Abstract:
:Vinculin helps cells regulate and respond to mechanical forces. It is a scaffolding protein that tightly regulates its interactions with potential binding partners within adhesive structures-including focal adhesions that link the cell to the extracellular matrix and adherens junctions that link cells to each other-that physically connect the force-generating actin cytoskeleton (CSK) with the extracellular environment. This tight control of binding partner interaction-mediated by vinculin's autoinhibitory head-tail interaction-allows vinculin to rapidly interact and detach in response to changes in the dynamic forces applied through the cell. In doing so, vinculin modulates the structural composition of focal adhesions and the cell's ability to generate traction forces and adhesion strength. Recent evidence suggests that vinculin plays a similar role in regulating the fate and function of cell-cell junctions, further underscoring the importance of this protein. Using our lab's recent work as a starting point, this commentary explores several outstanding questions regarding the nature of vinculin activation and its function within focal adhesions and adherens junctions.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Dumbauld DW,García AJdoi
10.4161/cam.29139subject
Has Abstractpub_date
2014-01-01 00:00:00pages
550-7issue
6eissn
1933-6918issn
1933-6926journal_volume
8pub_type
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