Abstract：
:Despite high efficacy rates, significant costs and logistical challenges associated with procuring stool from healthy donors for fecal microbiota transplantation (FMT) have presented barriers to broader institutional adoption and limited the availability of this life-saving treatment. Published outcomes for donor screening programs report donor deferral rates between 90% and 96%. Due to the paucity of FMT donor screening data, a secondary analysis on a cohort of previously screened donors (n = 7,968) was conducted to provide a synopsis of the observed trends and rationales for prospective stool donor deferrals. Upon completion of the evaluation, 1.7% of prospective donors (n = 134) qualified for stool donation. Over 50% of donors who completed the online pre-screen were deferred, primarily for a body mass index of 30 kg/m2 or greater (n = 1,516, 37.0%), logistics (n = 841, 20.5%), and travel history (n = 638, 15.5%). Despite pre-screening, 569 donors (72.8%) who completed the in-person clinical assessment were ultimately deferred due primarily to potentially microbiome-mediated diseases (n = 187, 32.9%). A notably small portion of donors (n = 46, 25.6%) were deferred during the laboratory assessment process suggesting the clinical assessment was effective at deferring donors at higher risk for transmissible diseases. Donors lost to follow-up throughout the screening process presented a significant challenge and contributed to a notable (n = 3,117; 39.1%) portion of donor attrition. Findings were used to support recommendations for improving prospective stool donor screening programs and to provide suggestions for future research.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Dubois NE,Read CY,O'Brien K,Ling Kdoi
10.1177/1099800420941185subject
Has Abstractpub_date
2021-01-01 00:00:00pages
21-30issue
1eissn
1099-8004issn
1552-4175journal_volume
23pub_type
杂志文章abstract：RESULTS:hs-CRP correlated significantly with SLEDAI-2K (p = .036), SDI (p = .00), anti-dsDNA titers (p = .034), diabetes (p = .005), and obesity (p = .027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p = .032 and p < .001, respectively), TG/high-density lipoprotein cholesterol index (p = .020 and p = .001...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800419889192
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:The objectives of this study were to determine the change in gene expression between two time points following stroke and to identify biomarkers of stroke recovery through gene expression profiling and pathway analysis. METHODS:Peripheral blood was collected from 34 ischemic stroke patients (confirmed by ma...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414546492
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal cha...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420959721
更新日期：2020-09-22 00:00:00
abstract：:Caring, a core tenet of nursing practice, grew out of a holistic approach. Nurse theorists often note the establishment of a therapeutic relationship as the beginning point of caring, with subsequent nursing interventions reliant upon this relationship for effectiveness. Relational exchange serves as a source of eithe...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412450505
更新日期：2012-10-01 00:00:00
abstract：:Current medical technology permits the early detection of risk factors for coronary artery disease (CAD) in adults, and interventions are available to prevent CAD-related morbidity and mortality. The goal of this study was to determine the effectiveness of a Qigong exercise intervention in improving biomarker levels a...
journal_title：Biological research for nursing
pub_type： 杂志文章,随机对照试验
doi：10.1177/1099800415617017
更新日期：2016-05-01 00:00:00
abstract：:Multiple chemical sensitivity (MCS) is a chronic condition prevalent in women; the symptoms are reproducible with repeated low-level chemical exposure. Evidence gathered through clinical observations suggests that women with MCS may be at risk for autonomic nervous system dysfunction as evidenced by abnormal heart rat...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800408324251
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Many chronic conditions, including heart disease, cancer, and rheumatoid arthritis, are associated with underlying chronic inflammatory processes. Literature reviews have analyzed a variety of integrative therapies and their relationships with chronic inflammation. This systematic review is unique in reporti...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800418820162
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:This study examined adherence to a personalized, community-based exercise intervention by sedentary adolescents with type 1 or type 2 diabetes or those with obesity. RESEARCH DESIGN AND METHODS:We conducted a pretest-posttest investigation to explore the application of an individualized exercise prescription...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413500064
更新日期：2014-01-01 00:00:00
abstract：:African American (AA) women are nearly twice as likely as non-Hispanic White (NHW) women to develop atherosclerosis associated with cardiovascular disease. Compelling evidence demonstrates that stress-related biomarkers, such as heat shock protein-70 (HSP70), are associated with increased atherosclerosis risk. Yet lit...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413491422
更新日期：2014-07-01 00:00:00
abstract：:Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mech...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040100200304
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Incidence rates of both type 1 and type 2 diabetes mellitus (DM) are increasing in youth and may eventually contribute to premature heart disease in early adulthood. This investigation explored the influence of type of diabetes, gender, body mass index (BMI), metabolic control (HbA1c), exercise beliefs and p...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800405275202
更新日期：2005-07-01 00:00:00
abstract：AIM:The purpose of this paper is to review the techniques and implications of laser capture microdissection (LCM) to isolate tissue and DNA of interest using breast biopsy tissue as an example. BACKGROUND:Tissues are a heterogeneous mix of different cell types, and molecular alterations are often specific to a single ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411402054
更新日期：2011-07-01 00:00:00
abstract：:Benefits of daily physical activity are well known, but there are limited data to describe physical activity in heart failure patients who receive cardiac resynchronization therapy devices. The purpose of this pilot study was to evaluate changes in physical activity (PA) levels before and 3 months after Cardiac Resync...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413481619
更新日期：2014-01-01 00:00:00
abstract：:The purpose of this pilot study was to investigate selected stress, immune, and growth consequences of maternal separation and separation with supplemental stroking in neonatal BALB/c infant mice and their dams. Three groups of 5 litters each (7 pups per litter) were studied. Control litters were undisturbed. Separate...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800402003003002
更新日期：2002-01-01 00:00:00
abstract：:People with schizophrenia have a higher prevalence of obesity than the general population. Many people with this illness struggle with weight gain, due, in part, to medications and other factors that act as obstacles to exercise and healthy eating. Several studies have shown the benefits of behavioral weight loss prog...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410393272
更新日期：2011-10-01 00:00:00
abstract：:Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413501717
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:In recent years, researchers have noted an "obesity paradox," where individuals with obesity survive sepsis at higher rates than their nonobese counterparts. This systematic review summarizes the literature on studies examining the association between obesity and 1-year mortality among patients admitted with se...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800419876070
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Diabetes is a serious health problem affecting approximately 29.1 million individuals in the United States. Another 86 million have prediabetes. The development and implementation of lifestyle modifications such as physical activity for these persons are among the most effective methods for prevention and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800418767572
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:Activity restriction (AR), one of the most common interventions used in high-risk pregnancies, may exacerbate loss of bone mass. The purpose of this study was to determine changes over time in bone resorption in hospitalized AR women during late pregnancy. METHODS:This was a short-term prospective study conduc...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412463120
更新日期：2014-01-01 00:00:00
abstract：:Self-management programs that include cognitive behavioral strategies have been shown to improve gastrointestinal (GI) symptoms, psychological distress, and quality of life (QoL) in persons with irritable bowel syndrome (IBS). However, less is known about the physiological impact of such a change. As part of a randomi...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411414047
更新日期：2013-01-01 00:00:00
abstract：:Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800411402494
更新日期：2011-07-01 00:00:00
abstract：:MicroRNAs (miRs) are epigenetic regulators of messenger RNAs' (mRNA) expression of polypeptides. As such, miRs represent an intriguing mechanism by which gene-environment interactions are hypothesized to occur on the level of epigenetic control over gene expression. In addition to promising findings from in vitro stud...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800411430380
更新日期：2013-04-01 00:00:00
abstract：:Depression increases the risk of adverse cardiac events. Cardiovascular reactivity is defined as the pattern of cardiovascular responses to mental stress. An altered pattern of cardiovascular reactivity is an indicator of subsequent cardiovascular disease. Because depression and adverse cardiac events may have a dose-...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800415596227
更新日期：2016-03-01 00:00:00
abstract：:The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions fr...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800409341175
更新日期：2010-01-01 00:00:00
abstract：:During the menopausal transition and early postmenopause, participants in the Seattle Midlife Women's Health Study (SMWHS) experienced one of the three symptom severity clusters identified through latent class analysis: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (high-severity hot flash...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417753536
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:There are documented associations between elevated maternal corticotropin-releasing hormone (CRH) levels and adverse pregnancy outcomes. However, reports of these findings often lack sufficient detail and rationale regarding the bioassay methodology. This shortcoming can be problematic for researchers who do...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800408320970
更新日期：2008-07-01 00:00:00
abstract：:This article explores ethical concerns and emerging dilemmas associated with the proliferation of information resulting from the extraordinary advances in molecular genetics. It provides an overview of the ethical and legal challenges associated with predictive testing for inherited disease currently being addressed i...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040100300104
更新日期：2001-07-01 00:00:00
abstract：:Cytokines are small signaling proteins released from a variety of cells that influence virtually every aspect of growth and development and every host response to infection, injury, and inflammation. Because of their widespread and potent effects across the life span, cytokines without a doubt influence nursing resear...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040000200105
更新日期：2000-07-01 00:00:00
abstract：:The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers who smoke cigarettes. An experimental des...
journal_title：Biological research for nursing
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/1099800406290643
更新日期：2006-10-01 00:00:00
abstract：:Cancer-related fatigue (CRF) is a multifactorial, biobehavioral phenomenon experienced by the majority of persons with cancer. It has negative consequences on the individual's physical functioning and quality of life. An array of biological, psychobehavioral, and functional mechanisms contributes to its occurrence. A ...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800408324431
更新日期：2009-04-01 00:00:00
