Abstract:
:Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody to its antigen. Scientists continue to develop new methodologies, such as high-throughput immunohistochemistry (IHC) and in vivo imaging techniques, which exploit antibody-antigen binding, to more accurately answer complex research questions involving single cells up to whole organ systems. The purpose of this paper is to discuss established and evolving IMs and to illustrate the application of these methods to nursing research.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Morrison HW,Downs CAdoi
10.1177/1099800411402494subject
Has Abstractpub_date
2011-07-01 00:00:00pages
227-34issue
3eissn
1099-8004issn
1552-4175pii
1099800411402494journal_volume
13pub_type
杂志文章,评审abstract::To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures incl...
journal_title:Biological research for nursing
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/1099800403005001005
更新日期:2003-07-01 00:00:00
abstract::The prevalence of vascular dementia continues to increase with no cure. Thus, it is important identify the aggravating factors of vascular dementia to delay disease progression in patients. Obesity is a well-known risk factor for vascular dementia and causes mild cognitive impairment. In the present study, we evaluate...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420951633
更新日期:2020-08-26 00:00:00
abstract::Depression increases the risk of adverse cardiac events. Cardiovascular reactivity is defined as the pattern of cardiovascular responses to mental stress. An altered pattern of cardiovascular reactivity is an indicator of subsequent cardiovascular disease. Because depression and adverse cardiac events may have a dose-...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800415596227
更新日期:2016-03-01 00:00:00
abstract::For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar sym...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800417751069
更新日期:2018-03-01 00:00:00
abstract::Adolescence is considered a critical period for risk of depressive symptoms, with prevalence ranging from 13% to 34%. Few studies have examined the relationships among perceived stress, bullying, and depressive symptoms accompanied by a biological marker of stress (cortisol). The purpose of this pilot study was to det...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416656396
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions fr...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800409341175
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Proinflammatory activity has been suggested as one of the psychophysiological mechanisms responsible for the health risks associated with stress and mood disorders. There have been limited studies evaluating central immune and hypothalamic- pituitary-adrenal (HPA) axis responses to experimental stress in heal...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410383558
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:Sleep deficit affects neurobehavioral functioning, reduces attention and cognitive function, and negatively impacts occupational safety. This study investigated selective attention levels of nursing staff on different shifts. METHODS:Using a prospective, randomized parallel group study, selective attention was...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800412445907
更新日期:2013-10-01 00:00:00
abstract::The purpose of this study was to compare physiological and psychological reactions among Taiwanese women with different degrees of severity of nausea and vomiting (NV) during pregnancy. Based on their scores on the Index of Nausea, Vomiting, and Retching (INVR), 59 pregnant women ≥ 18 years of age, with single gestati...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410388506
更新日期:2011-10-01 00:00:00
abstract::Interpretation of changes in health and health care utilization patterns across the life span depends on an understanding of the effects of age, period, and cohort. The purpose of this article is to illustrate differences among three generations of women in demographic factors, health risk factors, and health status i...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410373804
更新日期:2010-10-01 00:00:00
abstract::Central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia, used to prevent disease recurrence in the brain, is essential for survival. Systemic and intrathecal methotrexate, commonly used for CNS-directed treatment, have been associated with cognitive problems during and after treatment. The cor...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416644780
更新日期:2016-10-01 00:00:00
abstract::Sickness behavior is a cluster of symptoms that occur as a response to an infection and alterations in the inflammatory response. Under normal circumstances, sickness behavior is fully reversible once the pathogen has been cleared. Aging and chronic illness such as heart failure are associated with enhanced inflammato...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800412466170
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure. STUDY DESIGN:Children aged 4-10 years having an IV catheter insertion were recruited from three Midwestern children's hospitals. Self-report measures ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417692878
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Drug addiction is a multifactorial disorder. Researchers have posited that an individual's inherited behavioral propensity or temperament contributes to the disorder by shaping a personality strongly linked with the risk of drug abuse. Further, they hypothesize that the polymorphism of dopamine D2 receptor i...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411405030
更新日期:2012-04-01 00:00:00
abstract::People with schizophrenia have a higher prevalence of obesity than the general population. Many people with this illness struggle with weight gain, due, in part, to medications and other factors that act as obstacles to exercise and healthy eating. Several studies have shown the benefits of behavioral weight loss prog...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410393272
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:There are documented associations between elevated maternal corticotropin-releasing hormone (CRH) levels and adverse pregnancy outcomes. However, reports of these findings often lack sufficient detail and rationale regarding the bioassay methodology. This shortcoming can be problematic for researchers who do...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800408320970
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGB) is considered the gold standard for gastric bypass, displaying better results for metabolic disorders than other surgical procedures over the long term. The aim of this study was to determine the effects of bariatric surgery, in particular the RYGB technique, on metabolic synd...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416675406
更新日期:2017-03-01 00:00:00
abstract::Cancer-related fatigue (CRF) is a multifactorial, biobehavioral phenomenon experienced by the majority of persons with cancer. It has negative consequences on the individual's physical functioning and quality of life. An array of biological, psychobehavioral, and functional mechanisms contributes to its occurrence. A ...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800408324431
更新日期:2009-04-01 00:00:00
abstract::Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417746504
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Incidence rates of both type 1 and type 2 diabetes mellitus (DM) are increasing in youth and may eventually contribute to premature heart disease in early adulthood. This investigation explored the influence of type of diabetes, gender, body mass index (BMI), metabolic control (HbA1c), exercise beliefs and p...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800405275202
更新日期:2005-07-01 00:00:00
abstract::Benefits of daily physical activity are well known, but there are limited data to describe physical activity in heart failure patients who receive cardiac resynchronization therapy devices. The purpose of this pilot study was to evaluate changes in physical activity (PA) levels before and 3 months after Cardiac Resync...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800413481619
更新日期:2014-01-01 00:00:00
abstract:RESULTS:hs-CRP correlated significantly with SLEDAI-2K (p = .036), SDI (p = .00), anti-dsDNA titers (p = .034), diabetes (p = .005), and obesity (p = .027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p = .032 and p < .001, respectively), TG/high-density lipoprotein cholesterol index (p = .020 and p = .001...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419889192
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Application of a thermal stimulus is a common procedure used to promote venodilation for peripheral intravenous cannulation (PIVC); however, the effects of thermal stimulation on the duration of venodilation and skin temperature of the forearm are unclear. AIM:To investigate the duration of venodilation ind...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416651145
更新日期:2017-03-01 00:00:00
abstract::The purposes of this quasi-experimental pilot study were to determine adherence to a 12-week group-based moderate-intensity walking program for sedentary adult outpatients with serious and persistent mental illness and to examine change from baseline to after the walking program in health status (mental and physical h...
journal_title:Biological research for nursing
pub_type: 临床试验,杂志文章
doi:10.1177/1099800405278116
更新日期:2005-10-01 00:00:00
abstract::The purpose of this study was to describe the sleep patterns and fatigue of both mothers and fathers before and after childbirth. The authors used wrist actigraphy and questionnaires to estimate sleep and fatigue in 72 couples during their last month of pregnancy and 1st month postpartum. Both parents experienced more...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800403262142
更新日期:2004-04-01 00:00:00
abstract::Nausea and vomiting are the most common side effects of antineoplastic chemotherapy. However, only a small number of studies have been conducted in Taiwan to determine the efficacy of acupressure in treating these side effects in cancer patients receiving chemotherapy. In this quasi-experimental study, we aimed to exp...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416683801
更新日期:2017-03-01 00:00:00
abstract::Multiple chemical sensitivity (MCS) is a chronic condition prevalent in women; the symptoms are reproducible with repeated low-level chemical exposure. Evidence gathered through clinical observations suggests that women with MCS may be at risk for autonomic nervous system dysfunction as evidenced by abnormal heart rat...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800408324251
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:To report the complexity and richness of study variables within biological nursing research, authors often use tables; however, the ease with which consumers understand, synthesize, evaluate, and build upon findings depends partly upon table design. OBJECTIVES:To assess and compare table characteristics wit...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417724901
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Our program of research focuses on thermal and circulatory stability in extremely premature infants. In prior studies, we found that infants have long periods of time in which foot temperature (FT) is higher than central temperature. We thus wanted to determine whether blood flow in the foot is increased whe...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416656914
更新日期:2017-01-01 00:00:00
abstract::Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800413501717
更新日期:2014-01-01 00:00:00