Abstract:
:Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explore the associations between Cer and culprit plaque characterizations evaluated by optical coherence tomography (OCT). It was found that plasma Cer are associated with culprit plaque vulnerability evaluated by OCT, providing evidence supporting proatherogenic roles and potential to act as markers for plaque vulnerability of Cer. Graphical Abstract With increasing plasma ceramide levels, the prevalence of thin-cap fibroatheroma (TCFA) and plaque rupture (PR) is higher, that is, culprit plaques are more vulnerable.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Pan W,Dong H,Sun R,Zhao L,Sun M,Li L,Yu X,Liu J,Wu J,Yang F,Yu Bdoi
10.1007/s12265-020-09978-3subject
Has Abstractpub_date
2020-03-24 00:00:00eissn
1937-5387issn
1937-5395pii
10.1007/s12265-020-09978-3pub_type
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-019-09903-3
更新日期:2019-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9828-7
更新日期:2018-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-019-09912-2
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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