and in vivo. We also identified...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.20251
更新日期:2012-05-01 00:00:00
abstract::Extensive research efforts have been conducted over the past decades to understand the processing of the Amyloid Precursor Protein (APP). APP cleavage leads to the production of the beta-amyloid peptide (Abeta), which is the major constituent of the amyloid core of senile plaques found in the brains of patients with A...
journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.4.2.11476
更新日期:2010-04-01 00:00:00
abstract::Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2015.1120397
更新日期:2016-03-03 00:00:00
abstract::Cancer exosomes are gaining considerable amount of attention in basic and applied clinical research for their established role in the modulation of the tumor niche, and their broad-range contribution to tumor-host cross-talk. Supporting evidence to their role in tumorigenesis comes from the observation that exosome se...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.1080/19336918.2016.1225632
更新日期:2017-03-04 00:00:00