Foxc2 transcription factor as a regulator of angiogenesis via induction of integrin beta3 expression.

abstract：:Optimising response to tyrosine kinase inhibitors in cancer remains an extensive field of research. Intravital imaging is an emerging tool, which can be used in drug discovery to facilitate and fine-tune maximum drug response in live tumors. A greater understanding of intratumoural delivery and pharmacodynamics of a d...

journal_title：Cell adhesion & migration

authors： Nobis M,McGhee EJ,Herrmann D,Magenau A,Morton JP,Anderson KI,Timpson P

更新日期：2014-01-01 00:00:00

abstract：:Eph signaling, which arises following stimulation by ephrins, is known to induce opposite cell behaviors such as promoting and inhibiting cell adhesion as well as promoting cell-cell adhesion and repulsion by altering the organization of the actin cytoskeleton and influencing the adhesion activities of integrins. Howe...

journal_title：Cell adhesion & migration

authors： Saeki N,Nishino S,Shimizu T,Ogawa K

更新日期：2015-01-01 00:00:00

abstract：:Visceral adipose tissue (VAT) may play a critical role in atherosclerotic cardiovascular disease. The goal of this study was to determine the effect of human VAT-released pro‑inflammatory cytokines on monocyte adhesion to the endothelium. The cytokine effects on monocyte adhesion to the endothelial cells (ECs) were te...

journal_title：Cell adhesion & migration

authors： Cejkova S,Kubatova H,Thieme F,Janousek L,Fronek J,Poledne R,Kralova Lesna I

更新日期：2019-12-01 00:00:00

abstract：:Hyaluronic acid (HA) preparations are widely used in clinical practice and recent data suggest that commercially available HA-based compounds promote ulcer re-epithelialization and induce pain relief. However, the pathophysiological basis of these effects remains poorly understood. In the present study, we investigate...

journal_title：Cell adhesion & migration

authors： La Gatta A,D'Agostino A,Schiraldi C,Colella G,Cirillo N

更新日期：2019-12-01 00:00:00

abstract：:Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis. Bone remodeling consists of two phases: the removal of mineralized bone by osteoclasts and the formation of ne...

journal_title：Cell adhesion & migration

authors： Xu R

更新日期：2014-01-01 00:00:00

abstract：:Familial dysautonomia (FD) is a hereditary neuronal disease characterized by poor development and progressive degeneration of the sensory and autonomic nervous system. Majority of FD (99.5%) results from a single nucleotide point mutation in the IKBKAP gene encoding IKAP, also known as elongation protein 1 (ELP1). The...

journal_title：Cell adhesion & migration

authors： Naumanen T,Johansen LD,Coffey ET,Kallunki T

更新日期：2008-10-01 00:00:00

abstract：:It has long been thought that the same molecules guide both trunk neural crest cells and motor axons as these cell types grow and extend to their target regions in developing embryos. There are common territories that are navigated by these cell types: both cells grow through the rostral portion of the somitic sclerot...

journal_title：Cell adhesion & migration

authors： Krull CE

更新日期：2010-10-01 00:00:00

abstract：:Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adhesions in the cell....

journal_title：Cell adhesion & migration

authors： Bach CT,Schevzov G,Bryce NS,Gunning PW,O'Neill GM

更新日期：2010-04-01 00:00:00

abstract：:There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources s...

journal_title：Cell adhesion & migration

authors： Hou ZL,Liu Y,Mao XH,Wei CY,Meng MY,Liu YH,Zhuyun Yang Z,Zhu H,Short M,Bernard C,Xiao ZC

更新日期：2013-09-01 00:00:00

abstract：:Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell. Recent findings implicate cyc...

journal_title：Cell adhesion & migration

authors： Tripathi BK,Zelenka PS

更新日期：2010-07-01 00:00:00

abstract：:A deterministic model of dermal wound invasion, which accounts for the platelet-derived growth factor (PDGF) gradient sensing mechanism in fibroblasts mediated by cell surface receptors and the phosphoinositide 3-kinase (PI3K) signal transduction pathway, was previously described (Biophys J 2006; 90:2297-308). Here, w...

journal_title：Cell adhesion & migration

authors： Monine MI,Haugh JM

更新日期：2008-04-01 00:00:00

abstract：:Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds...

journal_title：Cell adhesion & migration

authors： Arriagada C,Silva P,Torres VA

更新日期：2019-12-01 00:00:00

abstract：:Changes in cell shape are associated with a variety of processes including cell migration, axon outgrowth, cell division and vesicle trafficking. C. elegans UNC-53 and its vertebrate homologs, the Navigators, are required for the migration of cells and the outgrowth of neuronal processes. The identification of novel m...

journal_title：Cell adhesion & migration

authors： Stringham EG,Schmidt KL

更新日期：2009-10-01 00:00:00

abstract：:The goal of this review is to highlight how emerging new models of filopodia assembly, which include tissue specific actin-bundling proteins, could provide more comprehensive representations of filopodia assembly that would describe more adequately and effectively the complexity and plasticity of epithelial cells.  Th...

journal_title：Cell adhesion & migration

authors： Khurana S,George SP

更新日期：2011-09-01 00:00:00

abstract：:Physical cues from the extracellular environment that influence cell shape and directional migration are transduced into changes in cytoskeletal organization and biochemistry through integrin-based cell adhesions to extracellular matrix (ECM). Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin a...

journal_title：Cell adhesion & migration

authors： Sero JE,German AE,Mammoto A,Ingber DE

更新日期：2012-11-01 00:00:00

abstract：:Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5...

journal_title：Cell adhesion & migration

authors： Spenlé C,Simon-Assmann P,Orend G,Miner JH

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to compare uniaxial traction forces exerted by different cell types using a novel sensor design and to test the dependence of measured forces on cytoskeletal integrity. The sensor design detects forces generated between 2 contact points by cells spanning a gap. The magnitude of these forces v...

journal_title：Cell adhesion & migration

authors： Swierczewski R,Hedley J,Redfern CP

更新日期：2016-05-03 00:00:00

abstract：:Cell surface receptors of the integrin family are pivotal to cell adhesion and migration. The activation state of heterodimeric alphabeta integrins is correlated to the association state of the single-pass alpha and beta transmembrane domains. The association of integrin alphaIIbbeta3 transmembrane domains, resulting ...

journal_title：Cell adhesion & migration

authors： Ulmer TS

更新日期：2010-04-01 00:00:00

abstract：:Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion form...

journal_title：Cell adhesion & migration

authors： Han SJ,Rodriguez ML,Al-Rekabi Z,Sniadecki NJ

更新日期：2016-09-02 00:00:00

abstract：:Spinal cord injury (SCI) has been regarded clinically as an irreversible damage caused by tissue contusion due to a blunt external force. Past research had focused on the analysis of the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as tissue damage and neural cell d...

journal_title：Cell adhesion & migration

authors： Shibuya S,Yamamoto T,Itano T

更新日期：2009-01-01 00:00:00

abstract：:Anti-angiogenic vascular endothelial growth factor A (VEGF) 165b and pro-angiogenic VEGF 165 are generated from the same transcript, and their relative amounts are dependent on alternative splicing. The role of VEGF 165b has not been investigated in as much detail as VEGF 165, although it appears to be highly expresse...

journal_title：Cell adhesion & migration

authors： Peiris-Pagès M

更新日期：2012-11-01 00:00:00

abstract：:Coordinated changes of actin cytoskeleton and cell adhesion accompany maturation of lymphoid cells, their migration through lymphoid organs and to sites of inflammation, as well as metastasis of transformed cells. Here we discuss the central role of the actin-regulating adaptor protein, paxillin, during lymphocyte tra...

journal_title：Cell adhesion & migration

authors： Romanova LY,Mushinski JF

更新日期：2011-11-01 00:00:00

abstract：:Directional cell migration is essential for almost all organisms during embryonic development, in adult life and contributes to pathological conditions. This is particularly critical during embryogenesis where it is essential that cells end up in their correct, precise locations in order to build a normal embryo. Many...

journal_title：Cell adhesion & migration

authors： Carmona-Fontaine C,Matthews H,Mayor R

更新日期：2008-10-01 00:00:00

abstract：:The micro-environment of cancer cells in the body is mechanically stiffer than that of normal cells. We cultured three breast cell lines of MCF10A-normal, MCF7-noninvasive, and MDA-MB-231-invasive on PDMS substrates with different elastic moduli and different cellular features were examined.Effects of substrate stiffn...

journal_title：Cell adhesion & migration

authors： Ansardamavandi A,Tafazzoli-Shadpour M,Shokrgozar MA

更新日期：2018-01-01 00:00:00

abstract：:Although epithelial to mesenchymal transitions (EMT) are often viewed as a unique event, they are characterized by a great diversity of cellular processes resulting in strikingly different outcomes. They may be complete or partial, massive or progressive, and lead to the complete disruption of the epithelium or leave ...

journal_title：Cell adhesion & migration

authors： Duband JL

更新日期：2010-07-01 00:00:00

abstract：:Growth factors regulate a diverse array of cellular functions including proliferation, survival, movement, and the ability to do this often involves interactions with the extracellular matrix (ECM) and particularly heparan sulfate proteoglycans (HSPGs). HSPGs have been shown to sequester growth factors, and to act as ...

journal_title：Cell adhesion & migration

authors： Symes K,Smith EM,Mitsi M,Nugent MA

更新日期：2010-10-01 00:00:00

abstract：:Acute mountain sickness (AMS) can cause capillary hyper-permeability and vasogenic edema. However, its underlying mechanisms remained unclear and there is no previous in vitro study on AMS. We therefore conducted an in vitro study and examined whether continuous hypobaric hypoxia (CHH) could alter expression of juncti...

journal_title：Cell adhesion & migration

authors： Souvannakitti D,Peerapen P,Thongboonkerd V

更新日期：2017-07-04 00:00:00

abstract：:Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This m...

journal_title：Cell adhesion & migration

authors： Gupta M,Doss B,Lim CT,Voituriez R,Ladoux B

更新日期：2016-09-02 00:00:00

abstract：:Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the g...

journal_title：Cell adhesion & migration

authors： Silva JF,Serakides R

更新日期：2016-03-03 00:00:00

abstract：:Over 20 years ago, protrusive, F-actin-based membrane structures, termed invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia penetrate artificial or explanted extracellular matrices in 2D culture conditions and have been hypothesized to facilitate the migration of cancer cells through base...

journal_title：Cell adhesion & migration

authors： Lohmer LL,Kelley LC,Hagedorn EJ,Sherwood DR

更新日期：2014-01-01 00:00:00