Abstract：
:The purpose of this pilot study was to investigate selected stress, immune, and growth consequences of maternal separation and separation with supplemental stroking in neonatal BALB/c infant mice and their dams. Three groups of 5 litters each (7 pups per litter) were studied. Control litters were undisturbed. Separated litters experienced 3 h of daily maternal deprivation on postnatal days 6 to 10. Separated/stroked litters were separated also, but for 2 h, which was then followed by 1 h of stroking with a wet paintbrush to simulate maternal tactile stimulation. After the experimental period, all animals were returned to the nest and left undisturbed for 5 additional days. One pup from each litter was sacrificed on postnatal days 6, 8, 10, and 15. Spleens and thymuses were removed, weighed, and homogenized for cell sorting, cytokine analysis, and proliferation studies. Blood was drawn for corticosterone levels and hematocrit. Hematocrits and thymus weights were lower in separated mice, suggesting decreased growth and protein synthesis. Separated/stroked pups had increased splenic proliferation responses to conconavalin A and phytohemagglutinin at day 15. Separated dams' proliferative response to ConA was lower than control dams at day 15. Day 15 decreases in thymic CD8 cells occurred in pups, with an increased thymic H:S ratio in separated pups. CD90 cells were higher at day 15 in separated/stroked pups as were CD25s at day 10 in spleen and thymus. However, gene expression of cytokines was not measurable in spleen and thymic cells, with the exception of gamma-IFN in separated/stroked animals. Pooled organ homogenates were used in this preliminary work, and further studies are needed to more precisely analyze the stress, immune, and growth effects of these interventions.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Groër MW,Hill J,Wilkinson JE,Stuart Adoi
10.1177/1099800402003003002subject
Has Abstractpub_date
2002-01-01 00:00:00pages
119-31issue
3eissn
1099-8004issn
1552-4175journal_volume
3pub_type
杂志文章abstract：:Society has a rapidly growing accumulative sleep debt due to employment obligations and lifestyle choices that limit sleep opportunities. The degree to which poor sleep may set the stage for adverse symptom outcomes among more than 1.7 million persons who will be diagnosed with cancer is not entirely understood. Pacli...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414539385
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417702742
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal cha...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420959721
更新日期：2020-09-22 00:00:00
abstract：:The purpose of this study was to compare physiological and psychological reactions among Taiwanese women with different degrees of severity of nausea and vomiting (NV) during pregnancy. Based on their scores on the Index of Nausea, Vomiting, and Retching (INVR), 59 pregnant women ≥ 18 years of age, with single gestati...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410388506
更新日期：2011-10-01 00:00:00
abstract：:Bidirectional communication between the immune system and the brain and the implications of this communication are emerging concepts in pain research. Although representing a small portion of the disc degeneration syndromes, lumbar herniated discs can cause significant symptoms that may persist even after surgical int...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800404272221
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:There are documented associations between elevated maternal corticotropin-releasing hormone (CRH) levels and adverse pregnancy outcomes. However, reports of these findings often lack sufficient detail and rationale regarding the bioassay methodology. This shortcoming can be problematic for researchers who do...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800408320970
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Application of a thermal stimulus is a common procedure used to promote venodilation for peripheral intravenous cannulation (PIVC); however, the effects of thermal stimulation on the duration of venodilation and skin temperature of the forearm are unclear. AIM:To investigate the duration of venodilation ind...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416651145
更新日期：2017-03-01 00:00:00
abstract：:Cytokines are small signaling proteins released from a variety of cells that influence virtually every aspect of growth and development and every host response to infection, injury, and inflammation. Because of their widespread and potent effects across the life span, cytokines without a doubt influence nursing resear...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040000200105
更新日期：2000-07-01 00:00:00
abstract：:Cytokines such as angiogenin (ANG) and interleukin (IL-8) have been shown to be related to depressive symptoms and inflammatory diseases like coronary heart disease. They may thus be used as stress biomarkers to identify and prevent health problems. To investigate the relationship between cytokines and nurses' job-rel...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800408323219
更新日期：2008-10-01 00:00:00
abstract：:The primary purpose of this exploratory study was to compare percentages of natural killer (NK) cells and activated NK and T cells, and both cytotoxic and in vitro cytokine production activity in women with and without symptomatic irritable bowel syndrome (IBS). A secondary purpose was to examine the relationships of ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800402004001005
更新日期：2002-07-01 00:00:00
abstract：:To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures incl...
journal_title：Biological research for nursing
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/1099800403005001005
更新日期：2003-07-01 00:00:00
abstract：:The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, while antiedematogenic ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800409343311
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:The Finnmarksløpet dogsled race lasts up to 7 days. Helpers, who keep time, coach, and transport equipment, have to be alert though they have little and fragmented sleep. This study investigated disruptions of the rest-activity rhythm among helpers. METHODS:10 helpers were monitored by actigraph a week befor...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412475077
更新日期：2014-04-01 00:00:00
abstract：AIM:The purpose of this paper is to review the techniques and implications of laser capture microdissection (LCM) to isolate tissue and DNA of interest using breast biopsy tissue as an example. BACKGROUND:Tissues are a heterogeneous mix of different cell types, and molecular alterations are often specific to a single ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411402054
更新日期：2011-07-01 00:00:00
abstract：:Paclitaxel (PAC) treatment is associated with persistent, debilitating neuropathic pain that affects the hands and feet. Female sex and biological stress responsivity are risk factors for persistent pain, but it is unclear whether these important biologically based factors confer risk for PAC-induced neuropathic pain....
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800415609418
更新日期：2016-05-01 00:00:00
abstract：:African American (AA) women are nearly twice as likely as non-Hispanic White (NHW) women to develop atherosclerosis associated with cardiovascular disease. Compelling evidence demonstrates that stress-related biomarkers, such as heat shock protein-70 (HSP70), are associated with increased atherosclerosis risk. Yet lit...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413491422
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:The most consistently replicated genetic variants associated with coronary heart disease (CHD) in populations of European descent have been found on chromosome 9p21. Yet there is little known about these associations in ethnic groups of African ancestry. These disease-associated variants are located in a gen...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411403469
更新日期：2011-07-01 00:00:00
abstract：:Depression increases the risk of adverse cardiac events. Cardiovascular reactivity is defined as the pattern of cardiovascular responses to mental stress. An altered pattern of cardiovascular reactivity is an indicator of subsequent cardiovascular disease. Because depression and adverse cardiac events may have a dose-...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800415596227
更新日期：2016-03-01 00:00:00
abstract：:The psychophysiological phenomenon of pain is of tremendous concern to nurses because of its potential to adversely affect the mental, emotional, and physical health of patients. Increasingly appreciated is the ability of pain to influence immune variables including enumerative and functional measures of leukocyte sub...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800405286071
更新日期：2006-04-01 00:00:00
abstract：:Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414532710
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417752246
更新日期：2018-03-01 00:00:00
abstract：:The prevalence of obesity and obesity-related illnesses is higher among Hispanics (Latinos) than other racial and ethnic groups, and rates increase exponentially with the number of years living in the United States. Mounting evidence suggests that the origins of many chronic illnesses among disadvantaged minority grou...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800412457017
更新日期：2012-10-01 00:00:00
abstract：:Sickness behavior is a cluster of symptoms that occur as a response to an infection and alterations in the inflammatory response. Under normal circumstances, sickness behavior is fully reversible once the pathogen has been cleared. Aging and chronic illness such as heart failure are associated with enhanced inflammato...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412466170
更新日期：2014-01-01 00:00:00
abstract：:Multiple chemical sensitivity (MCS) is a chronic condition prevalent in women; the symptoms are reproducible with repeated low-level chemical exposure. Evidence gathered through clinical observations suggests that women with MCS may be at risk for autonomic nervous system dysfunction as evidenced by abnormal heart rat...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800408324251
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. METHODS:This cross-sectional study included 976 adolescent...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416648207
更新日期：2016-10-01 00:00:00
abstract：:Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mech...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040100200304
更新日期：2001-01-01 00:00:00
abstract：:The theoretical constructs of allostasis and allostatic load (AL) have contributed to our understanding of how constantly changing social and environmental factors impact physiological functioning and shape health and aging disparities, particularly along socioeconomic, gendered, racial, and ethnic lines. AL represent...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800412455688
更新日期：2012-10-01 00:00:00
abstract：:Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413501717
更新日期：2014-01-01 00:00:00
abstract：:Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800411402494
更新日期：2011-07-01 00:00:00
abstract：:The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions fr...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800409341175
更新日期：2010-01-01 00:00:00
