Abstract:
:This article explores ethical concerns and emerging dilemmas associated with the proliferation of information resulting from the extraordinary advances in molecular genetics. It provides an overview of the ethical and legal challenges associated with predictive testing for inherited disease currently being addressed in the literature. Finally, it offers a framework of ethical principles that can be used to guide nurses and other practitioners in the appropriate application of research findings to the clinical practice setting. The ethical guidelines of self-determination, benefit-burden ratio, and justice promulgated in The Belmont Report are interpreted in the new context of predictive genetic testing. The author concludes by discussing how to balance the technical imperative to advance genetic knowledge for the sake of human health with the ethical imperative to preserve the fundamental rights and liberties of both individuals and communities who are its recipients.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Carter MAdoi
10.1177/109980040100300104subject
Has Abstractpub_date
2001-07-01 00:00:00pages
24-32issue
1eissn
1099-8004issn
1552-4175journal_volume
3pub_type
杂志文章,评审abstract::African American (AA) women are nearly twice as likely as non-Hispanic White (NHW) women to develop atherosclerosis associated with cardiovascular disease. Compelling evidence demonstrates that stress-related biomarkers, such as heat shock protein-70 (HSP70), are associated with increased atherosclerosis risk. Yet lit...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800413491422
更新日期:2014-07-01 00:00:00
abstract::Military personnel experience posttraumatic stress disorder (PTSD), which is associated with differential DNA methylation across the whole genome. However, the relationship between these DNA methylation patterns and clinically relevant increases in PTSD severity is not yet clearly understood. The purpose of this study...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418758951
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417752246
更新日期:2018-03-01 00:00:00
abstract::Listening to soothing music has been used as a complementary therapy to improve sleep quality. However, there is no empirical evidence for the effects of music videos (MVs) on sleep quality in adults with insomnia as assessed by polysomnography (PSG). In this randomized crossover controlled trial, we compared the effe...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800414549237
更新日期:2015-05-01 00:00:00
abstract::The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers who smoke cigarettes. An experimental des...
journal_title:Biological research for nursing
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1099800406290643
更新日期:2006-10-01 00:00:00
abstract::The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414534313
更新日期:2015-03-01 00:00:00
abstract::Shift work schedules, intensive physical exercise late in the day, psychological stress, or a busy lifestyle might induce disorders of the circadian structure, which can affect health on both the physiological and neurobehavioral levels. Rest-activity rhythm is strongly connected with an organism's circadian structure...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411416224
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Activity restriction (AR), one of the most common interventions used in high-risk pregnancies, may exacerbate loss of bone mass. The purpose of this study was to determine changes over time in bone resorption in hospitalized AR women during late pregnancy. METHODS:This was a short-term prospective study conduc...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800412463120
更新日期:2014-01-01 00:00:00
abstract::The purpose of this study was to describe the sleep patterns and fatigue of both mothers and fathers before and after childbirth. The authors used wrist actigraphy and questionnaires to estimate sleep and fatigue in 72 couples during their last month of pregnancy and 1st month postpartum. Both parents experienced more...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800403262142
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGB) is considered the gold standard for gastric bypass, displaying better results for metabolic disorders than other surgical procedures over the long term. The aim of this study was to determine the effects of bariatric surgery, in particular the RYGB technique, on metabolic synd...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416675406
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to explore gene expression changes in fatigued men with nonmetastatic prostate cancer receiving localized external beam radiation therapy (EBRT). METHODS:Fatigue was measured in 40 men with prostate cancer (20 receiving EBRT and 20 controls on active surveillance) using the Functi...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800415618786
更新日期:2016-05-01 00:00:00
abstract::Preterm birth (PTB; spontaneous delivery prior to 37 weeks gestation) affects one out of eight infants born in the United States and is the most common cause of neonatal morbidity and mortality. Although the pathogenesis of PTB is multifactorial, a growing body of literature supports the hypothesis that one cause of P...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800409344620
更新日期:2010-04-01 00:00:00
abstract::The psychophysiological phenomenon of pain is of tremendous concern to nurses because of its potential to adversely affect the mental, emotional, and physical health of patients. Increasingly appreciated is the ability of pain to influence immune variables including enumerative and functional measures of leukocyte sub...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800405286071
更新日期:2006-04-01 00:00:00
abstract::Age-related changes in skeletal muscle, in combination with bed rest, may result in a poorer rehabilitation potential for an elderly patient. The purpose of this study was to determine the effects of non-weight bearing (hind limb unweighting [HU]) on the soleus and extensor digitorum longus (EDL) in older rats. Two no...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800403260693
更新日期:2004-01-01 00:00:00
abstract::The purpose of this study was to examine whether the hepatitis B seroconversion rates in a small sample of subjects reflected that of the published rates, regardless of HIV status, after a hepatitis B vaccination series was completed while following strict vaccine protocols. The study, which had a nonexperimental, cor...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414524619
更新日期:2015-01-01 00:00:00
abstract::Nausea and vomiting are the most common side effects of antineoplastic chemotherapy. However, only a small number of studies have been conducted in Taiwan to determine the efficacy of acupressure in treating these side effects in cancer patients receiving chemotherapy. In this quasi-experimental study, we aimed to exp...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416683801
更新日期:2017-03-01 00:00:00
abstract::The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/109980040000100408
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:We examined genomic variation potentially associated with the cortisol stress response in children having a painful medical procedure. DESIGN:Children 4-10 years old having a peripheral intravenous line inserted provided saliva samples for evaluation of the cortisol response as a biological measure of distre...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419826315
更新日期:2019-03-01 00:00:00
abstract::Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417746504
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The Finnmarksløpet dogsled race lasts up to 7 days. Helpers, who keep time, coach, and transport equipment, have to be alert though they have little and fragmented sleep. This study investigated disruptions of the rest-activity rhythm among helpers. METHODS:10 helpers were monitored by actigraph a week befor...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800412475077
更新日期:2014-04-01 00:00:00
abstract::The prevalence of vascular dementia continues to increase with no cure. Thus, it is important identify the aggravating factors of vascular dementia to delay disease progression in patients. Obesity is a well-known risk factor for vascular dementia and causes mild cognitive impairment. In the present study, we evaluate...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420951633
更新日期:2020-08-26 00:00:00
abstract::The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reducti...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418772907
更新日期:2018-07-01 00:00:00
abstract::Postpartum depression (PPD) affects at least 10% to 15% of postpartum women, including more than 600,000 American mothers in 2003 alone. Dramatic changes in the hypothalamic-pituitary-adrenal (HPA) system in the transition from pregnancy to postpartum coupled with research on the psychobiology of depression provided t...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800406294598
更新日期:2007-01-01 00:00:00
abstract::To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures incl...
journal_title:Biological research for nursing
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/1099800403005001005
更新日期:2003-07-01 00:00:00
abstract::Self-management programs that include cognitive behavioral strategies have been shown to improve gastrointestinal (GI) symptoms, psychological distress, and quality of life (QoL) in persons with irritable bowel syndrome (IBS). However, less is known about the physiological impact of such a change. As part of a randomi...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411414047
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Many chronic conditions, including heart disease, cancer, and rheumatoid arthritis, are associated with underlying chronic inflammatory processes. Literature reviews have analyzed a variety of integrative therapies and their relationships with chronic inflammation. This systematic review is unique in reporti...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418820162
更新日期:2019-03-01 00:00:00
abstract::Despite high efficacy rates, significant costs and logistical challenges associated with procuring stool from healthy donors for fecal microbiota transplantation (FMT) have presented barriers to broader institutional adoption and limited the availability of this life-saving treatment. Published outcomes for donor scre...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420941185
更新日期:2021-01-01 00:00:00
abstract::Delirium is a serious complication of acute illness. Little is known, however, regarding the neurobiology of delirium, largely due to challenges in studying the complex inpatient population. Neuroimaging is one noninvasive method that can be used to study structural and functional brain abnormalities associated with d...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800419849489
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure. STUDY DESIGN:Children aged 4-10 years having an IV catheter insertion were recruited from three Midwestern children's hospitals. Self-report measures ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417692878
更新日期:2017-05-01 00:00:00
abstract::Cytokines such as angiogenin (ANG) and interleukin (IL-8) have been shown to be related to depressive symptoms and inflammatory diseases like coronary heart disease. They may thus be used as stress biomarkers to identify and prevent health problems. To investigate the relationship between cytokines and nurses' job-rel...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800408323219
更新日期:2008-10-01 00:00:00