Abstract：
:Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model system for studying AVC development, and much progress has been made in dissecting out the critical steps. Here, we review the recent advances in the field and highlight the cellular and molecular changes observed during zebrafish AVC development.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Peal DS,Lynch SN,Milan DJdoi
10.1007/s12265-011-9313-zsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
720-6issue
6eissn
1937-5387issn
1937-5395journal_volume
4pub_type
杂志文章,评审abstract：:Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explo...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-09978-3
更新日期：2020-03-24 00:00:00
abstract：:Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction (STEMI) despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a b...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12265-016-9691-3
更新日期：2016-06-01 00:00:00
abstract：:Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvi...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9198-2
更新日期：2010-12-01 00:00:00
abstract：:Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that are endogenous transcripts generated from linear precursor mRNA through a backsplicing mechanism. With the development of high-throughput sequencing technology, a number of circRNAs have been identified and proved to play key rol...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-019-09912-2
更新日期：2020-08-01 00:00:00
abstract：:Intercellular communication mediated by exosomes, nano-sized extracellular vesicles, is crucial for preserving vascular integrity and in the development of cardiovascular and other diseases. As natural carriers of signal molecules, exosomes released from sources such as blood cells, endothelial cells, immune cells, sm...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-016-9682-4
更新日期：2016-06-01 00:00:00
abstract：:The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples w...
journal_title：Journal of cardiovascular translational research
pub_type： 信件
doi：10.1007/s12265-017-9744-2
更新日期：2017-04-01 00:00:00
abstract：:With improved screening and the advent of many novel therapeutics, patients with cancer are living longer and often surviving their disease. Cardiovascular complications have significant impact on both short- and long-term morbidity and mortality in these patients. While a great deal of attention has been paid to card...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-019-09924-y
更新日期：2020-06-01 00:00:00
abstract：:It is becoming increasingly evident that poor nutrition plays an important role in inducing cardiovascular disease. Just as importantly, data now support the contention that appropriate nutritional interventions may have just as important an effect in preventing or delaying the appearance of cardiovascular disease. If...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-009-9116-7
更新日期：2009-09-01 00:00:00
abstract：:The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts w...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9856-3
更新日期：2019-08-01 00:00:00
abstract：:A number of genetic variants have been identified in the lipoprotein lipase (LPL) gene. We aimed to investigate the possible associations between LPL gene and apolipoprotein C3 (APOC3) gene polymorphisms with coronary artery disease (CAD) and its severity, as well as the interaction between these polymorphisms and cla...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-013-9446-3
更新日期：2013-06-01 00:00:00
abstract：:In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-10086-5
更新日期：2020-12-17 00:00:00
abstract：:Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the stud...
journal_title：Journal of cardiovascular translational research
pub_type： 评论,杂志文章
doi：10.1007/s12265-011-9306-y
更新日期：2011-10-01 00:00:00
abstract：:Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) a...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-013-9463-2
更新日期：2013-08-01 00:00:00
abstract：:The increase in cardiovascular disease and metabolic syndrome incidence following the onset of menopause has highlighted the role of estrogen as a cardiometabolic protective agent. Specifically regarding the heart, estrogen induced an improvement in cardiac function, preserved calcium homeostasis, and inhibited the mi...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-016-9675-3
更新日期：2016-02-01 00:00:00
abstract：:Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source o...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9184-8
更新日期：2010-08-01 00:00:00
abstract：:The advancement of pediatric medical devices is an important challenge currently facing the Food and Drug Administration and the medical community. In this manuscript, the challenges are described and possible solutions presented. ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-009-9100-2
更新日期：2009-06-01 00:00:00
abstract：:The pathophysiological abnormalities associated with increased arterial stiffness and/or abnormal pressure wave reflection may play crucial roles in increasing the risk of development of cardiovascular events. On the other hand, prehypertension, defined as a systolic blood pressure of 120-139 and/or a diastolic blood ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-011-9345-4
更新日期：2012-06-01 00:00:00
abstract：:Sympathoactivation is a prominent feature of heart failure (HF). Its role in cardiac remodeling and arrhythmogenesis is well-recognized today, although incomplete understanding of autonomic mechanisms was a barrier to development of contemporary medical therapies. Despite widespread availability of drugs and devices, ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-014-9546-8
更新日期：2014-04-01 00:00:00
abstract：:Acute pulmonary embolism (APE) is a common sudden venous thromboembolism with high rates of morbidity and mortality. Several studies have concluded that microRNA-134 could be a potential biomarker for APE. However, the sensitivity of these studies varies widely. This study aimed to evaluate the diagnostic value of cir...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-10087-4
更新日期：2021-01-06 00:00:00
abstract：:Although most cardiac cell therapy trials have focused on patients with acute myocardial infarction, attempts at "regenerating" chronically failing hearts have also been performed. These studies have entailed use of skeletal myoblasts and bone marrow-derived cells. In the case of skeletal myoblasts, the randomized pla...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-008-9017-1
更新日期：2008-09-01 00:00:00
abstract：:Across biomedicine, there is a major drive to develop stem cell (SC) treatments for debilitating diseases. Most effective treatments restore an embryonic phenotype to adult SCs. This has led to two emerging paradigms in SC biology: the application of developmental biology studies and the manipulation of the SC niche. ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-012-9386-3
更新日期：2012-10-01 00:00:00
abstract：:A previously developed poly-L-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch. Control groups were constituted by healthy, chronic MI and nonfunctionalized PLLA scaffold. PLLA-based electrospun scaffo...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-016-9718-9
更新日期：2017-02-01 00:00:00
abstract：:Comprehensive diagnostic criteria, accurate prognostic indicators, and effective treatment for patients with heart failure and a preserved ejection fraction (HFpEF) represent a critically important unmet need in cardiovascular medicine. Novel approaches to fill this unmet need are likely to be facilitated by targeting...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-013-9472-1
更新日期：2013-08-01 00:00:00
abstract：:Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated thei...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9857-2
更新日期：2019-08-01 00:00:00
abstract：:Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. The...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-017-9728-2
更新日期：2017-04-01 00:00:00
abstract：:The second messengers, cAMP and cGMP, regulate a number of physiological processes in the myocardium, from acute contraction/relaxation to chronic gene expression and cardiac structural remodeling. Emerging evidence suggests that multiple spatiotemporally distinct pools of cyclic nucleotides can discriminate specific ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9203-9
更新日期：2010-10-01 00:00:00
abstract：:Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing fa...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-012-9368-5
更新日期：2012-08-01 00:00:00
abstract：:Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phen...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-017-9753-1
更新日期：2017-08-01 00:00:00
abstract：:Chronotropic incompetence (CI) is common in heart failure (HF) patients and is associated with worsening outcome. Detecting and tracking functional CI during activities of daily living could provide insight into its contribution to HF symptoms and facilitate effective HF patient management. HF patients (n = 180, NYHA ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,多中心研究
doi：10.1007/s12265-010-9227-1
更新日期：2011-02-01 00:00:00
abstract：:The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify the epitopes of M5 protein that produce valvulitis, synthetic peptides spanning A, B, and C repeat regions contained within the extracellular dom...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-013-9526-4
更新日期：2014-03-01 00:00:00
